Nanocomposite drug-carrying system for reversing mdr effect and its preparation method and application
A nano-composite and drug-carrying technology, applied in the field of biomedical materials, can solve the problems that tumors are difficult to achieve ideal results, the penetration depth of light source is limited, and it is difficult to popularize widely, which is conducive to cell labeling imaging and improving in vivo imaging. effect, effect of improving biocompatibility
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Embodiment 1
[0037] The nanocomposite drug loading system prepared in this example is D-UNT, wherein UN is oleic acid-coated NaYF 4 : Yb / Er powder, the specific steps are as follows:
[0038] (1) Dissolve 1.2 g of sodium hydroxide in 10 mL of deionized water to form a sodium hydroxide solution, then mix the sodium hydroxide solution with 10 mL of ethanol and 20 mL of oleic acid to obtain a mixed solvent, and then add 1.92 mL of 0.25M to the mixed solvent YCl 3 ·6H 2 Aqueous O, 0.432 mL of 0.25 M YbCl 3 ·6H 2 O aqueous solution and 0.048 mL of 0.25M ErCl 3 The aqueous solution was stirred at room temperature for 20 minutes, and the first mixed solution was obtained by stirring evenly; then, under vigorous stirring at room temperature, 4 mL of the aqueous solution containing 4 mmol NaF was added dropwise to the first mixed solution to obtain the second mixed solution, and the stirring was continued for 30 minutes. A colloidal solution was formed, and then the formed colloidal solution w...
Embodiment 2
[0042] The nanocomposite drug loading system prepared in this example is D-UNT, wherein UN is 30%Mn 2+ Doped Oleic Acid Coating NaY(Mn)F 4 : Yb / Er powder, the specific steps are as follows:
[0043](1) Dissolve 1.2g of sodium hydroxide in 10mL of deionized water to form a sodium hydroxide solution, then mix the sodium hydroxide solution with 10mL of ethanol and 20mL of oleic acid to obtain a mixed solvent, and then add 0.72mL of 0.25M MnCl 2 Aqueous solution, 1.2 mL of 0.25M YCl 3 ·6H 2 O in water, 0.432 mL of 0.25M YbCl 3 ·6H 2 O aqueous solution and 0.048 mL of 0.25M ErCl 3 aqueous solution, stirred at room temperature for 20 minutes, and stirred evenly to obtain the first mixed solution; then, under vigorous stirring at room temperature, 4 mL of an aqueous solution containing 4 mmol NaF was added dropwise to the first mixed solution to obtain the second mixed solution, and continued stirring for 30 The colloidal solution was formed in minutes, and then the formed col...
Embodiment 3
[0047] The nanocomposite drug loading system prepared in this example is D-UNT, wherein UN is 50% Mn 2+ Doped oleic acid coated NaY(Mn)F 4 : the powder of Yb / Er, concrete steps are as follows:
[0048] (1) Dissolve 1.2g of sodium hydroxide in 10mL of deionized water to form a sodium hydroxide solution, then mix the sodium hydroxide solution with 10mL of ethanol and 20mL of oleic acid to obtain a mixed solvent, and then add 1.2mL of 0.25M MnCl 2 Aqueous solution, 0.72 mL of 0.25M YCl 3 ·6H 2 O in water, 0.432 mL of 0.25M YbCl 3 ·6H 2 O aqueous solution and 0.048 mL of 0.25M ErCl 3 aqueous solution, stirred at room temperature for 20 minutes, and stirred evenly to obtain the first mixed solution; then, under vigorous stirring at room temperature, 4 mL of an aqueous solution containing 4 mmol NaF was added dropwise to the first mixed solution to obtain the second mixed solution, and continued stirring for 30 The colloidal solution was formed in minutes, and then the formed...
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