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Medical composite shaddock peel pectin sponge dressing capable of slowly releasing carried medicines, preparation method of dressing and application of dressing

A technology of pomelo peel pectin and sponge, which is applied in the field of biomedicine, can solve the problems of inability to take into account hemostasis and high cost, and achieve the effects of reducing medical costs, reducing use, and simple production processes

Inactive Publication Date: 2018-09-28
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Purpose of the invention: In view of the disadvantages of hemostasis, antibacterial, high cost, and insufficient self-adhesiveness in the above-mentioned prior art field, the present invention provides a novel medical compound pomelo peel pectin sponge dressing that can be loaded with drugs for sustained release. Need to use cross-linking agent, both hemostatic and antibacterial, good absorption, self-adhesive, and good liquid absorption performance, can be used for clinical wound protection, hemostasis, and promote wound healing

Method used

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  • Medical composite shaddock peel pectin sponge dressing capable of slowly releasing carried medicines, preparation method of dressing and application of dressing
  • Medical composite shaddock peel pectin sponge dressing capable of slowly releasing carried medicines, preparation method of dressing and application of dressing

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Experimental program
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Effect test

Embodiment 1

[0025] Prepare 1% pomelo peel high-ester pectin aqueous solution, 1% 50kDa chitosan (deacetylation degree > 95%) hydrochloric acid solution (1% hydrochloric acid), 1% CMC-Na Aqueous solution, mix and compound the three according to the volume ratio of 1:2:1 (to control the total volume of 100mL), after homogenization, add 10% of the total volume of glycerin to homogenize, adjust the pH to 7 with 0.1mol / L NaOH solution, Continue to homogeneously mix, take 80mL of the sample solution and pour it into the mold, freeze for 12 hours to form, and dry it in a freeze dryer at -53°C to obtain a medical compound pectin sponge dressing that can be loaded with drugs for sustained release.

Embodiment 2

[0027] Prepare respectively the pomelo peel high-ester pectin aqueous solution of mass fraction 1%, the 50kDa chitosan (deacetylation degree>95%) hydrochloric acid solution (mass fraction 1%) of mass fraction 1%, the CMC- Na aqueous solution, the three are mixed and compounded according to the volume ratio of 2:3:2 (total volume is controlled to 100mL), after homogenization, mannitol with a total volume of 8% is added to homogenize, and the pH is adjusted to 0.1mol / L NaOH solution to 7. Continue to homogeneously mix, take 80mL of the sample solution and pour it into the mold, freeze for 12 hours to form, and then dry it in a freeze dryer at -53°C to obtain a medical compound pectin sponge dressing that can be loaded with drugs for sustained release.

Embodiment 3

[0029] The pomelo peel high-ester pectin aqueous solution of 1% mass fraction, the 50kDa chitosan (deacetylation degree > 95%) hydrochloric acid solution (hydrochloric acid of 2% mass fraction) of 1% mass fraction, the CMC- Na aqueous solution, mix the three according to the volume ratio of 3:4:3 (to control the total volume of 100mL), after homogenization, add 10% of the total volume of glycerin to homogenize, and adjust the pH to 7 with 0.1mol / L NaOH solution , continue to homogeneously mix, take 80mL of the sample solution and pour it into the mold, freeze for 12 hours to form, and then dry it in a freeze dryer at -53°C to obtain a medical compound pectin sponge dressing that can be loaded with drugs for sustained release.

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Abstract

The invention discloses a medical composite shaddock peel pectin sponge dressing capable of slowly releasing carried medicines, a preparation method and an application of the dressing. The medical composite shaddock peel pectin sponge dressing is prepared from shaddock peel high-grease pectin solution, chitosan solution and CMC (sodium carboxymethylcellulose)-Na solution according to the volume ratio of (1-3):(2-4):(1-3). The prepared medical composite shaddock peel pectin sponge dressing does not contain cross-linking agents, can stop bleeding and resist bacteria, has good liquid absorption performance and can be used for protection and blooding stop of clinic wounds, a layer-by-layer network structure can be formed, bleeding stopping and resist bacterium resisting medicines such as nano-silver are added, slowly releasing effect of the medicines is improved, medical requirements are further met, and the dressing is simple in preparation process and low in cost.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a novel drug-loaded slow-release medical compound pomelo peel pectin sponge dressing, a preparation method and application. Background technique [0002] Wound dressing is a covering for damaged skin, which acts as a temporary barrier instead of damaged skin during the wound healing process, prevents further infection of the wound, and provides a favorable environment for wound healing. Therefore, an ideal wound dressing should have the following functions: (1) avoid excessive loss of water and body fluids; (2) resist the invasion of bacteria and prevent infection; (3) Moisture-permeable, air-permeable and keeps the wound surface in a moist environment without accumulation of fluid; (4) Has excellent biocompatibility and can promote wound healing. Due to the different forms of wounds and different stages of healing, the requirements for wound dressings are also different. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/20A61L15/42A61L15/44A61L15/46
CPCA61L15/20A61L15/28A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/104A61L2300/254A61L2300/404A61L2300/418A61L2400/04C08L5/06C08L5/08C08L1/286
Inventor 游庆红万苗苗尹秀莲罗楚平张学娟赵瑜辉管明华鹏
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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