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Maternal-fetal blood group incompatibility treatment device based on clearance of pathogenic antibodies

A treatment device and a technology for incompatibility of blood types, applied in the medical field, can solve the problem of not raising Rh-positive "O" type red blood cells, etc., and achieve the effect of saving blood source and increasing fusion rate

Inactive Publication Date: 2019-01-08
翁炳焕
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Theoretically, this treatment method is obviously superior to the existing treatment methods, but the problem is that these literatures have not yet proposed an in vitro expansion method for Rh-positive "O" red blood cells, and the Rh-positive "O" type human used Red blood cells or rhesus monkey red blood cells can only be taken directly from Rh-positive humans or rhesus monkeys
The applicant also tried to find or trial-produce non-red blood cell materials capable of absorbing Rh antibodies, but so far failed

Method used

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  • Maternal-fetal blood group incompatibility treatment device based on clearance of pathogenic antibodies
  • Maternal-fetal blood group incompatibility treatment device based on clearance of pathogenic antibodies
  • Maternal-fetal blood group incompatibility treatment device based on clearance of pathogenic antibodies

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Embodiment Construction

[0015] figure 1 It is a hybrid cell clone diagram prepared by the present invention.

[0016] figure 2It is the immunoagglutination diagram of the hybrid cell and Rh antibody prepared in the present invention.

[0017] image 3 It is a schematic diagram of the treatment device for maternal-fetal blood group incompatibility based on hybrid strains to eliminate pathogenic antibodies of the present invention.

[0018] Figure 4 It is a schematic diagram of the internal structure of the plasma separator proposed according to the present invention.

[0019] Figure 5 It is a schematic diagram of the internal structure of the adsorber proposed according to the present invention

[0020] exist figure 1 Among them, Rh positive "O" type bone marrow cells are differentiated by erythropoietin-directed induction and immature red blood cell line. Under the action of PEG, after fusion with myeloma cells, they are screened by HAT for 1 to 2 weeks and viewed under an inverted microsco...

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Abstract

A maternal-fetal blood group incompatibility treatment device based on clearance of pathogenic antibodies for use in the medical field is characterized in that, erythropoietin is used as inducer, ''O'' type human or monkey bone marrow cell positive for Rh were cultured, to increase the number of directionally developing erythroid cells, human or monkey bone marrow cells were fused with mouse or human myeloma cells to form hybridized cells, different concentrations of erythropoietin were selected according to different fusion cells, to induce the directional differentiation of hybridized cells,Hybrid cell clones were screened by HAT, The hybridization strains of Rh positive cells which can be expanded indefinitely in vitro were screened by Rh antibody, after industrial amplification, it isused as an adsorbent to make an adsorber and then a blood separator to form an in vitro therapeutic device. By adsorbing the pathogenic Rh antibody in maternal and fetal blood group incompatible maternal plasma, a cheap and safe method for the treatment of maternal and fetal blood group incompatible hemolytic disease without removing the plasma and its beneficial ingredients is established.

Description

technical field [0001] The invention relates to the preparation of a hybrid strain for the treatment of maternal-fetal blood group incompatibility in the field of medicine, and further, a therapeutic device for maternal-fetal blood group incompatibility based on eliminating pathogenic antibodies made based on the prepared hybrid strain, which is mainly used for the detection of anti-fetal red blood cell antibodies in the plasma of pregnant women with maternal-fetal Rh blood group incompatibility Adsorption removal. Background technique [0002] Humans have 26 blood types such as ABO, Rh, MN, Lew, and Kell, among which the most important are ABO blood type and Rh blood type. ABO blood type is divided into A according to the A antigen, B antigen, AB antigen or no A and B antigen carried by red blood cells Rh blood type, B type, AB type and O type; Rh blood type is divided into Rh positive and Rh negative according to whether red blood cells carry D antigen, Rh positive red blo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36
CPCA61M1/3633A61M2202/0413A61M2202/0429A61M2205/02A61M2210/12A61M1/362A61M1/3689A61M2202/0021A61M2202/0064
Inventor 翁炳焕朱小明江川苏岚陈丹青
Owner 翁炳焕
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