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Preparation method and applications of high purity cistanche phenyl ethanol glycosides

A technology of phenylethanol glycosides and cistanche, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., and can solve problems such as weakened curative effect, lack of therapeutic drugs, and increased toxicity

Inactive Publication Date: 2018-09-18
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment methods are mainly western medicines, especially hormonal drugs, which generally can only improve the symptoms, but cannot control the progress; and long-term use, the curative effect is weakened and the toxicity is increased. Generally speaking, there is no suitable therapeutic drug in clinical practice.

Method used

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  • Preparation method and applications of high purity cistanche phenyl ethanol glycosides
  • Preparation method and applications of high purity cistanche phenyl ethanol glycosides
  • Preparation method and applications of high purity cistanche phenyl ethanol glycosides

Examples

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Embodiment 1

[0017] The preparation method of the phenylethanol glycoside extract of Cistanche deserticola.

[0018] Step 1. Take 1.0 kg of cistanche coarse powder, decoct and extract once with 10 liters of water, then decoct and extract once with 8 liters of water, combine the extracts, concentrate to 1 liter, add 95% ethanol to make the ethanol concentration reach 70%, 4 Precipitate with alcohol at ℃ for 12 hours, filter, take the supernatant, concentrate under reduced pressure to 0.5 liters, no alcohol smell, add water to 1 liter.

[0019] Step 2. Put the concentrated solution on the Amberlite XAD16HP macroporous adsorption resin column (stem height ratio 1:9), the volume of the resin is 2 liters, after adding the liquid medicine, let it stand for 6 hours, first wash with 4 liters of water, and then use 3 liters of 50 % ethanol elution, the ethanol eluent continues to pass through the glass column of 1 liter of Amberlite FPC22Na macroporous strong acid resin and the glass column of 1 li...

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Abstract

The invention belongs to the field of traditional Chinese medicine extraction, and especially relates to a preparation method of high purity cistanche phenyl ethanol glycosides and an application of high purity cistanche phenyl ethanol glycosides in the preparation of drugs for treating pulmonary fibrosis. The preparation method extracts two high purity cistanche phenyl ethanol glycosides from cistanche. The invention specifically discloses a preparation method and applications of high purity cistanche phenyl ethanol glycosides. Three resin columns are used together; Amberlite XAD16HP macroporous resin is used to remove impurities such as sugar; Amberlite FPC22Na (macroporous strongly acidic styrene resin) and D201 (strong alkali I type anion exchange resin) are used to effectively removepigments and components that are not phenyl ethanol glycosides; three resins are screened from a plurality of resins, the extracted cistanche phenyl ethanol glycosides have a light yellow color; the content of total phenyl ethanol glycosides is more than 95% (weight ratio), the content of echinacoside and verbascoside is more than 85% (weight ratio), and the phenyl ethanol extract has a good effect on preventing pulmonary fibrosis.

Description

technical field [0001] The invention belongs to the field of extraction of traditional Chinese medicines, in particular to a method for preparing high-purity phenylethanol glycosides with two kinds of phenylethanol glycosides as main components from the traditional Chinese medicine Cistanche deserticola and its application in the preparation of anti-pulmonary fibrosis drugs, specifically a high-purity The preparation method and application of pure cistanche phenylethanol glycoside. Background technique [0002] Cistanche deserticola is a perennial herbaceous parasitic plant belonging to the family Cistanche deserticola. Its roots are used for medicine. It was first recorded in "Shen Nong's Materia Medica" and listed as top grade. Warm in nature, sweet in taste, salty, returns to the kidney and large intestine meridian, has the effects of nourishing the liver and kidney, nourishing essence and blood, moistening the intestines and laxative, and is used to treat deficiency of k...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61K31/7028A61K31/7032A61P11/00A61K125/00
CPCA61K31/7028A61K31/7032A61K36/64A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P11/00
Inventor 窦德强刘雪莹王宇萌
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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