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Drug composition for preventing or treating Alzheimer's disease and application thereof

A composition and vitamin technology, applied in the directions of drug combination, application, active ingredients of heterocyclic compounds, etc., can solve problems such as unclear prospects, and achieve the effects of promoting ATP production, slowing neuroinflammation, and slowing memory damage

Inactive Publication Date: 2019-01-04
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, a variety of AD drugs have failed in Phase III clinical trials (Nature Reviews Drug Discovery, 2017, 16:819). Although there are still drugs under research, the prospects are still unclear

Method used

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  • Drug composition for preventing or treating Alzheimer's disease and application thereof
  • Drug composition for preventing or treating Alzheimer's disease and application thereof
  • Drug composition for preventing or treating Alzheimer's disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: the preparation of formula

[0042] The composition and ingredients of the formula of this embodiment are shown in Table 1, and there are 11 ingredients in total, with a total weight of 32.5796 grams. See Table 1 for the purchasing source and purity level of each component. Mix the ingredients in Table 1 at room temperature (25°C), knead them into balls (about 0.2 cm in diameter), and dry them at room temperature.

[0043] Table 1 Formula ingredients, content percentage, source and purity grade for preventing, slowing down or treating Alzheimer's disease

[0044]

[0045]

[0046] When feeding the mice, it was weighed and mixed with the daily feed of the mice at a ratio of 32.5796:67.4204.

Embodiment 2

[0047] The preparation of embodiment 2 formula

[0048] 26.6 parts of linoleic acid, 0.95 parts of Moringa oleic acid, 0.95 parts of arachidonic acid, 0.095 parts of β-sitosterol, 0.0142 parts of vitamin B1, 0.0133 parts of vitamin C, 0.0142 parts of vitamin E, 0.019 parts of vitamin B5, and vitamin B20. 0114 parts, vitamin B3 0.0034 parts, aspartic acid 2.28 parts.

[0049] The preparation method of this composition is with embodiment 1.

Embodiment 3

[0050] The preparation of embodiment 3 formula

[0051] 29.4 parts of linoleic acid, 1.05 parts of Moringa oleic acid, 1.05 parts of arachidonic acid, 0.105 parts of β-sitosterol, 0.0158 parts of vitamin B1, 0.0147 parts of vitamin C, 0.0158 parts of vitamin E, 0.021 parts of vitamin B5, vitamin B20. 0126 parts, vitamin B3 0.0038 parts, aspartic acid 2.52 parts.

[0052] The preparation method of this composition is with embodiment 1.

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Abstract

The invention discloses a composition. The composition is prepared from linoleic acid, moringa seed oleic acid, arachidonic acid, b-sitosterol, vitamin B1, vitamin C, vitamin E, vitamin B5, vitamin B2, vitamin B3 and aspartic acid. The invention further discloses application of the composition in preparing a drug or food for preventing and treating the Alzheimer's disease. The composition has thefunctions of increasing the levels of dopamine and serotonin, maintaining the mobility of cell membranes, promoting glucose metabolism, promoting generation of ATP, resisting free radicals and oxidative stress, inhibiting inflammation-promoting genes, adding the functions of an acetylcholinesterase inhibitor and adjusting modification of histone and modification of DNA. The overall result shows that the composition alleviates memory impairment, slows down the AD progress, promotes updating of stem cells, alleviates the neuroinflammation and has the functions of alleviating and treating the Alzheimer's disease. Thirty days after an Alzheimer's disease model mouse eats the composition food, the learning capacity and spatial orientation capacity are obviously improved.

Description

technical field [0001] The invention belongs to the fields of medicine and food, and in particular relates to a pharmaceutical composition for preventing or treating Alzheimer's disease and its application. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease that seriously endangers human health. At the molecular level, it mainly manifests as Aβ precipitation outside the nerve cells and the formation of phosphorylated Tau protein in the cells. neurofibrillary tangles (NFT). These two factors lead to the death of neurons through a complex process, which leads to the degenerative loss of memory and cognitive function of patients. One out of every two people over the age of 80 will suffer from Alzheimer's disease. With the advent of China's aging society, the number of patients with Alzheimer's disease will increase sharply. Prevention, mitigation or treatment of the disease measures are urgent. [0003] Currently, the drugs approved by the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/201A61K31/202A61K31/575A61K31/51A61K31/355A61K31/375A61K31/525A61K31/197A61K31/455A61K31/198A61K36/185A61P25/28A23L33/12A23L33/15A23L33/175
CPCA23L33/12A23L33/15A23L33/175A23V2002/00A61K31/197A61K31/198A61K31/201A61K31/202A61K31/355A61K31/375A61K31/455A61K31/51A61K31/525A61K31/575A61K36/185A61P25/28A61K2300/00A23V2200/322A23V2250/1862A23V2250/186A23V2250/7042A23V2250/708A23V2250/705A23V2250/712A23V2250/7044A23V2250/7046A23V2250/061A23V2250/21372
Inventor 刘宏德
Owner SOUTHEAST UNIV
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