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Injectable bone repairing material and preparation method thereof

A technology of bone repair and hydroxyapatite, which is applied in the field of medical materials, can solve problems affecting porosity and compressive strength, and achieve good injection performance

Inactive Publication Date: 2017-04-26
苏州纳贝通环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the injection performance will affect the porosity and compressive strength of the material, so a bone repair material with good biocompatibility and good repair effect is needed

Method used

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  • Injectable bone repairing material and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0017] An injectable bone repair material, prepared from the following ingredients by weight: 30 parts of α-calcium sulfate hemihydrate, 30 parts of hydroxyapatite, 2.5 parts of sodium hyaluronate, 3 parts of octadecanoic acid, carboxymethyl 3 parts of base cellulose, 2.5 parts of calcium sulfate dihydrate, 2 parts of collagen fiber, 3 parts of polyglycolic acid fiber, 2 parts of snail mucus, 2 parts of polyhydroxybutyrate, 8 parts of lactic acid-polyethylene glycol copolymer, 50 parts of ionized water.

[0018] The preparation method of the above-mentioned injectable bone repair material is as follows: (1) Proportionally mix α-calcium sulfate hemihydrate, hydroxyapatite, calcium sulfate dihydrate, collagen fibers, and polyglycolic acid fibers to obtain a solid phase mixture; ( 2) Sodium hyaluronate and carboxymethyl cellulose are dissolved in deionized water to form a solution, and stirred until completely dissolved; (3) Add the solid-phase mixture to the solution in step (2)...

Embodiment 2

[0020] An injectable bone repair material, prepared from the following components by weight: 50 parts of α-calcium sulfate hemihydrate, 20 parts of hydroxyapatite, 15 parts of sodium hyaluronate, 1 part of octadecanoic acid, carboxymethyl 1 part of base cellulose, 4 parts of calcium sulfate dihydrate, 3 parts of collagen fiber, 2 parts of polyglycolic acid fiber, 3 parts of snail mucus, 8 parts of polyhydroxybutyrate, 2 parts of lactic acid-polyethylene glycol copolymer, 80 parts of ionized water.

[0021] The preparation method of the above-mentioned injectable bone repair material is as follows: (1) Proportionally mix α-calcium sulfate hemihydrate, hydroxyapatite, calcium sulfate dihydrate, collagen fibers, and polyglycolic acid fibers to obtain a solid phase mixture; ( 2) Sodium hyaluronate and carboxymethyl cellulose are dissolved in deionized water to form a solution, and stirred until completely dissolved; (3) Add the solid-phase mixture to the solution in step (2) and s...

Embodiment 3

[0023] An injectable bone repair material, prepared from the following components by weight: 35 parts of α-calcium sulfate hemihydrate, 28 parts of hydroxyapatite, 5 parts of sodium hyaluronate, 2.5 parts of octadecanoic acid, carboxymethyl 1.5 parts of base cellulose, 3 parts of calcium sulfate dihydrate, 2.2 parts of collagen fiber, 2.8 parts of polyglycolic acid fiber, 2.2 parts of snail mucus, 4 parts of polyhydroxybutyrate, 6 parts of lactic acid-polyethylene glycol copolymer, 60 parts of ionized water.

[0024] The preparation method of the above-mentioned injectable bone repair material is as follows: (1) Proportionally mix α-calcium sulfate hemihydrate, hydroxyapatite, calcium sulfate dihydrate, collagen fibers, and polyglycolic acid fibers to obtain a solid phase mixture; ( 2) Sodium hyaluronate and carboxymethyl cellulose are dissolved in deionized water to form a solution, and stirred until completely dissolved; (3) Add the solid-phase mixture to the solution in ste...

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Abstract

The invention provides an injectable bone repairing material and a preparation method of the injectable bone repairing material. The preparation method comprises the following steps: (1) proportionally preparing and uniformly mixing alpha-calcium sulfate hemihydrate, hydroxyapatite, calcium sulphate dihydrate, collagen fibers and polyglycolic acid fibers to obtain a solid-phase mixture; (2) dissolving hyaluronic acid and carboxymethyl cellulose in deionized water to be prepared into a solution, and stirring until hyaluronic acid and carboxymethyl cellulose are completely dissolved; (3) adding the solid-phase mixture into the solution in the step (2) and uniformly stirring, wherein the stirring time is 5 to 12min, and the stirring speed is 120 to 200r / min; (4) successively adding octadecanoic acid, snail mucus, polyhydroxybutyrate and a lactic acid-polyethylene glycol copolymer, continuously stirring for 5 to 10min, and keeping the revolving speed at 60 to 80r / min, thus obtaining the injectable bone repair material. The injectable bone repair material disclosed by the invention is very high in porosity, and further higher in compressive strength.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an injectable bone repair material and a preparation method thereof. Background technique [0002] Bone tissue injury and defect are common clinical problems in orthopedics. Bone grafting for bone defect repair has become the second only tissue transplant after blood transfusion in the United States. There are as many as 3 million patients in China who need bone transplantation due to bone defects caused by traffic accidents and work-related injuries every year. In addition to autologous bone and allogeneic bone, bone graft materials currently used clinically also include bioceramics, high molecular polymers, tissue engineered bone and artificial bone. Among them, the artificial bone prepared from α-calcium sulfate hemihydrate has been recognized by many surgical workers for its degradability, excellent biocompatibility, and osteoconductivity. Its advantages are: (1) wide sourc...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/02A61L27/12A61L27/20A61L27/24A61L27/18A61L27/36
CPCA61L27/56A61L27/025A61L27/12A61L27/18A61L27/20A61L27/24A61L27/3637A61L2400/06A61L2430/02C08L89/00C08L5/08C08L1/286C08L67/04
Inventor 潘明华
Owner 苏州纳贝通环境科技有限公司
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