Microangiography method and system based on optical fiber array multi-channel parallel detection
A technology of fiber optic array and fiber channel, which is applied in the fields of eye testing equipment, diagnostic recording/measurement, medical science, etc., can solve the problems of reduced lateral and axial resolution and achieve good connectivity
Active Publication Date: 2020-05-22
ZHEJIANG UNIV
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[0007] The purpose of the present invention is to provide a microangiography method based on multi-channel parallel detection of optical fiber array, which makes up for the deficiencies of the prior art, solves the problem of reduced lateral and axial resolution, and can make microvessels have better connectivity
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[0054] see figure 1 and figure 2 , the micro-angiography system based on fiber array multi-channel parallel detection in this embodiment includes a light source 1 , a reference arm 2 , a sampling arm 3 , a detection arm 4 and a computer 5 .
[0055] Wherein, the light source 1 is a superluminescent light emitting diode or a frequency-sweeping light source. The partially coherent light emitted by the light source 1 enters the fiber coupler 7 after passing through the fiber isolator 6, and the fiber coupler 7 divides the light emitted by the light source 1 into two paths, and one path of light enters the reference arm 2, and passes through the collimating lens and the reflector Reverse transmission, then enter the other end of the fiber coupler 7, decompose into multiple reference lights by the fiber coupler 8, each of the reference lights is connected to the reference light port of the fiber coupler array 11 after passing through the fiber polarization controller; Enter samp...
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The invention discloses a microangiography method and system based on optical fiber array multi-channel parallel detection, and belongs to the technical field of optical coherence tomography. The whole optical path structure is laid out according to a frequency domain optical coherence system, a sampling arm introduces signal light from a scanning area into an optical fiber array through a beam splitter; the output signal light and reference light of the optical fiber array are respectively accessed to an input end of a coupler array; an output end of the coupler array is connected with a corresponding detector to achieve parallel detection of coherent signals of each channel. Through the parallel detection mode of the optical fiber array, a high-speed region and low-speed region of bloodflow can be simultaneously given out by utilizing multi-channel detection information, the dynamic range of speed measurement is expanded, and the absolute blood flow speed of the measurement region is obtained. Through the parallel detection mode of the optical fiber array, N times of simultaneous measurements of the same scanning position is achieved, more signal light is obtained, the weightedsummation in data processing is combined to obtain an average value, and a signal-to-noise ratio of microangiography is effectively improved.
Description
technical field [0001] The invention relates to the technical field of optical coherence tomography, in particular to a microangiography method and system based on optical fiber array multi-channel parallel detection. Background technique [0002] Diseases such as glaucoma, macular degeneration and diabetes are closely related to the vascular structure and blood flow of the fundus. However, there are still many defects in the existing conventional angiography techniques, for example, the dye injected by fluorescein angiography can cause nausea and photosensitivity in patients; laser Doppler flowmeter and laser speckle bloodflowmeter cannot provide depth information, It is difficult to distinguish whether the vessels are located in the retina or the choroid. [0003] In recent years, a marker-free optical microangiography technique has been developed based on optical coherence tomography. It has the ability of optical tomography, can obtain high-resolution sample structure i...
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IPC IPC(8): A61B3/10A61B3/12A61B5/00
CPCA61B3/102A61B3/1233A61B5/0066
Inventor 刘勇匡翠方
Owner ZHEJIANG UNIV