A kind of secondary/tertiary amide compound and its synthetic method

Abstract

The invention discloses a secondary / tertiary amide compound and a synthesis method thereof. Adding aryl silane and amine compounds, catalysts and additives to a solvent, and then introducing CO under a certain pressure for carbonylation reaction, and then separating and purifying the compound. This gives secondary / tertiary amides. The method for preparing secondary / tertiary amides by carbonylation reaction of the present invention is simple and efficient, has direct reaction, high atom economy, and wide and stable substrate sources. The reaction system of the invention does not require inert gas protection, and the conditions are mild. Under optimized reaction conditions, the target product is easy to separate, and the yield is as high as 92%.

Description

technical field

[0001] The invention belongs to the field of organic synthesis, and in particular relates to a secondary / tertiary amide compound and a synthesis method thereof. Background technique

[0002] Amide compounds widely exist in natural products and drug molecules, and are an important class of chemical skeletons. Traditional synthesis of amides is based on the condensation of amines and carboxylic acid derivatives [a) Constable, D.J.C.; Dunn, P.J.; Hayler, J.D.; Humphrey, G.R.; Leazer, J.J.L.; Linderman, R.J.; Lorenz, K. ; Manley, J.; Pearlman, B.A.; Wells, A.; Zaks, A.; Zhang, T.Y. Green Chem.2007, 9, 411-420.b) Wu, X.-F.; Chem. 2007, 72, 765-774.]. However, such methods often require harsh reaction conditions, such as reaction under acidic or high temperature conditions. In recent years, there have been many novel methods for the synthesis of amides, such as using halogenated hydrocarbons, arylboronic acids, etc. as substrates, [c) Langer, P., et al.Synthesis...

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