An active matter rapid infiltration system containing hemp extract or cannabidiol

A technology of cannabidiol and extract, which is applied in the field of rapid penetration system of active substances, can solve the problems of incomplete skin absorption, slow transmission speed of active ingredients, slow penetration rate, etc.

Inactive Publication Date: 2019-03-05
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at this stage, there is still the problem of slow transmission of active ingredients in drugs or cosmetics. Although the cosmetic formula contains piperine, it has not been combined with the delivery ingredients of drugs or cosmetics to promote the absorption of active ingredients in cosmetics.
[0013] Hemp extract or cannabidiol has good anti-inflammatory / free radical scavenging, lightening acne scars / repair damage, and anti-irritation effects, while applying hemp extract or cannabidiol to cosmetics will cause slower penetration rate, skin incomplete absorption defect

Method used

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  • An active matter rapid infiltration system containing hemp extract or cannabidiol
  • An active matter rapid infiltration system containing hemp extract or cannabidiol
  • An active matter rapid infiltration system containing hemp extract or cannabidiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] The preparation of embodiment 1 hemp extract

[0075] (1) Wash and air-dry the raw materials (marijuana leaves, cannabis flowers, hemp stalk core);

[0076] (2) pulverize the above-mentioned air-dried raw materials, and then pass through a 40-mesh sieve;

[0077] (3) The obtained powder was cold-soaked and extracted twice with 6 times the amount of 45% ethanol, each time for 1.5 hours;

[0078] (4) Combine extracts, decolorize through 0.5wt% activated carbon adsorption;

[0079] (5) Concentrate under reduced pressure to a relative density of 1.02 at a temperature of 70°C to obtain the cannabis extract.

[0080] According to the above preparation method,

[0081] When the raw material is cannabis leaves, the cannabis extract 1A is obtained;

[0082] When the raw material is cannabis flower, the cannabis extract 1B is obtained;

[0083] When the raw material is hemp stalk core, hemp extract 1C is obtained;

[0084] When the raw materials are cannabis leaves and cann...

Embodiment 2

[0086] The preparation of embodiment 2 hemp extract

[0087] (1) Use 9 times the amount of ethanol to heat and reflux the raw materials (marijuana leaves, hemp stalks, hemp flowers) for 1 hour;

[0088] (2) remove residue by filtration, and remove solvent under vacuum condition;

[0089] (3) heating the obtained extract at a temperature of 125° C. for 40 minutes;

[0090] (4) Carry out chromatographic separation subsequently, wherein mobile phase mixture is made up of ethanol / water and acetic acid, obtains cannabis extract.

[0091] According to the above preparation method,

[0092] When the raw material is cannabis leaves, cannabis extract 2A is obtained;

[0093] When the raw material is cannabis flower, the cannabis extract 2B is obtained;

[0094] When the raw material is hemp stalk core, hemp extract 2C is obtained;

[0095] Cannabis extract 2D is obtained when the raw materials are cannabis leaves and cannabis flowers;

[0096] Wherein, the content of the active s...

Embodiment 3

[0097] The preparation of embodiment 3 hemp extract

[0098] (1) Use 7 times the amount of ethanol to heat and reflux the raw materials (cannabis leaves, hemp stalks, hemp flowers) for 1.5 hours;

[0099] (2) filter to remove residue;

[0100] (3) extracting at least twice with 5% aqueous sodium hydroxide solution, wherein the aqueous sodium hydroxide solution contains 20wt% ethanol;

[0101] (4) The extract is mixed with 5% sulfuric acid solution to make the pH value 3;

[0102] (5) Then use aliphatic hydrocarbons to extract 2 times, and remove the solvent under low-temperature vacuum;

[0103] (6) Carry out chromatographic separation subsequently, wherein mobile phase mixture is made up of ethanol / water and acetic acid, obtains cannabis extract.

[0104] According to the above preparation method,

[0105] When the raw material is cannabis leaves, the cannabis extract 3A is obtained;

[0106] When the raw material is cannabis flower, the cannabis extract 3B is obtained; ...

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Abstract

The invention discloses an active matter rapid infiltration system containing hemp extract or cannabidiol to increase the release speed and skin absorption speed of cosmetics and preparations for external use containing hemp extract or cannabidiol. The invention further provides application of the hemp extract or cannabidiol in preparation of cosmetics, with the cosmetics being provided with the rapid infiltration system.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to an active substance rapid penetration system containing cannabis extract or cannabidiol. Background technique [0002] The transdermal absorption of functional ingredients in cosmetics refers to the process in which the active ingredients in cosmetics pass through the skin and reach different skin layers to exert various functions. The main difference between "transdermal absorption" of cosmetics and drugs is that the functional ingredients of cosmetics are accumulated in the active skin layer after permeation as the ultimate goal. Most functional ingredients of cosmetics need to enter the skin. They act on the surface of the skin or enter the epidermis or dermis according to the effectiveness of the product, where they accumulate and function, and do not need to enter the body circulation through the skin. [0003] Regarding the research on transdermal absorption, there are only many r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/365A61K8/34A61Q19/02A61P17/10
CPCA61K8/345A61K8/347A61K8/365A61K8/97A61Q19/02
Inventor 于朝晖张可谭昕吴亚南李萌
Owner HANYI BIO TECH CO LTD
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