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A kind of medicine for treating intractable nephrogenic edema and preparation method thereof

A production method and intractable technology, applied in the directions of pharmaceutical formulations, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of large injury, many side effects, thromboembolism, etc., and achieve no drug resistance and good curative effect. Effect

Active Publication Date: 2021-08-24
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned therapies can achieve certain curative effect in a short period of time, they have many side effects and high costs, so they should be used with caution in clinical practice.
On the one hand, hemodialysis and blood purification treatment are more harmful to patients, and on the other hand, they bring financial and mental burden to patients because of the high cost.
[0004] In addition, in the clinical treatment of edema, diuretics are still mainly used for treatment, but they are often unsatisfactory. Many edemas are intractable, and it is difficult to subside even with the use of large doses of diuretics. Even severe edema or excessive use Diuretics lead to thromboembolism and even renal failure, causing great distress to clinicians

Method used

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  • A kind of medicine for treating intractable nephrogenic edema and preparation method thereof
  • A kind of medicine for treating intractable nephrogenic edema and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Recipe: Guizhi 240g, Paeoniae Alba 300g, Ginger 120g, Cumin 80g, Ligusticum Chuanxiong 100g, Asarum 60g, Earthworm 100g, Dried Ginger 150g and Chinese Yam 150g.

[0067] Process: Take the above-mentioned medicine, dry it, and grind it into fine particles to obtain a powder.

[0068] Usage and dosage: Prepare the medicinal powder made by the above method into a paste with warm water at about 45-55°C, apply the prepared medicinals on the gauze, apply the gauze to the edematous part of the patient, and bake it with an infrared oven for 20-30 minutes Finally, wait for 5-10 minutes until the residual temperature dissipates and remove the gauze. 1-2 times a day. The course of treatment is 7-10 days.

Embodiment 2

[0070] Recipe: Guizhi 260g, Paeoniae Alba 310g, Ginger 130g, Cumin 90g, Ligusticum Chuanxiong 110g, Asarum 70g, Earthworm 110g, Dried Ginger 160g and Chinese Yam 160g.

[0071] Process: including the following steps:

[0072] (1) Take the above-mentioned medicine, use 6 times the amount of 70% ethanol to reflux and extract twice, each time for 1 hour, the extract is filtered, and the filtrate reclaims ethanol and concentrates it into an extract with a relative density of 1.10-1.12 when it is concentrated at 50-60 ° C. Get A product;

[0073] (2) Take 4% sorbitol and 4% glycerin, add to product A, heat to 85-90°C to dissolve, and get product B;

[0074] (3) Take another 6% stearic acid, 5% stearin, 2% yellow vaseline, 6% polysorbate 80, 1% lanolin and 1% sucrose stearate to heat Melt at 85-90°C to obtain product C;

[0075] (4) Products B and C were mixed and emulsified for 25 minutes, kept at 60-70°C for 55 minutes, added 0.4% benzoic acid and 0.15% ethylparaben, mixed even...

Embodiment 3

[0078] Recipe: Guizhi 220g, Paeoniae Alba 290g, Ginger 110g, Cumin 70g, Chuanxiong 90g, Asarum 50g, Dilong 90g, Dried Ginger 140g and Chinese Yam 140g.

[0079] Process: including the following steps:

[0080] (1) Take the above-mentioned medicine, use 6 times the amount of 70% ethanol to reflux and extract twice, each time for 1 hour, the extract is filtered, and the filtrate reclaims ethanol and concentrates it into an extract with a relative density of 1.10-1.12 when it is concentrated at 50-60 ° C. Get A product;

[0081] (2) get A product weight 35% rubber, 35% rosin, 5% vaseline and 15% lanolin heating and melting, get B product;

[0082] (3) Product B is added to Product A, mixed with 6% glycerin and 40% zinc oxide by weight of Product B and stirred for 23 minutes to obtain the drug material, and the mounting material, medical polyester film and drug material are respectively packed into the patch In the coating equipment, after rolling, forming, cutting, sub-packagin...

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Abstract

The invention discloses a medicine for treating obstinate renal edema and a preparation method thereof. The medicine is mainly prepared from cassia twig, white peony root, ginger, fennel, chuanxiong, asarum, earthworm, dried ginger and yam . Each component has a very good synergistic effect. In the prescription, Guizhi warms the meridians, helps Yang transform Qi, white peony root nourishes blood and restrains Yin, ginger warms meridian and dispels cold, fennel regulates Qi and dispels cold, Chuanxiong promotes blood and Qi, Asarum dispels wind powder Cold, earthworm dredges collaterals and removes blood stasis, dried ginger warms meridians, yam nourishes spleen and kidney. The combination of all medicines has the effects of warming the meridians and dredging collaterals, diuresis and detumescence, and can be used to treat intractable renal edema, with good curative effect, no drug resistance and no side effects, thus achieving the purpose of the invention.

Description

technical field [0001] The invention relates to a medicine for treating intractable renal edema and a preparation method thereof, belonging to the technical field of medicines. [0002] technical background [0003] Renal edema is edema caused by various primary or secondary factors leading to glomerular damage, decreased filtration function, and excessive fluid accumulation in the tissue intermittently. There is no unified definition of intractable edema. It usually refers to edema that has not improved significantly after diuretic or combined diuretic treatment. It often occurs in various clinical kidney diseases, heart failure, late liver disease, lymphatic flow obstruction, etc. Condition. Renal refractory edema, due to poor response to conventional detumescence treatment (such as low-salt diet, diuretics), tends to be progressive and aggravated. It is one of the more difficult problems in the treatment of kidney diseases, and it is common in primary or secondary Refrac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P13/12A61P7/10A61K35/62
CPCA61K35/62A61K36/235A61K36/236A61K36/268A61K36/54A61K36/65A61K36/71A61K36/8945A61K36/9068A61K2236/333A61K2236/39A61P7/10A61P13/12A61K2300/00
Inventor 詹继红
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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