Iterative image reconstruction in image-guided radiation therapy

Abstract

Reconstruction of projection images of a CBCT scan is performed by generating simulated projection data, comparing the simulated projection data to the projection images of the CBCT scan, determininga residual volume based on the comparison, and using the residual volume to determine an accurate reconstructed volume. The reconstructed volume can be used to segment a tumor (and potentially one ormore organs) and align the tumor to a planning volume (e.g., from a CT scan) to identify changes, such as shape of the tumor and proximity of the tumor to an organ. These changes can be used to updatea radiation therapy procedure, such as by altering a radiation treatment plan and fine-tuning a patient position.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to and is a PCT application of U.S. Provisional Application No. 62 / 242,967, entitled "Iterative Image Reconstruction InImage-Guided Radiation Therapy," filed October 16, 2015, the entirety of which The contents are hereby incorporated by reference for all purposes. Background technique [0003] In radiation therapy, a treatment plan is first determined. The patient is typically imaged using computed tomography (CT), and the resulting data is used to determine a treatment plan for one or more treatment sessions, which may be performed over multiple days. It is important to have the patient in a specific position during treatment that matches that for the planned CT. However, a CT machine is different from a radiation therapy machine, so it is difficult to obtain an accurate matching body position. To address this problem, some techniques perform image-guided radiation therapy (IGRT), i...

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Problems solved by technology

Also, the use of imaging to guide radiation therapy is limited as patient positioning remains the only major use case due to such limitations

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