Complex compound of cross-linked polyvinylpyrrolidone and iodine and its preparation method and application

A technology for cross-linking polyvinylpyrrolidone and complexes, which is applied in the directions of active ingredients of iodine compounds, active ingredients of artificially synthesized polymeric materials, drug combinations, etc., can solve the problems of poor tissue exudation effect and poor stability, etc.

Active Publication Date: 2021-05-04
SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the complexes of cross-linked polyvinylpyrrolidone and iodine in the prior art have certain improvements in this respect, there are still various defects in controlling the release of the bactericidal substance "free iodine" below the cytotoxic level; in addition, the existing The technical cross-linked polyvinylpyrrolidone and iodine complexes are not effective in absorbing tissue exudate, which is in urgent need of improvement
Moreover, the cross-linked polyvinylpyrrolidone and iodine complexes prepared by the prior art also have the problem of poor stability

Method used

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  • Complex compound of cross-linked polyvinylpyrrolidone and iodine and its preparation method and application
  • Complex compound of cross-linked polyvinylpyrrolidone and iodine and its preparation method and application
  • Complex compound of cross-linked polyvinylpyrrolidone and iodine and its preparation method and application

Examples

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Effect test

Embodiment 1

[0050] Embodiment 1 prepares the complex compound of cross-linked polyvinylpyrrolidone and iodine

[0051] The present embodiment adopts the raw material of formula 1, the preparation method of the complex compound of cross-linked polyvinylpyrrolidone and iodine, comprises the following steps:

[0052] (1) In the reaction vessel with a temperature control device and a stirring device, add the cross-linked polyvinylpyrrolidone PVPP XL-10, refined iodine, alginate and catalyst in sequence, seal the reaction vessel, and stir the materials at normal temperature 60min to mix well, control the stirring speed to 50r / min.

[0053] (2) Set the reaction temperature to 80° C., stir, and control the stirring speed to 200 r / min. After the temperature rises to the temperature setting value, continue the heat preservation reaction for 24 hours.

[0054] (3), stop heating, lower the temperature of the material in the reactor, and discharge the material after the temperature of the material d...

Embodiment 2

[0056] Embodiment 2 prepares the complex compound of cross-linked polyvinylpyrrolidone and iodine

[0057] The present embodiment adopts the raw material of formula 2, the preparation method of the complex compound of cross-linked polyvinylpyrrolidone and iodine, comprises the following steps:

[0058] (1) In a reaction vessel with a temperature control device and a stirring device, add the cross-linked polyvinylpyrrolidone PVPPINF-10, refined iodine, alginate and catalyst in sequence, seal the reaction vessel, and stir the materials at room temperature for 50 minutes To mix evenly, control the stirring speed to 100r / min.

[0059] (2) Set the reaction temperature to 90°C, stir, and control the stirring speed to 300r / min. After the temperature rises to the temperature setting value, continue the heat preservation reaction for 20h.

[0060] (3), stop heating, lower the temperature of the material in the reactor, and discharge the material after the temperature of the material d...

Embodiment 3

[0062] Embodiment 3 prepares the complex compound of cross-linked polyvinylpyrrolidone and iodine

[0063] The present embodiment adopts the raw material of formula 3, the preparation method of the complex compound of cross-linked polyvinylpyrrolidone and iodine, comprises the following steps:

[0064] (1) In a reaction vessel with a temperature control device and a stirring device, sequentially add cross-linked polyvinylpyrrolidone PVPP XL, refined iodine, alginate and a catalyst in the prescribed amount, seal the reaction vessel, and stir the material for more than 40 minutes at normal temperature Mix evenly, and control the stirring speed to 150r / min.

[0065] (2) Set the reaction temperature to 100° C., stir, and control the stirring speed to 400 r / min. After the temperature rises to the temperature setting value, continue the heat preservation reaction for 18 hours.

[0066] (3), stop heating, lower the temperature of the material in the reactor, and discharge the materi...

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Abstract

The invention discloses a complex compound of cross-linked polyvinylpyrrolidone and iodine and its preparation method and application. The raw materials of the complex compound of cross-linked polyvinylpyrrolidone and iodine include the following components in mass percentage: cross-linked polyvinylpyrrolidone : 53~96.5%; refined iodine: 1.2~20%; alginate: 2.2~22%; catalyst: 0.1~5%; described catalyst is selected from sodium bicarbonate, ammonium bicarbonate, sodium carbonate decahydrate, decahydrate At least one of sodium sulfate hydrate crystals, sodium dihydrogen phosphate dodecahydrate, ammonium oxalate monohydrate, citric acid monohydrate and salicylic acid; after the raw materials are mixed evenly, under stirring conditions, at a temperature of 80-120°C , Airtight reaction 4 ~ 24h. The complex compound of cross-linked polyvinylpyrrolidone and iodine of the present invention has controllable release of free iodine at the action site, and is always maintained between the antibacterial activity threshold and cytotoxicity threshold, and can exert a good bactericidal effect and is far lower than Permissible level of cytotoxicity for normal histiocytes, non-irritating and does not delay wound healing.

Description

technical field [0001] The invention belongs to the technical field of disinfection, and relates to a complex compound of crosslinked polyvinylpyrrolidone and iodine, a preparation method and application thereof. Background technique [0002] Iodine has long been recognized as an antimicrobial agent that is very effective against a wide range of microorganisms including Gram-positive and Gram-negative bacteria, mycobacteria, fungi, protozoa and viruses. Iodine is effective over a wide pH range and unlike most other antiseptics, it is not easily inactivated by proteins in wound fluid / serum. Iodine readily penetrates microbial cell walls and is thought to exert its biocidal activity through a number of interactions including: 1) oxidation of sulfhydryl groups in enzymes and proteins; 2) inactivation through iodination of phenolic groups in amino acids and proteins 3) Iodination of basic -NH-groups (as important hydrogen binding sites) in amino acids and nucleotides; 4) Iodina...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/18A61K31/79A61P31/02A61P17/00A61P17/02A61L15/18A61L15/24A61L15/44A61L15/46
CPCA61K31/79A61K33/18A61L15/18A61L15/24A61L15/44A61L15/46A61L2300/202A61L2300/404A61L2300/412A61P17/00A61P17/02A61P31/02C08L39/06
Inventor 王宇熊俊超陈占魏亚娜
Owner SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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