Preparation method for 3-methoxy-cinnamic acid
A technology of methoxycinnamic acid and methoxybenzaldehyde, applied in the field of medicine, can solve the problems of unstable yield, low yield of 3-methoxycinnamic acid, complex synthesis process, etc., and achieve high procurement cost Effect
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Embodiment 1
[0007] Embodiment 1: the preparation of 3-methoxycinnamic acid:
[0008] Add 1361 mg of 3-methoxybenzaldehyde in the reactor, add 20 ml of xylene, stir, add 3 ml of malonic acid at room temperature, then stir at room temperature for 30 minutes, then add 1000 mg of pyridine, and then continue to The reaction was stirred at 80°C for 2 hours. After the completion of the reaction, the compound 3-methoxycinnamic acid was obtained through post-treatment and purification processes with a yield of 93.9%.
Embodiment 2
[0009] Embodiment 2: the preparation of 3-methoxycinnamic acid:
[0010] Add 1361 mg of 3-methoxybenzaldehyde in the reactor, add 20 ml of xylene, stir, add 3 ml of malonic acid at room temperature, then stir at room temperature for 30 minutes, then add 1000 mg of pyridine, and then continue to The reaction was stirred at 80°C for 2 hours. After the reaction was completed, the compound 3-methoxycinnamic acid was obtained through post-treatment and purification processes with a yield of 91.1%.
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