N-myristoyltransferase (NMT)1, nmt2 and methionine aminopeptidase 2 overexpression in peripheral blood and peripheral blood mononuclear cells is a marker for adenomatous polyps and early detection of colorectal cancer

A myristoyl, peripheral blood single technique, used in biological testing, biomaterial analysis, biochemical equipment and methods, etc.

Inactive Publication Date: 2019-02-22
VASTCON
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However, blood tests may be more acceptable than stool tests or endoscopy

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  • N-myristoyltransferase (NMT)1, nmt2 and methionine aminopeptidase 2 overexpression in peripheral blood and peripheral blood mononuclear cells is a marker for adenomatous polyps and early detection of colorectal cancer
  • N-myristoyltransferase (NMT)1, nmt2 and methionine aminopeptidase 2 overexpression in peripheral blood and peripheral blood mononuclear cells is a marker for adenomatous polyps and early detection of colorectal cancer

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[0034] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are now described. All patent publications mentioned next are hereby incorporated by reference.

[0035] It was previously reported that NMT1, NMT2, and MetAP2 proteins were overexpressed in PBMCs of colorectal cancer patients compared with PBMCs of healthy controls due to positive immunostaining. Although detection of NMT1 was performed by using a polyclonal antibody raised against the full-length NMT1 protein, which has 77% amino acid sequence homology with NMT2. We also observed that the mRNAs of NMT2 and MetAP2 were higher in CRC patients compared with healthy controls.

[0036] Adenomatous polyps de...

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Abstract

Described herein is the identification of the NMT1, NMT2 and metAP2 genes, mRNA overexpressed in PBMCs of patients with adenomatous polyps in comparison with patients with non-adenomatous polyps and healthy controls. We also discovered that NMT2 levels are higher in the PBMCs of patients adenomatous polyps in comparison with patients with non-adenomatous polyps and healthy control subjects.

Description

[0001] Cross References to Related Applications [0002] This application claims the U.S. Provisional Patent Application entitled "'N-myristoyltransferase (NMT) 1, NMT2 and methionine aminopeptidase 2 overexpression in peripheral bloodmononuclear cells is a marker for adenomatous polyps and early detection of colorectal cancer" filed on May 3, 2016 Priority Serial No. 62 / 331,045, the entire contents of which are incorporated herein by reference. Background technique [0003] Cancer is the leading cause of death worldwide. Cancers of the colon, rectum, and appendix are collectively referred to as colorectal cancer (CRC). CRC is the second or third deadliest cancer worldwide, but has a 90% survival rate if treated early (Cancer Care Manitoba, 2007; Population screening for colorectal cancer, 2006). However, more than 600,000 people worldwide die from CRC each year (Canadian Cancer Society, 2010). [0004] CRC arises from premalignant adenomatous polyps that can take years to ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/573G01N33/574
CPCG01N33/573G01N33/57419G01N2333/91057G01N2333/948C12Q1/6883C12Q2600/158G01N2800/52
Inventor 谢丽·瓦尔玛·施里瓦斯塔夫安雷戈·施里瓦斯塔夫
Owner VASTCON
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