Passive sleeping composition and application thereof

A composition and passive technology, applied in the directions of drug combination, drug delivery, plant raw materials, etc., can solve the problems of large side effects, inability to use for a long time, limited effect, etc., and achieve the effect of good application prospects.

Inactive Publication Date: 2019-04-12
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AI-Extracted Technical Summary

Problems solved by technology

[0011] In view of the above-mentioned technical problems, the embodiment of the present invention provides a passive hypnotic composition and its appl...
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Method used

[0030] Marjoram (Origanum majorana L) is an herb with a slightly pungent, bitter aroma. It has very high medicinal value and is widely used for the improvement of symptoms such as sedative spasm, headache or insomnia. The combination of lavender, marjoram, etc., with petitgrain, orange blossom, and sweet orange, which can relieve stress and relieve depression, can cooperate with each other to improve insomnia caused by stress.
[0046] The results of GC/MS gas chromatographic analysis of the pure essential oil for passive sleep...
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Embodiments of the invention disclose a passive sleeping composition and application thereof. The passive sleeping composition comprises Lavandula angustifolia, Origanum majorana L., sweet orange, andbitter orange leaves and flowers. The composition plays an effect of relieving stress and helping sleep through mutual combination of a variety of natural components. The composition acts on the central nervous system of a human body in a way of olfactory perception, has no side effects or the risk of addiction, can be used for a long time and has a good application prospect.

Application Domain

Nervous disorderPharmaceutical delivery mechanism +1

Technology Topic

Olfactory perceptionOriganum +5


  • Passive sleeping composition and application thereof
  • Passive sleeping composition and application thereof
  • Passive sleeping composition and application thereof


  • Experimental program(1)

Example Embodiment

[0025] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work shall fall within the protection scope of the present invention.
[0026] It should be noted that when an element is expressed as being "fixed to" another element, it can be directly on the other element, or there can be one or more elements in between. When an element is said to be "connected" to another element, it can be directly connected to the other element, or there may be one or more intervening elements in between. The terms "vertical", "horizontal", "left", "right", "upper", "lower", "inner", "outer", "bottom", etc. used in this manual indicate the orientation or positional relationship Based on the orientation or positional relationship shown in the drawings, it is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot It is understood as a limitation of the present invention. In addition, the terms "first", "second", etc. are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance.
[0027] Unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly understood by those skilled in the technical field of the present invention. The terms used in the specification of the present invention in this specification are only for the purpose of describing specific embodiments, and are not used to limit the present invention. The term "and/or" as used in this specification includes any and all combinations of one or more related listed items. In addition, the technical features involved in the different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.
[0028] The embodiment of the present invention provides a passive sleeping composition. Wherein, the passive sleeping composition includes the following components: Angu lavender, marjoram, sweet orange, bitter orange leaf and orange blossom.
[0029] Lavandula angustifolia (Lavandula angustifolia), also known as Lavender angustifolia, is a plant with a strong fragrance. It can be made into pillows and used as a mild tranquilizer to relieve stress and calm nerves.
[0030] Marjoram (Origanum majorana L) is an herb with a slightly pungent bitter aroma. It has a very high medicinal value and is widely used to relieve cramps, headaches or insomnia and other symptoms. The combination of lavender and marjoram, bitter orange leaves, orange blossoms and sweet oranges, which can relieve stress and relieve depression, can work together to improve insomnia caused by stress.
[0031] Specifically, calculated by weight percentage, in the passive sleeping composition, the ratio of the Angu lavender, marjoram, sweet orange, bitter orange leaves and orange blossom is 4:1:2:2:1, so as to obtain the best Good effect.
[0032] The passive sleeping composition provided by the embodiments of the present invention may be suitable for people who have difficulty falling asleep, late sleep, high pressure, irregular work and rest, frequent business trips, and often need to work overtime at night, resulting in insufficient sleep depth and time.
[0033] When used in the daytime, it can concentrate the user's mind and work more attentively. And after 8 o'clock in the evening, it can activate the parasympathetic nerve of the user, slow down the physical and mental activities, promote the increase of sleep depth, and improve the sleep problem of insufficient deep sleep caused by high pressure and late sleep.
[0034] Taking 100 patients who are too stressed and unable to fall asleep for more than 30 minutes when sleeping at night as an example, the results of an experimental study show that after using the passive sleeping composition, more than 85% of the patients have shortened the time to fall asleep, and 98% of them The patient’s brain waves showed that the time from the B wave to the alpha wave and then to the delta wave of deep sleep before going to bed was shortened, which confirmed that the time to fall asleep was shortened and the depth of sleep was increased, which can improve insomnia caused by emotional stress and enhance brain rest. Reduce anxiety levels.
[0035] Specifically, according to the above weight ratio, per 10 g of the passive sleeping composition, the following raw material components are included:
[0037] Surprisingly, when the above component ratios are used, the passive sleeping composition formed by mixing can have a better sedative and sleeping effect, and the various raw material components are better matched. This may be because when the raw material component ratios provided in the above examples are used (that is, the ratio of Angu lavender, marjoram, sweet orange, bitter orange leaves and orange blossom is 4:1:2:2:1), limonene (Limonene) The substance has the highest concentration.
[0038] Limonene is the most stress-relieving and anti-worry component widely used in emotional medicine. It also helps to promote parasympathetic nerves and let the brain enter a state of relaxation.
[0039] In a preferred embodiment, the passive sleeping composition may be formulated pure essential oil without dilution. It has high volatility and can directly play the role of biologically active substances in raw material components through the way of smell.
[0040] Specifically, the pure essential oil of the passive sleeping formula can be formed by mixing Angu lavender essential oil, marjoram essential oil, sweet orange essential oil, petitgrain essential oil and neroli essential oil in a set ratio. The set ratio can adopt the weight ratio disclosed in the above embodiments to obtain the best use effect.
[0041] Compared with traditional medicines or health products, the pure essential oils of the passive sleeping formula work through the human body’s sense of smell and nerve conduction, without any addictiveness. The effect is very fast and can relax muscles and nerves quickly. Coordinating the body's nervous system, so that when used during the day, it can help people enter a state of focused sympathetic secretion, and at night, it can help the body naturally enter the state of parasympathetic nerves, in a comfortable and relaxed state.
[0042] The specific principle and process are as follows: before the aromatic molecules are detected by the cilia of the olfactory nerve cells, they dissolve in the mucus. Afterwards, the olfactory induction of aromatic molecules will stimulate the parasympathetic nerves of the central nervous system in the form of electrical impulses through nerve fiber balls, which have reached muscle relaxation, decreased heart rhythm, slow breathing, and entered the pre-sleep state of preparation.
[0043] The region of the brain that controls the sense of smell is located in the mysterious limbic system. The limbic system, the hypothalamus and pituitary gland connected to it will be induced and stimulated by the outside world, thus triggering a series of mental and physical reactions in the human body. The olfactory sensing area in the brain is still the most basic and direct feeling. The limbic system is related to human instincts, such as emotion, intuition, memory, creativity, hunger, thirst, sleep state, and sexual desire.
[0044] Therefore, through suitable taste patterns, the sense of smell can play a physiologically active role, guide emotions, make them calm and relax, and help to better sleep.
[0045] Specifically, the first flavor of the pure essential oil of the passive sleeping formula is brought out by the combination of bitter orange leaf essential oil and neroli essential oil. Furthermore, Angu Lavender and Marjoram exude a relaxing grassland feel. The sweet taste of orange, blended with the vast and profound fragrance of flowers and herbs, is a relaxing and comfortable feeling. Use it 10 minutes before going to bed, you can let the brain waves from α wave to δ wave, enter relaxation and focus on breathing, and let the body naturally follow the operation of parasympathetic nerves into a stress-free sleep state.
[0046] The results of GC/MS gas chromatography analysis of the pure essential oil of passive sleeping formula showed that the anti-stress and anti-depressive limonene (Limonene) reached its highest peak after ten minutes. The chemicals used to induce cranial nerve relaxation and stimulate parasympathetic nerves, Linalool and Camphor, also appeared in sequence. The synergy between multiple substances is beneficial to reduce neuromuscular activity and can achieve a soothing and relaxing effect. It is suitable for people with high pressure, anxiety, difficulty falling asleep, and light sleep disorder.
[0047] In some embodiments, the essential oils can be dropped on the four corners of the pillows used for sleeping before going to bed, and a fragrance machine or the like can be used indoors to diffuse the essential oils to fill the room with a relaxing and soothing taste. In other embodiments, anion diffuser, bath, aromatherapy bag or diffuser stone can also be used in any other suitable ways to diffuse the flavor of essential oils during daily use.
[0048] figure 1 It is the type of brain waves in different states provided by the embodiments of the present invention (determined by detecting the change of the subject's scalp potential).
[0049] A brain wave test on users who used essential oils found that the subjects entered the alpha wave state when they were quiet and closed their eyes after the 5th minute of the test, and the brain activity was calm. Moreover, the subjects spent about 20 minutes longer in deep sleep than the average person in sleep.
[0050] Further experiments on passive sleeping essential oils in mice confirmed that the smell of the essential oil can play a significant sedative effect, can synergistically enhance the barbital-induced sleep time, anti-anxiety effect, reduce motility and prevent excessive activity caused by caffeine . Compared with hypnotics and tranquilizers, it has similar efficacy in treating insomnia, increasing sleepiness and promoting relaxation.
[0051] It can be understood that for those of ordinary skill in the art, equivalent replacements or changes can be made according to the technical solution of the present invention and the concept of the present invention, and all these changes or replacements shall fall within the protection scope of the appended claims of the present invention.


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