A method for the simultaneous detection of bisphenol A and phthalates based on ultra-high performance convergence chromatography
An ultra-efficient confluence and phthalic acid technology, applied in the field of chemical detection, can solve the problem that the simultaneous detection of bisphenol A and various phthalate plasticizers cannot be realized, the detection time is long, and the detection efficiency is low. problem, to achieve the effect of good application prospect, short detection time and high detection efficiency
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Embodiment 1
[0025] 1) Preparation of standard solution: Weigh bisphenol A and 18 kinds of phthalate standard products: BPA, BMPP, DIBP, DAP, DIPP, DPRP, DBP, DMP, DEHP, DHXP, DHP, DNOP, BBP , DNP, DPhP, DCHP, DBEP, DEEP and DMEP, use methanol to make standard solutions containing each standard substance, wherein the concentration range of each standard solution is 0.1~10.0mg / L, and filter with a 0.22 μm organic filter membrane, and set aside;
[0026] 2) Detection: Ultra-high performance convergence chromatography is used to carry out gradient elution on the standard solution and the sample solution, and the specification of the chromatographic column is ACQUITY UPC of 100mm×30 mm×1.7 μm 2For CSH BEH, column temperature is 65°C, system back pressure is 1800 psi, detection wavelength is 220 nm, mobile phase A is carbon dioxide and mobile phase B is acetonitrile; mobile phase elution gradient program is set as: 0~1 min, mobile phase The volume fraction of B increased from 3% to 4.5%, and th...
Embodiment 2
[0029] A method for simultaneously detecting bisphenol A and phthalate plasticizers, comprising the steps of:
[0030] 1) Preparation of standard solution: Weigh bisphenol A and 18 kinds of phthalate standard products: BPA, BMPP, DIBP, DAP, DIPP, DPRP, DBP, DMP, DEHP, DHXP, DHP, DNOP, BBP , DNP, DPhP, DCHP, DBEP, DEEP and DMEP, use methanol to make standard solutions with gradient concentrations of each standard substance, wherein the concentration range of each standard solution is 0.1~10.0 mg / L, and after filtering with a 0.22 μm organic filter membrane, spare;
[0031] 2) Preparation of sample solution: cut the food contact material sample into small particles with a mass of ≤0.02 g, then accurately weigh 0.5 g of the sample to be tested, put it in a 25 mL stoppered glass test tube, add 10 mL of methanol, and Extract at low temperature for 30 minutes, then filter the extract with a 0.22 μm organic filter membrane, concentrate to nearly dryness, dilute to 1 mL with methanol...
Embodiment 3
[0035] 1) Preparation of standard solution: Weigh bisphenol A and 18 kinds of phthalate standard products: BPA, BMPP, DIBP, DAP, DIPP, DPRP, DBP, DMP, DEHP, DHXP, DHP, DNOP, BBP , DNP, DPhP, DCHP, DBEP, DEEP and DMEP, use methanol to make standard solutions with gradient concentrations of each standard substance, wherein the concentration range of each standard solution is 0.1~10.0 mg / L, and after filtering with a 0.22 μm organic filter membrane, spare;
[0036] 2) Preparation of the sample solution: cut the food contact material sample into small particles with a mass of ≤0.01g, then accurately weigh 1.0 g of the sample to be tested, put it in a 25 mL stoppered glass test tube, add 10 mL of methanol, and Extract at low temperature for 100 min, then filter the extract with a 0.22 μm organic filter membrane, concentrate to near dryness, dilute to 1 mL with methanol, and set aside;
[0037] 3) Detection: The standard solution and the sample solution are gradiently eluted by ult...
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