Lactobacillus rhamnosus with fatty liver disease inhibiting function and application thereof

A technology of Lactobacillus rhamnosus and fatty liver, which is applied in the field of microbiology and can solve the problems that the efficacy of Lactobacillus rhamnosus colitis has not been reported.

Active Publication Date: 2019-01-25
NANCHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the efficacy of Lactobacillus rhamnosus in alleviating colitis

Method used

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  • Lactobacillus rhamnosus with fatty liver disease inhibiting function and application thereof
  • Lactobacillus rhamnosus with fatty liver disease inhibiting function and application thereof
  • Lactobacillus rhamnosus with fatty liver disease inhibiting function and application thereof

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experiment example

[0015] Below in conjunction with accompanying drawing and experimental example, test data, the present invention is described in detail:

[0016] Healthy SD rats, male, weighing 120-150 g, were placed in a feeding environment for adaptation for 1 week. Rats were randomly divided into normal group (ND), high fat model group (HFD), Lactobacillus rhamnosus CGMCC NO.11886 low dose group (108CFU / mL) and Lactobacillus rhamnosus CGMCC NO.11886 high dose group (109CFU / mL) 4 groups, 10 rats in each group. All rats drank water normally, and were given high-fat diets in the model group, high-dose group and low-dose group. According to 10mL / kg body weight, the high-dose group and the low-dose group were given the corresponding dose of Lactobacillus rhamnosus CGMCC NO.11886, and the high-fat model group and the normal group were given the same dose of normal saline, for 5 consecutive weeks. After the experiment, the rats were anesthetized by chloral hydrate, blood was collected by heart ...

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Abstract

The invention discloses lactobacillus rhamnosus with a fatty liver disease inhibiting function and application thereof. A strain, L. rhamnosus NCU2217, is collected, with the collection number CGMCC NO15573, in the China General Microbiological Culture Collection Center on April 9, 2018. The address of the China General Microbiological Culture Collection Center (referred to as CGMCC) is Instituteof Microbiology, Chinses Academy of Sciences, No. 3, No. 1 Courtyard, Beichen West Road, Chaoyang District, Beijing, China. The L. rhamnosus and food prepared therefrom have the effects of inhibitingliver function damage, reducing liver fat accumulation, improving the microstructures of fatty livers and promoting liver damage repair on non-alcoholic fatty liver diseases induced by high-fat diet.

Description

technical field [0001] The invention belongs to the field of microorganisms, and in particular relates to a strain of Lactobacillus rhamnosus capable of inhibiting fatty liver disease and its application. Background technique [0002] Lactobacillus rhamnosus is a probiotic lactic acid bacterium that has been widely studied abroad in recent years, and it widely exists in traditional fermented dairy products and the human gastrointestinal tract. A large amount of data have shown that Lactobacillus rhamnosus has broad development and application prospects in the field of probiotics. The current research results have confirmed that Lactobacillus rhamnosus has the following beneficial functions: (1) antibacterial effect. According to reports, Lactobacillus rhamnosus has inhibitory effects on some pathogenic bacteria in food and intestines, and the antibacterial substances produced by its fermentation have inhibitory effects on Gram-positive, negative bacteria and various pathoge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L19/20A23L2/38A23L33/135A23C9/123A23C9/152A23C9/16C12N1/20C12R1/225
CPCA23C9/1234A23C9/152A23C9/16A23C19/061A23L2/382A23L19/20A23L33/135A23V2002/00C12R2001/225C12N1/205A23V2400/175A23V2200/32Y02A50/30
Inventor 熊涛谢明勇关倩倩黄涛
Owner NANCHANG UNIV
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