Detection analyzer

A technology for analyzers and samples, applied in the field of detection analyzers, can solve problems such as permanent cell damage and quantitative statistics, and achieve the effect of avoiding deception, avoiding time waste and ensuring accuracy

Active Publication Date: 2019-01-04
宁波慈溪生物医学工程研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the shortcomings of traditional biotoxicity detection methods: 1) Quantitative statistics, semi-quantitative detection; 2) Chemical dyes will cause permanent damage to cells; 3) Time-point analysis method

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1 detection analyzer

[0049] Such as figure 1 , which shows a schematic workflow diagram of the multimodal, dynamic biotoxicity real-time quantitative detection analyzer.

[0050] Among them, the function of the oscillator 1 is to drive the vibration platform 2 (piezoelectric crystal) to vibrate at a fixed frequency through the applied alternating voltage. The oscillator 1 and the vibration platform 2 are in multi-point contact, using the deep positive feedback cross value, and controlling the driving frequency through the closing loop to meet the stress vibration mode of the low-error oscillator. Oscillator 1 drives vibration platform 2 to reach the resonant frequency, vibration platform 2 can also be collected by data acquisition system 5 and by processing software (such as dynamic amplitude normalization software and function simulation software) for data processing.

[0051] Vibration platform 2: Driven by the driving frequency of oscillator 1, it vib...

Embodiment 2

[0089] Example 2 Application

[0090] Preparation of nanoparticles

[0091] According to the method provided in the literature (Journal of Nanobiotechnology, 2017, 15(1): 23)), the sodium citrate reduction method is used to synthesize gold nanoparticles commonly used in nanomedicine. The specific steps are as follows: add 144ml super Pure water was heated to boiling, and then 3.5ml of sodium citrate (60mM) and 1.5ml of citric acid (60mM) were added and stirred vigorously. 100 μl of EDTA was added, followed by 1 ml of chloroauric acid (25 mM). When the color of the mixture turns to wine red, turn off the heating, and when it drops to a certain temperature, immerse it in ice water to stop the reaction. Synthesized spherical gold nanoparticles with a diameter of 13nm.

[0092] After ligand exchange, polyethylene glycol is coated on the surface of gold nanoparticles to improve the biocompatibility and stability of the nanoparticles.

[0093] Testing the maximum uptake of nanop...

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Abstract

The invention discloses a detection analyzer. The detection analyzer incudes a first sample input / output element, a second sample input / output element, a sample cabin, an oscillation platform, an oscillator, a data collection system and a data display; the first sample input / output element and the second sample input / output element are communicated with the sample cabin separately; the oscillationplatform is located inside the sample cabin; the oscillator is located outside the sample cabin and is connected with the oscillation platform; the data collection system is located outside the sample cabin and is connected with the oscillation platform; the data display is connected with the data collection system.

Description

technical field [0001] The present application relates to a detection analyzer, in particular to an analyzer for real-time quantitative detection of multimodal and dynamic biological toxicity. Background technique [0002] At present, MEMS is a relatively popular technology, which is a frontier subject based on micro / nano technology. By designing, processing, manufacturing and controlling micro / nano materials, mechanical construction, optical system, drive components, electronic control system, and digital processing system can be integrated into an overall unit. This kind of MEMS can not only collect, process and send information or instructions, but also take actions independently or according to external instructions according to the acquired information. It is a manufacturing process combining microelectronics technology and micromachining technology, which can be used to produce various sensors, actuators, drivers and microsystems with excellent performance, low price ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15G01N35/00
CPCG01N33/15G01N35/00584
Inventor 杨方吴爱国马园园
Owner 宁波慈溪生物医学工程研究所
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