Method for extracting saponins component from Yixinshu composition by supercritical fluid extraction method

A supercritical extraction method and saponin technology, which is applied to plant/algae/fungi/moss components, medical preparations containing active ingredients, drug combinations, etc. The extraction rate and purity cannot meet the problems of production and use, so as to achieve the effects of easy preparation, reduced drug dosage and good therapeutic effect

Inactive Publication Date: 2019-01-18
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there are many kinds of active ingredients of medicines that need to be extracted, the active ingredients of Yixinshu preparations obtained through the above-mentioned traditional preparation process are basically crude extr

Method used

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  • Method for extracting saponins component from Yixinshu composition by supercritical fluid extraction method
  • Method for extracting saponins component from Yixinshu composition by supercritical fluid extraction method
  • Method for extracting saponins component from Yixinshu composition by supercritical fluid extraction method

Examples

Experimental program
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Example Embodiment

[0034] Example 1 of the present invention: A supercritical extraction method for extracting saponins in the Yixinshu composition is: pulverizing ginseng, Ophiopogon, Schisandra, Astragalus, Danshen, Ligusticum chuanxiong and Hawthorn to 1.0 mm, and drying at low temperature, According to the weight of the prescription, extract separately or after mixing; supercritical carbon dioxide is used as the extractant, the entrainer is 80% ethanol, the pressure is 40MPa, the temperature is 50℃, the carbon dioxide flow is controlled at 25L / h, and the extraction is 3h. Obtain the first raffinate; then use 70% ethanol as the entrainer, the pressure is 30MPa, the temperature is 50℃, the carbon dioxide flow is controlled at 30Kg / h, and the first raffinate is extracted for the second time for 3h , Get the second raffinate; then use 95% ethanol as the entrainer, the pressure is 40MPa, the temperature is 45℃, the carbon dioxide flow is controlled at 10Kg / h, the second raffinate is extracted for t...

Example Embodiment

[0035] Example 2 of the present invention: A method for supercritical extraction of saponins in the Yixinshu composition is: pulverizing ginseng, Ophiopogon, Schisandra, Astragalus, Danshen, Ligusticum chuanxiong and Hawthorn to 0.3 mm, and drying at low temperature, Weigh it according to the weight of the prescription, and extract it separately or after mixing; supercritical carbon dioxide is used as the extractant, the entrainer is acetone, the pressure is 30MPa, the temperature is 40℃, the carbon dioxide flow is controlled at 10L / h, and the extraction is 2h. The first raffinate; then 60% ethanol is used as the entrainer, the pressure is 20MPa, the temperature is 40℃, the carbon dioxide flow is controlled at 10Kg / h, and the first raffinate is extracted for the second time, and the extraction is 2h. The second raffinate; 70% ethanol is used as the entrainer, the pressure is 20MPa, the temperature is 40℃, and the carbon dioxide flow is controlled at 20Kg / h. The second raffinate ...

Example Embodiment

[0036] Example 3 of the present invention: A supercritical extraction method for extracting saponins in the Yixinshu composition is: pulverizing ginseng, Ophiopogon japonicus, Schisandra, Astragalus, Salvia Miltiorrhiza, Ligusticum chuanxiong and Hawthorn to 2.0 mm, and drying at low temperature. Weigh separately or mix according to the weight ratio of the prescription for extraction; use supercritical carbon dioxide as extractant, entrainer is ethyl acetate, pressure is 50MPa, temperature is 60°C, carbon dioxide flow is controlled at 30L / h, extraction is 4h, Obtain the first raffinate; then use 80% ethanol as the entrainer, the pressure is 25MPa, the temperature is 60℃, the carbon dioxide flow is controlled at 20Kg / h, and the first raffinate is extracted for the second time for 4h , Get the second raffinate; then use 85% ethanol as the entrainer, the pressure is 30MPa, the temperature is 60℃, the carbon dioxide flow is controlled at 30Kg / h, the second raffinate is extracted for...

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Abstract

The invention relates to a method for extracting a saponins component from Yixinshu composition by a supercritical fluid extraction method and a product thereof, and specifically relates to pulverizing ginseng, radix Ophiopogonis, fructus Schisandrae Chinensis, radix astragali, radix Salviae Miltiorrhizae, rhizoma Ligustici Chuanxiong and fructus crataegi to 0.3-2.0 mm in prescription amount, drying at low temperature, extracting separately or mixing. The saponins in Yixinshu preparation were extracted with supercritical carbon dioxide as extractant, which provided saponins effective ingredients for the development of new preparation.

Description

technical field [0001] The invention relates to a method for extracting active ingredients in a Yixinshu composition by a supercritical extraction method and a product thereof, belonging to the technical field of preparation of Yixinshu preparations. Background technique [0002] Yixinshu preparation has the functions of replenishing qi and recovering pulse, promoting blood circulation and removing blood stasis, nourishing yin and promoting body fluid. It is used for Qi and Yin deficiency, palpitations, pulse knots, chest tightness, chest pain, and angina pectoris of coronary heart disease. According to literature reports, more than 20 million people die of cardiovascular and cerebrovascular diseases in the world every year, and nearly 400,000 in my country. Traditional Chinese medicine has accumulated rich clinical experience in the diagnosis and treatment of this disease, and traditional Chinese medicine prescriptions have unique advantages in the treatment of cardiovascul...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P9/10
CPCA61K36/258A61K36/236A61K36/481A61K36/537A61K36/57A61K36/734A61K36/79A61K36/8968A61K2236/37A61K2236/39A61P9/10A61K2300/00
Inventor 安怀略
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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