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Traditional Chinese medicine composition containing traditional Chinese medicine extract and application of traditional Chinese medicine composition containing traditional Chinese medicine extract

A technology of extracts and compositions, applied in the field of Chinese medicine compositions containing Chinese medicine extracts, can solve the problems of high cost and inability to be widely used, and achieve good inhibitory effect and good auxiliary therapeutic effect

Inactive Publication Date: 2018-12-21
北京维特百草健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is that the medicines used for gastric mucosal injury in the prior art have high cost and cannot be widely used. Therefore, a Chinese medicine composition containing Chinese medicine extract and its application are provided, which enhance the efficacy and health care function, Increased the breadth of its application range

Method used

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  • Traditional Chinese medicine composition containing traditional Chinese medicine extract and application of traditional Chinese medicine composition containing traditional Chinese medicine extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Preparation of a Chinese medicine composition containing Chinese medicine extracts with the function of protecting the gastric mucosa

[0036] The astragalus extract, propolis extract, Hericium erinaceus extract, sesame oil, microcrystalline cellulose, and beeswax used in this example can all be purchased through commercial channels.

[0037]The Chinese medicine composition containing the Chinese medicine extract that this embodiment prepares is as follows:

[0038]

[0039]

[0040] The preparation method of the Chinese medicine composition containing the Chinese medicine extract with the function of protecting gastric mucosa in this embodiment is as follows:

[0041] 1. Prepare materials

[0042] Prepare qualified raw materials and auxiliary materials according to the formula requirements, remove the outer packaging and transfer them to the clean production area.

[0043] 2. Ingredients and pretreatment

[0044] The propolis extract was frozen for ...

Embodiment 2

[0053] Example 2: Animal Safety Evaluation of the Chinese Medicine Composition Containing Chinese Medicine Extract Prepared in Example 1

[0054] 1. Materials and methods

[0055] 1.1 Samples: Chinese medicine compositions A, B, C, D and E containing Chinese medicine extracts prepared in Example 1 above.

[0056] 1.2 Experimental animals

[0057] SPF-grade Kunming mice, SD rats and feed were provided by Changsha Tianqin Biotechnology Co., Ltd., and the experimental animal production license number was SCXK (Xiang) 2014-0011. The experimental environment is a barrier environment. During the experiment, the temperature of the experimental environment is 23-26° C. and the humidity is 52-56%. Experimental animal use license number SYXK (Xiang) 2015-0012.

[0058] 1.3 Experimental methods and results

[0059] (1) Oral acute toxicity test:

[0060] The Chinese medicine composition B containing the Chinese medicine extract prepared in Example 1 has the following effects on the o...

Embodiment 1

[0066] The results of three genotoxicity tests of the Chinese medicine composition B containing the Chinese medicine extract prepared in Example 1 are as follows:

[0067] ①Ames test: Four strains of Salmonella typhimurium with histidine deficiency TA97a, TA98, TA100, and TA102 that have been identified and met the requirements were used for the test. , At the same time set spontaneous back-change control, solvent control and positive mutagen control, culture at 37°C for 48 hours, count the number of colonies per plate. It was found that the number of reverted colonies in each dose group of the sample was not more than 2 times the number of spontaneous reverted colonies for the four test strains TA97a, TA98, TA100, and TA102, and there was no dose-response relation. Show that the Ames test of this product sample is negative. The specific results are shown in Table 3 and Table 4.

[0068] Table 3 Sample Ames test results (first time)

[0069]

[0070] Positive control:...

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Abstract

The invention discloses a traditional Chinese medicine composition containing a traditional Chinese medicine extract and application. The traditional Chinese medicine composition containing a traditional Chinese medicine extract is mainly prepared from the following raw materials in parts by weight: 50-120 parts of a radix astragali extract, 30-80 parts of a propolis extract and 30-80 parts of a hericium erinaceus extract. Animal experiment and human body function experiment prove that the traditional Chinese medicine composition containing a traditional Chinese medicine extract provided by the invention has the function of protecting gastric mucosa and the effect of resisting infection by helicobacter pylori.

Description

technical field [0001] The invention relates to the technical field of medical care, and more specifically relates to a Chinese medicine composition containing Chinese medicine extracts and an application thereof. Background technique [0002] Gastric mucosal injury is a common clinical disease. Modern medicine believes that this disease is the result of an imbalance between the aggressive factors that damage the gastric mucosa and the mucosal self-defense factors. When the damaging factors are enhanced and / or the protective factors are weakened, Injury or even ulceration may occur in the gastric mucosa. Damage factors include gastric acid, pepsin, refluxed upper small intestinal fluid, Helicobacter pylori (HP), etc. Protective factors include gastric mucosal barrier and gastric mucus barrier. [0003] Traditional Chinese medicine believes that gastric mucosal diseases belong to the category of "spleen and stomach diseases", and are generally believed to be most closely rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P1/04A61P31/04A61K35/644
CPCA61K35/644A61K36/07A61K36/481A61P1/04A61P31/04A61K2300/00
Inventor 李志磊邹忠全王全杨光
Owner 北京维特百草健康科技有限公司
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