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Calibrators, corresponding methods and applications for both anion and cation detection modes

A technology of cations and calibrants, which is applied in the field of ion mobility spectrometry, can solve the problems of easy mutual interference of the chemical properties of the calibrator and increase the complexity of the gas system, and achieve the effect of simplifying the gas system and simplifying the calibration process

Active Publication Date: 2021-04-23
THE THIRD RES INST OF MIN OF PUBLIC SECURITY
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Problems solved by technology

[0003] However, in an instrument that detects anion and cation at the same time in a single ion transfer tube, it is necessary to install different calibrators in the anion and cation detection modes in a set of gas circuit system, which not only increases the complexity of the gas circuit system, but also increases the complexity of the gas circuit system. The calibrators are chemically prone to interfere with each other

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  • Calibrators, corresponding methods and applications for both anion and cation detection modes
  • Calibrators, corresponding methods and applications for both anion and cation detection modes
  • Calibrators, corresponding methods and applications for both anion and cation detection modes

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Embodiment Construction

[0014] In order to describe the technical content of the present invention more clearly, further description will be given below in conjunction with specific embodiments.

[0015] Such as Figure 1~3 As shown, the present invention uses nicotinamide as a calibrator to realize simultaneous calibration in two modes of anion detection and cation detection in a single ion transfer tube, wherein the calibrator nicotinamide can produce anion and cation peaks (such as Figure 2~3 shown), the approximate mobility of the cationic peak is 1.745cm 2 / V. s, the reduced mobility of the anion peak is 1.689cm 2 / V. s. The detection limits of nicotinamide in negative and positive ion detection modes are on the order of 300ng and 100ng, respectively.

[0016] Due to the difference in the detection limit of nicotinamide in the two detection modes, in the single ion migration tube according to the cation peak migration time t of nicotinamide n , Calculate the anion peak migration time t of...

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Abstract

The invention relates to a calibrator suitable for both anion and cation detection modes, and the calibrator is nicotinamide. The invention provides a method for calibrating based on the calibrator suitable for negative and positive ion detection modes. The invention also provides an ion mobility spectrum. Using the calibrator, corresponding method and application applicable to both anion and cation detection modes of the present invention, nicotinamide (Nicotinamide) is used as the calibrator, which can realize simultaneous calibration in both anion detection and cation detection modes, making the calibration process more efficient Simple, and simplify the air system at the same time.

Description

technical field [0001] The present invention relates to the technical field of ion mobility spectrometry, in particular to the technical field of calibrator, and specifically refers to a calibrator suitable for both anion and cation detection modes, a corresponding method and an application. Background technique [0002] At present, trace detection instruments based on ion mobility spectrometry generally use different calibrators for anion and cation detection. For example, in U.S. Patent US7709788, 2,6-di-tert-butyl-4-methylphenol (commonly known as BHT, molecular formula C 15 h 24 O) and 5-nitrovanillin as calibration substances in negative ion mode. The instrument for detecting cations generally uses ammonium salt as the calibrator, such as ammonium carbamate, ammonium carbonate or ammonium bicarbonate as calibrator and reactant in US2009 / 0166531, and ammonium sulfate, ammonium chloride or ammonium nitrate in patent US8461517 as calibrator and reactant. [0003] Howev...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/622
CPCG01N27/622
Inventor 金洁疏天民沈俊
Owner THE THIRD RES INST OF MIN OF PUBLIC SECURITY