Application of patchouli alcohol in preparation of endothelium-independent vasodilator
A technology of potiole alcohol and dilator, which is applied in the direction of cardiovascular system diseases, active ingredients of hydroxyl compounds, nervous system diseases, etc., to achieve the effect of excellent curative effect and high sensitivity
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Embodiment 1
[0018] Example 1: Bukitschyl Alcohol Concentration-Dependent Diastolic Effects of Potassium Chloride Precontracted Endothelialized Vascular Rings
[0019] 1 Materials and Instruments
[0020] 1.1 Drugs and preparation
[0021] Patchouli medicinal material was collected from the patchouli planting base in Yangchun County, Guangdong Province in November 2012. It was identified as Pogostemon cablin (Blanco ) Benth.) whole plant.
[0022] Take 40Kg of the dried above-ground part of Patchouli medicinal material, use a large-scale improved steam distillation device to extract, dry and remove water through anhydrous sodium sulfate, and finally obtain 215g of Patchouli volatile oil. Use silica gel column chromatography (100-200 mesh, 5Kg, 20×150cm) to chromatographically separate the volatile oil, use petroleum ether-acetone (100:0-0:100) as the mobile phase for gradient elution, and the eluent passes through thin layer For chromatographic detection, fractions with similar composit...
Embodiment 2
[0041] EXAMPLE 2: Buocchiol concentration-dependent relaxation of phenylephrine-precontracted endothelialized vascular rings
[0042] 1 Materials and Instruments
[0043] 1.1 Drugs and preparation
[0044] Patchouli medicinal material was collected from the patchouli planting base in Yangchun County, Guangdong Province in November 2012. It was identified as Pogostemon cablin (Blanco ) Benth.) whole plant.
[0045]Take 40Kg of the dried above-ground part of Patchouli medicinal material, use a large-scale improved steam distillation device to extract, dry and remove water through anhydrous sodium sulfate, and finally obtain 215g of Patchouli volatile oil. Use silica gel column chromatography (100-200 mesh, 5Kg, 20×150cm) to chromatographically separate the volatile oil, use petroleum ether-acetone (100:0-0:100) as the mobile phase for gradient elution, and the eluent passes through thin layer For chromatographic detection, fractions with similar composition were combined, and...
experiment example 1
[0066] Experimental Example 1 Pocket Alcohol Treatment of Hypertension
[0067] 1 Materials and Instruments
[0068] 1.1 Drugs and preparation
[0069] Patchouli medicinal material was collected from the patchouli planting base in Yangchun County, Guangdong Province in November 2012. It was identified as Pogostemon cablin (Blanco ) Benth.) whole plant.
[0070] Take 40Kg of the dried above-ground part of Patchouli medicinal material, use a large-scale improved steam distillation device to extract, dry and remove water through anhydrous sodium sulfate, and finally obtain 215g of Patchouli volatile oil. Use silica gel column chromatography (100-200 mesh, 5Kg, 20×150cm) to chromatographically separate the volatile oil, use petroleum ether-acetone (100:0-0:100) as the mobile phase for gradient elution, and the eluent passes through thin layer For chromatographic detection, fractions with similar composition were combined, and the solvent was recovered to obtain 31 eluted fracti...
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