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A 3D printed microneedle patch for intelligent blood sugar regulation and its preparation method

A 3D printing and intelligent adjustment technology, which is applied in the field of biomedicine, can solve the problems of inability to achieve glucose levels, patient inconvenience, pain, etc., and achieve good skin puncture effect, relieve pain, and achieve the effect of tiny needles

Active Publication Date: 2020-09-08
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional blood sugar detection needs to prick the finger to draw blood, repeated needle pricking blood
This method of blood sugar testing and drug injection not only brings inconvenience and pain to patients, but also requires long-term compliance
More importantly, the conventional treatment without direct coupling of glucose sensing and drug therapy cannot achieve strict regulation of the patient's glucose level.

Method used

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  • A 3D printed microneedle patch for intelligent blood sugar regulation and its preparation method
  • A 3D printed microneedle patch for intelligent blood sugar regulation and its preparation method
  • A 3D printed microneedle patch for intelligent blood sugar regulation and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of the medicine of embodiment 1 intelligent regulation blood sugar

[0032] (1) According to the method described in the applicant's previous patent application "Gold Nanocluster Particles for Intelligently Released Insulin to Regulate Blood Sugar and Its Preparation Method" (Application No. 201810075085.8, Publication No. CN 108079282A) to prepare a smartly released insulin for regulating blood sugar Gold nanocluster particles (GNC-FPBA-Insulin or GNC-PBA-Insulin).

[0033] (2) Preparation of gold nanocluster particles (BSA-GNC-PBA-Insulin) responsive to blood glucose regulation

[0034] 1) Preparation of BSA-coated gold nanocluster particles (BSA-GNCs)

[0035] Contains HAuCl 4 . The BSA mixed solution was reacted at 35-40° C. for 10-18 h under the condition of pH ≥ 12 to obtain BSA-coated gold nanocluster particles (BSA-GNCs).

[0036] 2) Convert the amino groups on the surface of BSA to carboxyl groups

[0037]First add glutaraldehyde to the BSA-...

Embodiment 2

[0045] Example 2 Preparation and Application of Microneedle Patch for Smart Blood Sugar Regulation

[0046] (1) Modeling of 3D printed microneedle patches

[0047] Use modeling software (Solidworks or autoCAD, etc.) to build a three-dimensional model of the microneedle patch, and export it into an STL file format ( figure 1 a-b). Import the model into the printing software of the 3D printer and check the correction data.

[0048] The design and size of the three-dimensional model of the microneedle patch are as follows: figure 1 shown. The microneedle patch consists of two main parts, the substrate and the microneedle array. The microneedle array contains 11×11 conical structures ( figure 1 a-b), the diameter of each cone base is 300-400μm (d1), and the diameter of the cone top is 25μm (d2) (note: determined by the precision of SLA technology, its minimum resolution can only reach 25μm, and cannot reach smaller Size), the height is 600-800μm(h1), the distance between adj...

Embodiment 3

[0077] Example 3 Preparation and Application of Microneedle Patch for Intelligent Blood Sugar Regulation

[0078] In Example 2, the photosensitive material for preparing the microneedle patch by 3D printing is GelMA, and the photosensitive material for preparing the microneedle patch in this example is formylated hyaluronic acid (m-HA).

[0079] Hyaluronic acid is a natural polymer material with excellent biocompatibility. Formylated hyaluronic acid (m-HA) is a photosensitive biological hydrogel material obtained by reacting hyaluronic acid (HA) with methacrylic anhydride. Add N,N'-methylenebisacrylamide (MBA) and photoinitiator (I2959) to m-MA, and irradiate with ultraviolet light (365nm) for a certain period of time to undergo photocrosslinking and curing.

[0080] The specific method of 3D printing microneedle patch is as follows:

[0081] Prepare mass percentage 4% (2%-10%, preferably 4%) m-HA, 2% (2%-5%, preferably 2%) N,N'-methylenebisacrylamide (MBA) and 0.5% (0.05%-...

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Abstract

The invention discloses a 3D printed microneedle patch for intelligent blood sugar regulation and a preparation method thereof, belonging to the field of biomedicine. The 3D printed microneedle patch of the present invention is mainly made of photosensitive materials with good biocompatibility, including two parts: a substrate and a microneedle array. The microneedle array contains a plurality of conical microneedles, and the microneedles contain intelligent adjustment A drug for blood sugar, the drug includes a carrier material, a glucose-responsive sensitive switch factor, and a drug molecule. First use modeling software to build a three-dimensional model of the microneedle patch, and import the model into the printing software of the 3D printer; then use the 3D printing technology of photocuring to make the photosensitive material solution containing photoinitiator and drug press the microneedle patch in three dimensions The structure of the model is solidified to obtain a 3D printed microneedle patch. The microneedle patch of the present invention can puncture the skin, and intelligently release the contained insulin in the body according to the blood sugar concentration, so as to intelligently regulate the blood sugar level. The invention realizes painless and intelligent response blood sugar regulation.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a 3D printed microneedle patch for intelligent blood sugar regulation and a preparation method thereof. Background technique [0002] Diabetes mellitus is a metabolic disease in which high glucose in the body is caused by insufficient insulin secretion or impaired insulin biological action. Among them, type 1 diabetes is due to autoimmune destruction of pancreatic beta cells leading to insufficient insulin secretion, and type 2 diabetes is a combination of insulin resistance and impaired insulin secretion. In recent years, diabetes has become an increasingly serious threat to public health in the world. According to statistics, in 2017, there were about 425 million adults with type 1 and type 2 diabetes worldwide. [0003] For patients with type 1 diabetes and advanced type 2 diabetes, the traditional treatment method is to use finger blood collection, blood sugar detection, and subc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0053A61M2037/0023B33Y80/00B33Y10/00
Inventor 雷祎凤刘胜张玉洁李银萍
Owner WUHAN UNIV
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