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Method for evaluating onset risk of coronary heart disease by using value of apolipoprotein E-containing high-density lipoprotein

A high-density lipoprotein, low-density lipoprotein technology, applied in the field of risk assessment of coronary heart disease, can solve problems such as not established

Pending Publication Date: 2018-09-14
BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in past research evidence, the evidence that HDL containing apolipoprotein E can predict the future risk of CHD in individuals has not been established

Method used

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  • Method for evaluating onset risk of coronary heart disease by using value of apolipoprotein E-containing high-density lipoprotein
  • Method for evaluating onset risk of coronary heart disease by using value of apolipoprotein E-containing high-density lipoprotein
  • Method for evaluating onset risk of coronary heart disease by using value of apolipoprotein E-containing high-density lipoprotein

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] To evaluate the association between apolipoprotein E-containing high-density lipoprotein-C and the risk of coronary heart disease (CHD) using the test samples stored in the cardiovascular disease risk factor cohort study in multiple provinces and cities in China. Specifically, at the time of baseline blood collection, the above-mentioned items were measured for 5,417 CHD-free patients. Then, based on the results of the 6.45-year follow-up of the subjects of the cohort study, the incidence of CHD during the investigation period was verified to verify the correlation with the measurement items.

[0093] The determination of high-density lipoprotein-C containing apolipoprotein E uses the following method: In the first step, cholesterol in lipoproteins other than high-density lipoprotein containing apoE is treated with cholesterol esterase, cholesterol oxidase, and peroxidation Hydrogenase elimination; step 2, use cholesterol esterase, cholesterol oxidase, peroxidase to mea...

Embodiment 2

[0098]Using the same cohort study test samples as in Example 1, the correlation between the ratio of apolipoprotein E-containing high-density lipoprotein-C and high-density lipoprotein-C and the risk of CHD was analyzed.

[0099] High-density lipoprotein-C containing apolipoprotein E was measured using the same method as in Example 1, and high-density lipoprotein-C was measured using HDL-EX "Seiken" (manufactured by DENKA SEIKEN Co., Ltd.).

[0100] The ratio of apolipoprotein E-containing HDL-C to HDL-C was divided into the following four groups: less than 8.6%, 8.6-9.2%, 9.3-9.9%, and more than 10.0%, using Cox proportional regression The model compares the hazard ratios of each group with respect to the group containing HDL-C / HDL-C containing 10.0% or more of apolipoprotein E.

[0101] show the result in figure 2 .

[0102] Such as figure 2 As shown, as the ratio of apoE-containing HDL-C / HDL-C becomes smaller, the hazard ratio increases and the risk of CHD increases. ...

Embodiment 3

[0104] Using the same cohort study test samples as in Example 1, the correlation between the ratio of small and dense low-density lipoprotein-C to high-density lipoprotein-C containing apolipoprotein E and the risk of CHD was analyzed.

[0105] High-density lipoprotein-C containing apolipoprotein E was measured using the same method as in Example 1, and small dense low-density lipoprotein-C was measured using Small Dense LDL-EX "Seiken" (DENKA SEIKEN Co., Ltd. system).

[0106] The ratio of small, dense LDL-C to HDL-C containing apoE was divided into the following four groups: less than 4.7%, 4.7-8.6%, 8.7-12.6%, and more than 12.7%, using Cox proportional regression models comparing hazard ratios for each group relative to the small dense LDL-C / HDL-C with apoE less than 4.7% group.

[0107] show the result in image 3 .

[0108] Such as image 3 As shown, as the ratio of small dense LDL-C / HDL-C containing apoE increases, the hazard ratio increases and the risk of CHD incr...

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Abstract

The invention provides a method for evaluating the onset risk of the coronary heart disease by using the value of apolipoprotein E-containing high-density lipoprotein. [Solution] The method for judging the onset risk of the coronary heart disease of an examined individual is provided and comprises measuring at least one of (i) the value of the apolipoprotein E-containing (ApoE) high-density lipoprotein (HDL) in a test sample of the examined individual acquired from the examined individual, (ii) the ratio of the ApoE-containing HDL relative to the HDL, (iii) the ratio of the small dense low-density lipoprotein (Small Dense LDL) relative to the ApoE-containing HDL, (iv) the ratio of the ApoE-containing HDL relative to high-density lipoprotein 2 (HDL2), and (v) the ratio of the ApoE-containing HDL relative to high-density lipoprotein 3 (HDL3), and the reduction of the ApoE-containing HDL in the test sample of the examined individual, the reduction of the ApoE-containing HDL relative to the HDL, the increase of the ratio of the Small Dense LDL relative to the ApoE-containing HDL, the reduction of the ratio of the ApoE-containing HDL relative to the HDL2, and the reduction of the ratioof the ApoE-containing HDL relative to the HDL3 are the evaluating method for judging the risk of the coronary heart disease of the examined individual in the future.

Description

technical field [0001] The invention relates to a method for evaluating the risk of coronary heart disease. Background technique [0002] It is known that high-density lipoprotein (HDL) receives cholesterol from various tissues including the arterial wall, so it is related to the action of removing cholesterol accumulated in cells, and exhibits anti-atherosclerosis effect, so coronary heart disease (Coronary Heart disease) Disease, hereinafter referred to as "CHD") is a protective factor representing the risk of various atherosclerotic cardiovascular diseases, and its blood level becomes a useful indicator for predicting the risk of CHD in the future. [0003] High-density lipoprotein is a complex of proteins called apolipoproteins and lipid components such as phospholipids, cholesterol, and neutral fats. According to the difference in the content ratio of apolipoprotein E (ApoE), one of its components, high-density lipoproteins can be divided into high-density lipoproteins...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/92G01N2333/775G01N2800/324
Inventor 赵冬齐玥刘静赵帆王淼孙佳艺伊藤康樹
Owner BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
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