Non-functional pituitary adenoma detection device and application

A pituitary adenoma and detection device technology, applied in the field of molecular biology, can solve the problems of unclear pathogenesis of pituitary adenoma, difficulty in early diagnosis, etc., and achieve the effect of simple and reliable diagnosis method and high clinical value
CN108707548BActive Publication Date: 2022-05-03BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Publication Date
2022-05-03

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Abstract

The invention provides a non-functional pituitary adenoma detection device and its application. The device of the present invention performs Massarray SNP typing detection on the single nucleotide polymorphism site rs2910200 of the sample to be tested. This site has a significant correlation with the pathogenesis of non-functioning pituitary tumors. The different genetic models of this locus can provide a certain basis for the diagnosis of non-functioning pituitary tumors and have high clinical value. The invention can provide a simple and reliable diagnostic method for the early diagnosis of patients with non-functional pituitary tumors.
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Description

technical field

[0001] The invention belongs to the field of molecular biology, and in particular relates to a non-functional pituitary adenoma detection device and its application. Background technique

[0002] Pituitary tumor is one of the common neuroendocrine tumors that can lead to the imbalance of pituitary hormone secretion. Its incidence ranks third in the incidence of intracranial tumors after glioma and meningioma. Epidemiological studies have shown that the incidence rate of pituitary tumors in the general population is as high as 16.7%, and they can occur at any age, most of whom are 30-50 years old. Nonfunctioning adenomas account for about 15%-54% of pituitary tumors. Because non-functioning pituitary adenomas cannot show hormone-related syndromes and lack obvious relevant clinical symptoms, early diagnosis in clinical practice is quite difficult.

[0003] Patients with pituitary tumors may have clinical manifestations ranging in severity at different periods...

Claims

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