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PGS/PCL (poly(glycerol sebacate)/polycaprolactone) double-layer artificial vessel with meshed sheath structure and construction method thereof

A technology of artificial blood vessels and construction methods, applied in medical science, prostheses, etc., to achieve the effect of strong clinical transformation ability

Active Publication Date: 2019-02-01
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a PGS / PCL double-layer artificial blood vessel with a reticular sheath structure and a construction method thereof for the above-mentioned problems existing in the existing artificial blood vessel

Method used

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  • PGS/PCL (poly(glycerol sebacate)/polycaprolactone) double-layer artificial vessel with meshed sheath structure and construction method thereof
  • PGS/PCL (poly(glycerol sebacate)/polycaprolactone) double-layer artificial vessel with meshed sheath structure and construction method thereof
  • PGS/PCL (poly(glycerol sebacate)/polycaprolactone) double-layer artificial vessel with meshed sheath structure and construction method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The construction method of the PGS / PCL double-layer artificial blood vessel of mesh sheath structure, the steps are as follows:

[0036] S1. Dissolve polycaprolactone in 2,2,2-trifluoroethanol, dissolve at 50°C-55°C for 2 hours, then shake for 1 hour to form a uniform polycaprolactone-trifluoroethanol mixed solution. use;

[0037] Among them, 0.14g of polycaprolactone is dissolved in every 100mL of 2,2,2-trifluoroethanol;

[0038]In this example, 0.035 mg of polycaprolactone was dissolved in 25 μL of 2,2,2-trifluoroethanol;

[0039] S2. Using electrospinning technology, extract the polycaprolactone-trifluoroethanol mixed solution in S1 with a 1mL syringe connected to the syringe pump, and then fix the syringe containing the mixed solution on the syringe pump;

[0040] Then, adjust the distance between the spinning needle of the electrospinning machine and the receiving iron plate to be 25cm;

[0041] Adjust the advance speed of the syringe pump to 1.275mm / min;

[00...

Embodiment 2

[0053] The construction method of the PGS / PCL double-layer artificial blood vessel of mesh sheath structure, the steps are as follows:

[0054] S1. Dissolve polycaprolactone in 2,2,2-trifluoroethanol, dissolve at 50°C to 55°C for 2.5h, then shake for 1.5h to form a uniform polycaprolactone-trifluoroethanol mixed solution ,stand-by;

[0055] Among them, 0.14g of polycaprolactone is dissolved in every 100mL of 2,2,2-trifluoroethanol;

[0056] In this example, 0.035 mg of polycaprolactone was dissolved in 25 μL of 2,2,2-trifluoroethanol;

[0057] S2. Using electrospinning technology, extract the polycaprolactone-trifluoroethanol mixed solution in S1 with a 1mL syringe connected to the syringe pump, and then fix the syringe containing the mixed solution on the syringe pump;

[0058] Then, adjust the distance between the spinning needle of the electrospinning machine and the receiving iron plate to be 25cm;

[0059] Adjust the advance speed of the syringe pump to 1.275mm / min;

...

Embodiment 3

[0071] The construction method of the PGS / PCL double-layer artificial blood vessel of mesh sheath structure, the steps are as follows:

[0072] S1. Dissolve polycaprolactone in 2,2,2-trifluoroethanol, dissolve at 50°C to 55°C for 3 hours, then shake for 2 hours to form a uniform polycaprolactone-trifluoroethanol mixed solution. use;

[0073] Among them, 0.14g of polycaprolactone is dissolved in every 100mL of 2,2,2-trifluoroethanol;

[0074] In this example, 0.035 mg of polycaprolactone was dissolved in 25 μL of 2,2,2-trifluoroethanol;

[0075] S2. Using electrospinning technology, extract the polycaprolactone-trifluoroethanol mixed solution in S1 with a 1mL syringe connected to the syringe pump, and then fix the syringe containing the mixed solution on the syringe pump;

[0076] Then, adjust the distance between the spinning needle of the electrospinning machine and the receiving iron plate to be 25cm;

[0077] Adjust the advance speed of the syringe pump to 1.275mm / min; ...

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Abstract

The invention belongs to the technical field of preparation of artificial vessels and discloses a PGS / PCL (poly(glycerol sebacate) / polycaprolactone) double-layer artificial vessel with meshed sheath structure and a construction method thereof. The PGS / PCL double-layer artificial vessel is of double-layer tubular structure composed of porous and mutually communicated PGS and meshed PCL; a tube coreis made from poly(glycerol sebacate); polycaprolactone is wound outside the tube core to form a sheath. The PGS / PCL double-layer artificial vessel is made by means of electrostatic spinning. PCL spinning solution is formed by dissolving 0.14 g of polycaprolactone per 100 mL of 2,2,2-trifluoroethanol. An injection pump has a push speed of 1.275 mm / min; a rotating motor has a speed of 120 r / min. The PGS / PCL double-layer artificial vessel herein can act as part of a physiological vessel to guide a blood flow, can be reformed into a new vessel, which is close to the autogenous vessel in appearance, histologic performance and mechanical property, one year after implantation, and has high clinical converting capacity.

Description

technical field [0001] The invention belongs to the technical field of artificial blood vessel preparation, in particular to a PGS / PCL double-layer artificial blood vessel with a mesh sheath structure and a construction method thereof. Background technique [0002] Diseases such as coronary heart disease, arteriosclerotic occlusive disease of the lower extremities, dialysis treatment of chronic renal failure, and congenital malformations of cardiovascular diseases in children seriously threaten people's health. Effective and ideal treatment of these diseases requires a healthy blood vessel To replace the diseased blood vessels in the body. At present, there are two main types of transplanted blood vessels used clinically to replace diseased blood vessels in the body: (1) autologous blood vessels, including autologous arterial blood vessels and autologous venous blood vessels; (2) commercial artificial blood vessels constructed of polymers, such as Artificial blood vessels m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/50A61L27/56
CPCA61L27/18A61L27/50A61L27/507A61L27/56C08L67/04C08L67/00
Inventor 吴炜杨欣
Owner FOURTH MILITARY MEDICAL UNIVERSITY