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A kind of preparation method of hyaluronic acid or its salt granule and obtained product

A technology of hyaluronic acid and salt granules, which is applied in the field of hyaluronic acid granulation to achieve the effects of uniform particle size, good fluidity, and shortening of process routes and production cycles.

Active Publication Date: 2020-11-06
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no detailed report on the granulation of pure hyaluronic acid or its salt powder

Method used

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  • A kind of preparation method of hyaluronic acid or its salt granule and obtained product
  • A kind of preparation method of hyaluronic acid or its salt granule and obtained product
  • A kind of preparation method of hyaluronic acid or its salt granule and obtained product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]Pass sodium hyaluronate powder (raw material 1) through a 60-mesh vibrating sieve. Put the powder under the sieve into the dry granulator for granulation. The granulation conditions were set as follows: feed rate 40 r / min, roller speed 5 r / min, roller pressure 12 MPa, fine granulation speed 80 rpm, and the particle size of the screening system was set at 10 mesh and 40 mesh. The powder under the sieve is fed into the pressing roller at this feeding speed, pressed into thin slices, and then crushed into coarse particles. After fine granulation and two-stage sieving, the obtained coarse particles are discharged to obtain sodium hyaluronate particles.

Embodiment 2

[0028] Pass sodium hyaluronate powder (raw material 1) through a 60-mesh vibrating sieve. Put the powder under the sieve into the dry granulator for granulation. The granulation conditions were set as follows: feed rate 80 r / min, roller speed 12 r / min, roller pressure 15 MPa, fine granulation speed 80 rpm, and the particle size of the screening system was set at 10 mesh and 40 mesh. The powder under the sieve is fed into the pressing roller at this feeding speed, pressed into thin slices, and then crushed into coarse particles. After fine granulation and two-stage sieving, the obtained coarse particles are discharged to obtain sodium hyaluronate particles.

Embodiment 3

[0030] Pass sodium hyaluronate powder (raw material 1) through a 60-mesh vibrating sieve. Put the powder under the sieve into the dry granulator for granulation. The granulation conditions were set as follows: feed rate 30 r / min, roller speed 4 r / min, roller pressure 5 MPa, fine granulation speed 80 rpm, and the particle size of the screening system was set at 10 mesh and 40 mesh. The powder under the sieve is fed into the pressing roller at this feeding speed, pressed into thin slices, and then crushed into coarse particles. After fine granulation and two-stage sieving, the obtained coarse particles are discharged to obtain sodium hyaluronate particles.

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Abstract

The invention discloses a preparing method for hyaluronic acid or salt particles of the hyaluronic acid and an obtained product. The hyaluronic acid particle preparing method is a dry process granulation method, the hyaluronic acid or salt powder of the hyaluronic acid is subjected to rolling, pulverizing, fine granulating, screening and discharging through a dry process rolling and granulating method under the situation that a bonding agent is not used, and the hyaluronic acid or salt particles of the hyaluronic acid are obtained. The product has the characteristics of being high in stackingdensity, weak in hygroscopicity, good in mobility and stability and the like; and in the usage process, the advantages that dissolving is easy, adding is convenient, dust waste and pollution are reduced, long-term storage is achieved, and the transportation powdering ratio is low. According to the preparing method, operation is simple, little equipment is needed, a bonding agent and ingredients donot need to be added, influences on the structure and the property of the hyaluronic acid or the salt of the hyaluronic acid are avoided, and industrial production can be achieved.

Description

technical field [0001] The invention relates to a method for preparing hyaluronic acid or its salt particles, in particular to a method for preparing hyaluronic acid or its salt particles with good fluidity, high bulk density and low moisture absorption rate by adopting a dry rolling granulation process The obtained product belongs to the technical field of hyaluronic acid granulation. Background technique [0002] Hyaluronic acid (HA) is an acidic mucopolysaccharide composed of N-acetylglucosamine and D-glucuronic acid disaccharide repeating units through β-(1→4) glycosidic bonds and β-(1 →3) The unbranched polymer glycosaminoglycan composed of glycosidic bonds is a natural moisturizing factor. Its aqueous solution has the characteristics of high viscosity, film-forming properties and lubricity, so it is widely used in medicine, cosmetics, food and other fields. Usually 10 5 -10 7 Da (Dalton). [0003] Common hyaluronic acid or its salt raw materials on the market are w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29B9/04B29B9/12
CPCB29B9/04B29B9/12B29K2005/00
Inventor 冯宁宗文斌石艳丽郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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