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Cyclic peptide compound, preparation method and applications thereof

A technology of compound and cyclic peptide, which is applied in the field of cyclic peptide compound and its preparation, can solve the problem of low success rate of antibacterial active ingredients, and achieve the effect of wide application and good antibacterial activity

Active Publication Date: 2019-01-25
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the existence of microbial silencing gene clusters, most monomeric compounds cannot be expressed under common culture conditions, and the success rate of seeking novel antibacterial active ingredients through traditional methods is getting lower and lower. Therefore, how to effectively induce silencing genes Expression and production of novel active monomers have become a research hotspot

Method used

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  • Cyclic peptide compound, preparation method and applications thereof
  • Cyclic peptide compound, preparation method and applications thereof
  • Cyclic peptide compound, preparation method and applications thereof

Examples

Experimental program
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Embodiment 1

[0020] Embodiment 1, structural formula is the preparation of formula I compound

[0021] The present invention adopts the steps of microbial fermentation, extraction, purification and the like under rare earth element co-cultivation conditions to prepare the compound of the present invention. The bacterial strain used therein is Penicillium citrinum. This bacterial strain is isolated from marine sponges and is a symbiotic microorganism of marine sponges. It is placed in 20% glycerin aqueous solution and stored in a refrigerator at minus 80°C. The selected medium is the improved potato medium.

[0022] Preparation of potato medium: Weigh 200g of peeled potatoes, cut into pieces, place in 1000mL of artificial seawater, boil for 30 molecules, filter, fill up to 1000mL with artificial seawater, add 0.35g of magnesium sulfate, 0.5g of scandium chloride, 121°C Sterilize for 30 minutes. Add 2% agar to the liquid medium when preparing solid medium. Among them, 30.0g sea salt is d...

Embodiment 2

[0038] Embodiment 2 The antibacterial activity of compound I of the present invention

[0039] 1) Experimental materials

[0040] Instruments and reagents: CO 2 Incubator; Microplate reader (Bio-TEKELx800); LB medium (Shanghai Bioengineering Co., Ltd.).

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Abstract

The invention discloses a cyclic peptide compound having a structure represented by a formula I, a preparation method and applications thereof, wherein the formula I is defined in the specification. According to the present invention, the secondary metabolites of marine symbiotic fungi are separated and purified by using a microbial rare earth element co-culture technology to obtain the compound,and the in vitro antibacterial test results prove that the compound has good antibacterial activity, can be used as the active component of antibacterial infectious drugs, and has wide uses.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a cyclic peptide compound, a preparation method thereof and a medical application of the compound. Background technique [0002] With the abuse of antibiotics and the emergence of super bacteria, bacterial infection is one of the main diseases that endanger human health. Research and development of new antibiotics has always been an important research content in the field of medicine. In recent years, natural products have gradually become an important source of effective active ingredients for human research. In the process of new drug development, on the one hand, natural products with good activity can be directly used clinically; Finding and developing new high-efficiency and low-toxicity drugs by means of organic synthesis and structural modification is one of the most effective ways to develop new drugs that has been proven in practice. [0003] As an important component in the...

Claims

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Application Information

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IPC IPC(8): C07K5/12C12P21/02A61K38/12A61P31/04C12R1/80
CPCA61K38/00A61P31/04C07K5/123C12P21/02
Inventor 李建林顾雨芹魏来来陈广通宋妍
Owner NANTONG UNIVERSITY
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