Microelectrode amplifier zero return circuit and method for realizing fast zero return

Abstract

The invention discloses a microelectrode amplifier zero returning circuit and a method for realizing fast zero returning thereof. The microelectrode amplifier zero returning circuit comprises a signalfollower, an adder, a digital-to-analog converter, a processor and an analog-to-digital converter. The signal follower is used for for performing impedance transformation on an input microelectrode signal. The adder adds an output signal of the signal follower to an output signal of the digital-to-analog converter, and outputs a zero-returning microelectrode potential signal. The digital-to-analog converter converts a digital zero-returning compensation value output by the processor into an analog quantity. The processor calculates the zero-returning compensation value according to the outputof the adder. The analog-to-digital converter converts an analog signal output by the adder into a digital signal to the processor. The program is avoided to enter an endless loop in the zero returning process, the direct current component of a level signal is eliminated by the adder, fast zero returning is realized, and the accuracy of the test result is improved.

Description

technical field [0001] The invention belongs to the technical field of instruments and meters, and in particular relates to a microelectrode amplifier zero return circuit and a method for realizing fast zero return. Background technique [0002] With the development of life science and technology, people have increasingly extensive research on various cell tissues such as brain cells and cardiomyocytes, which requires microelectrodes that can be inserted into biological cells to sample intracellular signals. [0003] Microelectrodes are electrode probes with very thin tips. It can be used for both intracellular and extracellular measurements. For intracellular measurements, a glass microelectrode is usually used, which is perfused with a saline solution (such as saturated KCl or NaCl) and forms a salt bridge with the metal contact point of the electrode holder, thus forming part of the circuit. The tip of the glass microelectrode is drawn very thin (generally no more than ...

AI Technical Summary

Problems solved by technology

[0005] Due to its functional complexity, the system structure of such products is complicated, the operation is complicated, and the performance is unstable. The production process is various and the requirements for electronic devices are high and the price is high. Introduced measurement error

[0006] Due to the existence of external interference, the process of solving the dichotomy will enter an infinite loop branch, causing the program to freeze

The extreme resistance test stimulates the high and low waves to be asymmetrical, and the unzeroed extreme resistance excitation test wave will affect the accuracy of the test results

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