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Novel biological patch and preparation method thereof

A biological patch, a new type of technology, applied in medical science, surgery, etc., can solve the problems of strong foreign body sensation, poor flexibility, easy to cause infection, etc., and achieve broad application prospects and good thermoplasticity

Inactive Publication Date: 2018-10-16
段降龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after a long period of clinical use, some disadvantages of the two types of patches have gradually emerged. First, due to poor flexibility, the foreign body sensation after implantation in the human body is strong. Secondly, due to the difference in mechanical compliance between the body and the surrounding tissue, it will gradually cause The fibrosis reaction of the surrounding tissue gradually forms a fibrous envelope. After a long period of use, the product will increase the risk of erosion of adjacent tissues and organs, and the ePTFE product is also easy to cause infection. After infection, a second operation is required to remove it.

Method used

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  • Novel biological patch and preparation method thereof

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Embodiment Construction

[0033] In order to make the object, technical solution and advantages of the present invention clearer, various embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. However, those of ordinary skill in the art can understand that, in each implementation manner of the present invention, many technical details are provided for readers to better understand the present application. However, even without these technical details and various changes and modifications based on the following implementation modes, the technical solutions claimed in this application can also be realized.

[0034] Embodiments of the present invention relate to a preparation method of a novel biological patch, such as figure 1 As shown, the following steps are included in sequence:

[0035] S1, preparation of biological nitrogen-fixing bacteria fermentation culture solution;

[0036] S2, distilling the biological nitrogen-fixing bacteria fer...

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Abstract

The invention relates to the technical field of biological patches, in particular to a novel biological patch and a preparation method thereof. The preparation method comprises the following steps ofpreparing a biological nitrogen-fixation bacterial fermenting culture solution; distilling the biological nitrogen-fixation bacterial fermenting culture solution; extracting PHA (poly-hydroxyalkanoate) by a CHCl3 (chloroform) extracting method in S2; drying the solution after extracting, so as to obtain a PHA powder; analyzing the purity of the PHA by a vapor-phase spectrum method; purifying the object in S4, so as to obtain a collagen-PHA membrane sheet; preparing a polymer solution; soaking the collagen-PHA membrane sheet into the polymer solution, fetching out, relieving pressure and drying, or relieving pressure and drying at high temperature, so as to obtain the biological patch; radiating the obtained biological patch by rays, and sterilizing. The preparation method of the biologicalpatch has the advantages that the preparation method is simple, the yield of the PHA is high, and the purity is high; the medical biological patch prepared from the PHA can be directly absorbed by ahuman body, the rejection reaction of the human body is avoided, and the PHA can be gradually decomposed into CO2 (carbon dioxide) and water in the human body.

Description

technical field [0001] The invention relates to the technical field of biological patch preparation, in particular to a novel biological patch and a preparation method thereof. Background technique [0002] In recent years, with the development of medical technology, more and more patches have been used as tissue and organ repair materials in various surgical operations, such as: hernia surgery, cosmetic plastic surgery, ENT, cranial surgery, etc. At present, patch There are two types of patches: one is obtained through artificial synthesis using non-degradable materials such as polyethylene, polytetrafluoroethylene, or polypropylene. After implanted in the body, this type of patch will form a strong body rejection reaction and is prone to Postoperative complications such as infection. The purpose of using a mesh is to reinforce and bridge damaged or weakened soft tissue. Biological patches are currently used more maturely, with ePTFE as the raw material of puffed patch, a...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/06A61L31/14
CPCA61L31/044A61L31/06A61L31/14A61L31/148C08L67/04
Inventor 段降龙刘思达王朋园张敏党永林侯峰刘登峰魏堃张金平杨国军曹立强
Owner 段降龙
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