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Drug for treating intractable renal edema and production method thereof

A production method and stubborn technology, applied in the field of pharmaceuticals, can solve problems such as many side effects, thromboembolism, and high cost

Active Publication Date: 2019-01-01
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned therapies can achieve certain curative effect in a short period of time, they have many side effects and high costs, so they should be used with caution in clinical practice.
On the one hand, hemodialysis and blood purification treatment are more harmful to patients, and on the other hand, they bring financial and mental burden to patients because of the high cost.
[0003] In addition, in the clinical treatment of edema, diuretics are still mainly used for treatment, but they are often unsatisfactory. Many edemas are intractable, and it is difficult to subside even with the use of large doses of diuretics. Even severe edema or excessive use Diuretics lead to thromboembolism and even renal failure, causing great distress to clinicians

Method used

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  • Drug for treating intractable renal edema and production method thereof
  • Drug for treating intractable renal edema and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Recipe: Guizhi 240g, Paeoniae Alba 300g, Ginger 120g, Cumin 80g, Ligusticum Chuanxiong 100g, Asarum 60g, Earthworm 100g, Dried Ginger 150g and Chinese Yam 150g.

[0066] Process: Take the above-mentioned medicine, dry it, and grind it into fine particles to obtain a powder.

[0067] Usage and dosage: Prepare the medicinal powder made by the above method into a paste with warm water at about 45-55°C, apply the prepared medicinals on the gauze, apply the gauze to the edematous part of the patient, and bake it with an infrared oven for 20-30 minutes Finally, wait for 5-10 minutes until the residual temperature dissipates and remove the gauze. 1-2 times a day. The course of treatment is 7-10 days.

Embodiment 2

[0069] Recipe: Guizhi 260g, Paeoniae Alba 310g, Ginger 130g, Cumin 90g, Ligusticum Chuanxiong 110g, Asarum 70g, Earthworm 110g, Dried Ginger 160g and Chinese Yam 160g.

[0070] Process: including the following steps:

[0071] (1) Take the above-mentioned medicine, use 6 times the amount of 70% ethanol to reflux and extract twice, each time for 1 hour, the extract is filtered, and the filtrate reclaims ethanol and concentrates it into an extract with a relative density of 1.10-1.12 when it is concentrated at 50-60 ° C. Get A product;

[0072] (2) Take 4% sorbitol and 4% glycerin, add to product A, heat to 85-90°C to dissolve, and get product B;

[0073] (3) Take another 6% stearic acid, 5% stearin, 2% yellow vaseline, 6% polysorbate 80, 1% lanolin and 1% sucrose stearate to heat Melt at 85-90°C to obtain product C;

[0074] (4) Products B and C were mixed and emulsified for 25 minutes, kept at 60-70°C for 55 minutes, added 0.4% benzoic acid and 0.15% ethylparaben, mixed even...

Embodiment 3

[0077] Recipe: Guizhi 220g, Paeoniae Alba 290g, Ginger 110g, Cumin 70g, Chuanxiong 90g, Asarum 50g, Dilong 90g, Dried Ginger 140g and Chinese Yam 140g.

[0078] Process: including the following steps:

[0079] (1) Take the above-mentioned medicine, use 6 times the amount of 70% ethanol to reflux and extract twice, each time for 1 hour, the extract is filtered, and the filtrate reclaims ethanol and concentrates it into an extract with a relative density of 1.10-1.12 when it is concentrated at 50-60 ° C. Get A product;

[0080] (2) get A product weight 35% rubber, 35% rosin, 5% vaseline and 15% lanolin heating and melting, get B product;

[0081] (3) Product B is added to Product A, mixed with 6% glycerin and 40% zinc oxide by weight of Product B and stirred for 23 minutes to obtain the drug material, and the mounting material, medical polyester film and drug material are respectively packed into the patch In the coating equipment, after rolling, forming, cutting, sub-packagin...

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Abstract

The invention discloses a drug for treating intractable renal edema and a production method thereof. The drug is mainly prepared from ramulus cinnamomi, radix paeoniae alba, rhizoma zingiberis recens,fructus foeniculi, rhizoma Chuanxiong, herba asari, earthworm, rhizoma zingiberis and rhizoma dioscoreae. All components have good synergistic effect, the ramulus cinnamomi in the formula can warm the meridians and support Yang, the radix paeoniae alba can nourish the blood and retain Yin with astringent, the rhizoma zingiberis recens can warm the meridians and dispel the cold, the fructus foeniculi can regulate the vital energy and dispel the cold, the rhizoma Chuangxiong can accelerate the blood circulation, the herba asari can expel the wind and dispel the cold, the earthworm can dredge collaterals and remove the blood stasis, the rhizoma zingiberis can warm the meridians, and the rhizoma dioscoreae can tonify the spleen and tonify the kidney. All Chinese herbs are cooperated to play an efficacy for warming the meridians, using diuretic of hydragogue to alleviate water retention and eliminating the swelling, and the drug can be used for treat the intractable renal edema, and is good in curative effect and free from drug resistance and side effect, thereby achieving the aim of the invention.

Description

technical field [0001] The invention relates to a medicine for treating intractable renal edema and a preparation method thereof, belonging to the technical field of medicines. technical background [0002] Renal edema is edema caused by various primary or secondary factors leading to glomerular damage, decreased filtration function, and excessive fluid accumulation in the tissue intermittently. There is no unified definition of intractable edema. It usually refers to edema that has not improved significantly after diuretic or combined diuretic treatment. It often occurs in various clinical kidney diseases, heart failure, late liver disease, lymphatic flow obstruction, etc. Condition. Renal refractory edema, due to poor response to conventional detumescence treatment (such as low-salt diet, diuretics), tends to be progressive and aggravated. It is one of the more difficult problems in the treatment of kidney diseases, and it is common in primary or secondary Refractory nep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P13/12A61P7/10A61K35/62
CPCA61K35/62A61K36/235A61K36/236A61K36/268A61K36/54A61K36/65A61K36/71A61K36/8945A61K36/9068A61K2236/333A61K2236/39A61P7/10A61P13/12A61K2300/00
Inventor 詹继红
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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