Biomarker for early stage discovery and early warning of liver injury, method and application thereof
A biomarker and early detection technology, applied in the field of biomarkers for early detection and early warning of liver damage, can solve the problems of aggravating the double burden on the patient's body and economy, failure to early warning, poor specificity, etc., to improve purity and good storage , improve efficiency and accuracy, and facilitate the effect of later detection
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Embodiment 1
[0056] (1) This project was reviewed and approved by the Ethics Committee of Beijing Chaoyang Hospital Affiliated to Capital Medical University.
[0057] (2) Inclusion criteria for healthy volunteers (20) Age: 18-60 years old; Gender: male or female; Weight: BMI within 19-24 (BMI=weight / height 2 (kg / m 2 )), people who are overweight or underweight should be avoided, the weight of men should not be less than 50kg, and the weight of women should not be less than 45kg; good health, no heart, liver, kidney, digestive tract, nervous system, mental abnormalities and metabolic abnormalities, etc. Medical history, blood pressure, heart rate, electrocardiogram, respiratory status, liver and kidney function, blood routine, urine routine, and chest X-ray are normal or abnormal without clinical significance. Have not taken antibiotics, anti-tumor, anti-tuberculosis, hypoglycemic, hormones, anti-arrhythmic drugs, Chinese herbal medicines and other drugs recently.
[0058] (3) Inclusion c...
Embodiment 2
[0108] Diagnostic Sensitivity and Specificity Evaluation of Phenylalanine
[0109] In this embodiment, the changes of serum amino acid content in healthy volunteers and patients with drug-induced liver injury are provided, as shown in the following table,
[0110] Table 3. Changes of serum amino acid content in healthy volunteers and patients with drug-induced liver injury ( μmol / L)
[0111]
[0112] Compared with healthy group, *P<0.05, **P<0.01.
[0113] The clinical diagnostic performance of phenylalanine, a potential drug-induced liver injury biomarker, was evaluated by ROC curve. The area under the ROC curve (AUC) can reflect the ability of the diagnostic index to distinguish positive and negative diagnoses. The larger the AUC value, the higher the diagnostic accuracy. It is generally believed that when 0.5<AUC<0.7, the diagnostic value is low; when 0.7<AUC<0.9, the diagnostic value is average; when AUC≥0.9, the diagnostic value is high .
[0114] Input the pheny...
Embodiment 3
[0116] This example provides biomarkers for early detection and early warning of liver damage, the biomarkers include: phenylalanine, tyrosine, glutamic acid, ornithine, cysteine, isoleucine , lysine, serine, beta-alanine, taurine and aspartic acid.
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