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Fat and medical uses thereof

A fat and usage technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, allergic diseases, etc., can solve the problems of increasing the overall cost of medical care

Pending Publication Date: 2019-03-01
LIPOGEMS INT SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Consequently, sepsis significantly increases the overall cost of healthcare

Method used

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  • Fat and medical uses thereof
  • Fat and medical uses thereof
  • Fat and medical uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0072] Mice and breeding conditions

[0073] All agreements are reviewed by the competent authority, the Institut Pasteur, to comply with French and European animal welfare regulations and public health service recommendations.

[0074] The mice used were C57B1 / 6RJRJ males 6 to 10 weeks old. If the inflammation score at any given point in time is greater than 21, or if the point attributable to respiration rate or quality increases by more than 3, the mouse is euthanized 22 . Unless otherwise stated, for each experiment, the total number of animals used in the non-CLP control is 5, and the CLP at the experimental point is 7. The group is 7. The experiment is always repeated twice independently. For LPS challenge, we used n=4 animals for control, n=8 animals for LPS, and n=8 animals for LPS+Lipogems group. The mice were reared in a pathogen-free facility with a 12:12 light / dark cycle with controlled temperature and humidity. Feel free to provide food and drinks. Always follow...

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PUM

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Abstract

The present invention refers to micro-fragmented fat or a composition comprising micro-fragmented fat for use in the treatment of a systemic disease, preferably associated to or caused by sepsis. Moreover, the micro-fragmented fat or the composition comprising micro- fragmented fat is used for treating a systemic, inflammatory, immune, or chronic disease, said disease being intended as a consequence of septic disease. Preferably, the micro-fragmented fat is useful for treating both the acute (early) and late stages of sepsis.

Description

Technical field [0001] The present invention relates to micro-fragmented adipose tissue or a composition containing micro-fragmented adipose tissue, which is used for the treatment of systemic diseases, preferably related to or caused by sepsis. [0002] In addition, the micro-fragmented adipose tissue or the composition containing the micro-fragmented adipose tissue is used to treat systemic, inflammatory, immunological or chronic diseases which are the result of septic diseases. [0003] Preferably, the micro-fragmented adipose tissue can be used to treat the acute (early) and late stages of sepsis. Background technique [0004] Sepsis or systemic inflammatory response syndrome is defined as a syndrome of physiological, pathological, and biochemical abnormalities induced by infection, leading to an uncontrolled systemic inflammatory response, causing vascular leakage, tissue damage, and multiple organ failure. Currently, because the available treatments are not very effective, sep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61K35/35A61P43/00
CPCA61K35/28A61K35/35A61P11/00A61P13/12A61P21/00A61P25/00A61P25/20A61P25/28A61P29/00A61P3/02A61P31/00A61P37/02A61P43/00A61P7/00A61K9/0043
Inventor C·F·M·特瑞莫拉德P·罗什托
Owner LIPOGEMS INT SRL