A porous grade composite medical gel scaffold constructed by 3D printing and its preparation method

A 3D printing, porous-level technology, applied in the field of biomedical engineering materials, can solve the problems of reducing 3D printing efficiency, difficulty in sol shaping, difficulty in maintaining size, etc., to achieve good bone conduction, good biocompatibility, and good biological active effect

Active Publication Date: 2021-08-03
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method improves the strength of 3D printed alginic acid hydrogel, due to the long time of the first chemical crosslinking, the printed sol is difficult to shape, difficult to maintain the size, and prone to collapse. The operation in this process is cumbersome , greatly reducing the efficiency of 3D printing

Method used

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  • A porous grade composite medical gel scaffold constructed by 3D printing and its preparation method
  • A porous grade composite medical gel scaffold constructed by 3D printing and its preparation method
  • A porous grade composite medical gel scaffold constructed by 3D printing and its preparation method

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Experimental program
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Effect test

Embodiment 1

[0025] The porous-grade composite medical gel scaffold constructed by 3D printing in this embodiment is composed of the following raw materials according to the mass percentage: 7.6% of hydroxyapatite, 0.76% of mesoporous silica with a drug curcumin loading of 90%, Gluconolactone 15.3%, the balance is sodium alginate.

[0026] A method for preparing a porous-grade composite medical gel support constructed by 3D printing, comprising the following steps:

[0027] (1) Weigh 0.3g of hydroxyapatite (HAP) and add it to 30mL of deionized water, stir at room temperature for 30min to make HAP evenly dispersed, then add 3g of sodium alginate (SA) and continue stirring at room temperature for 2h to obtain a pre-crosslinking solution ;

[0028] (2) Add 0.03 g of drug-loaded mesoporous silica and 0.6 g of gluconolactone (GDL) to the pre-crosslinking solution obtained above, stir rapidly with a glass rod to obtain a slightly crosslinked hydrogel glue solution and fill it into a syringe, r...

Embodiment 2

[0032] The porous-grade composite medical gel scaffold constructed by 3D printing in this embodiment is composed of the following raw materials according to the mass percentage: 19.6% of hydroxyapatite, 1.96% of mesoporous silica with a drug curcumin loading of 90%, Gluconolactone 13.1%, the balance is sodium alginate.

[0033] The preparation method of the porous grade composite medical gel support constructed by 3D printing comprises the following steps:

[0034] (1) Weigh 0.9g of hydroxyapatite (HAP) and add it to 30mL of deionized water, stir at room temperature for 30min to make HAP evenly dispersed, then add 3g of sodium alginate (SA) and continue stirring at room temperature for 2h to obtain pre-crosslinked solution;

[0035] (2) Add 0.09 g of drug-loaded mesoporous silica and 0.6 g of gluconolactone (GDL) to the pre-crosslinking solution obtained above, stir rapidly with a glass rod to obtain a slightly crosslinked hydrogel glue solution and fill it into a syringe, r...

Embodiment 3

[0039] The porous-grade composite medical gel scaffold constructed by 3D printing in this embodiment is composed of the following raw materials according to the mass percentage: 28.9% of hydroxyapatite, 1.73% of mesoporous silica with a drug curcumin loading of 90%, Gluconolactone 11.6%, the balance is sodium alginate.

[0040] The preparation method of the porous-grade composite medical gel scaffold constructed by 3D printing in this embodiment comprises the following steps:

[0041] (1) Weigh 1.5g of hydroxyapatite (HAP) and add it to 30mL of deionized water, stir at room temperature for 30min to disperse HAP evenly, then add 3g of sodium alginate (SA) and continue to stir at room temperature for 2h to obtain the pre-mixed joint solution;

[0042] (2) Add 0.03 g of drug-loaded mesoporous silica and 0.6 g of gluconolactone (GDL) to the pre-crosslinking solution obtained above, stir rapidly with a glass rod to obtain a slightly crosslinked hydrogel glue solution and fill it ...

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Abstract

The invention discloses a porous grade composite medical gel scaffold constructed by 3D printing and a preparation method thereof. It is composed of the following raw materials according to the mass percentage: 7-30% of hydroxyapatite, and 0.7% of drug-loaded mesoporous silica ‑2%, gluconolactone 11‑16%, and the balance is sodium alginate. The present invention combines hydroxyapatite with alginate solution, and prepares alginate / hydroxyapatite hydrogel material through a simple composite gel approach, which can obtain good biological activity, compatibility, and drug loading and mitigation interpreted medical materials. The 3D printed gel solution in the present invention is added with drug-loaded mesoporous silica, which can play a thickening role and adjust the viscosity of the formula, so that the pre-crosslinked hydrogel can be printed under 3D printing conditions The gel stent is well formed; in addition, the drug load can realize the slow release of the drug, which can prevent the 3D stent from being contaminated by bacteria and play an antibacterial and sterilizing role.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, and in particular relates to a 3D-printed porous composite medical gel bracket and a preparation method thereof. Background technique [0002] In the field of biomedicine, organ and tissue transplantation and repair still face enormous difficulties and challenges. In recent years, 3D printing tissue engineering scaffold technology has played an increasingly important role in solving such problems. 3D printing tissue engineering scaffold technology is an emerging technology that combines three-dimensional rapid prototyping technology and tissue engineering technology to print scaffolds with good biocompatibility, excellent mechanical properties, ideal three-dimensional microstructure and controllable macroscopic shape. The scaffolds printed by this technology can be used for cell culture, allowing cells to grow, proliferate and differentiate in it to form tissues or organs with spe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/46A61L27/50A61L27/52A61L27/54A61L27/56A61L27/58B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/446A61L27/46A61L27/50A61L27/52A61L27/54A61L27/56A61L27/58A61L2300/21A61L2300/216A61L2300/232A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L5/04
Inventor 周武艺刘水凤胡洋张坚诚郑文旭董先明鲍思奇曾嘉欢
Owner SOUTH CHINA AGRI UNIV
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