Capsule for improving liver damage and body fatigue and preparation method thereof

A liver injury and capsule technology, which is applied in the field of capsules and its preparation for improving liver injury and body fatigue, can solve the problems of poor taste, difficulty in stabilizing glutathione levels, and high production costs, so as to achieve convenience in taking and improve liver health. Injury and body fatigue, improve the effect of liver damage

Active Publication Date: 2022-05-13
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above method, some cell types may lack the ability to fully uptake liposomal glutathione. No human trials have shown that liposomal glutathione is more effective than conventional glutathione, and its production cost is higher , the taste is poor (viscous oily liquid); because the synthesis of glutathione in vivo not only requires sufficient precursor amino acids, but also depends on many physiological factors and the intracellular environment (such as the activity of the key coenzyme NADPH, suitable pH, etc.) , so the glutathione synthesized in the body is difficult to maintain at a steady-state level, and there is no experimental evidence that supplementing glutathione precursors can help improve liver damage and body fatigue

Method used

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  • Capsule for improving liver damage and body fatigue and preparation method thereof
  • Capsule for improving liver damage and body fatigue and preparation method thereof
  • Capsule for improving liver damage and body fatigue and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] According to 1000 capsules, the dosage of each component of the capsule is: reduced glutathione 300g, turmeric extract 60g, taurine 50g, filler 38g, binder 40g, disintegrant 10g, lubricant 2g. The composition and quality of the turmeric extract are respectively: 70% of turmeric powder, 10% of curcuminoids, and 20% of turmeric water extract. After the turmeric extract is micronized, its particle size ranges from 10 to 100 μm. The composition and quality of each auxiliary material are respectively: filler: microcrystalline cellulose 10g, dextrin 28g, binding agent: PVP-K30 (polyvinylpyrrolidone-K30) 20g, hypromellose 20g, disintegrant: two Silicon oxide 10g, lubricant: magnesium stearate 2g.

[0043] The preparation method of the present embodiment capsule is:

[0044] (1) Mix the reduced glutathione, taurine, turmeric extract and auxiliary materials except the lubricant according to the proportioning ratio, and dry granulate;

[0045] (2) Then add lubricant, fill holl...

Embodiment 2

[0047] Based on 1000 capsules, the dosage of each component of the capsule is: reduced glutathione 200g, turmeric extract 30g, taurine 200g, filler 113g, binder 45g, disintegrant 15g, lubricant 8g. The composition and quality of the turmeric extract are respectively: 20% of turmeric powder, 20% of curcuminoids, and 60% of turmeric water extract. After the turmeric extract is micronized, its particle size ranges from 0.05 to 10 μm. The composition and quality of each auxiliary material are respectively: filler: microcrystalline cellulose 65g, dextrin 48g, binding agent: PVP-K30 (polyvinylpyrrolidone-K30) 15g, hypromellose 30g, disintegrant: two Silicon oxide 15g, lubricant: magnesium stearate 8g.

[0048] The preparation method of the capsule of this embodiment is the same as that of Example 1.

Embodiment 3

[0050] Based on 1000 capsules, the dosage of each component of the capsule is: reduced glutathione 500g, turmeric extract 250g, taurine 30g, filler 170g, binder 60g, disintegrant 26g, lubricant 14g. The composition and quality of the turmeric extract are respectively: 50% of turmeric powder, 15% of curcuminoids, and 35% of turmeric water extract. The composition and quality of each auxiliary material are respectively: filler: microcrystalline cellulose 150g, dextrin 20g, binder: PVP-K30 (polyvinylpyrrolidone-K30) 50g, hypromellose 10g, disintegrant: two Silicon oxide 26g, lubricant: magnesium stearate 14g.

[0051] The preparation method of the capsule of this embodiment is the same as that of Example 1.

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Abstract

The invention relates to a capsule for improving liver damage and body fatigue and a preparation method thereof, belonging to the technical fields of medical technology and health food. The capsule of the present invention comprises the following components in parts by weight: 200-500 parts of reduced glutathione, 30-250 parts of turmeric extract, 30-200 parts of taurine, 38-170 parts of filler, 40 parts of binder ~60 parts, disintegrant 10~26 parts, lubricant 2~14 parts. The capsule of the present invention uses reduced glutathione, turmeric extract, and taurine as main raw materials, can increase the level of glutathione in the body and make it reach a steady state, and effectively improve liver damage and body fatigue; the capsule of the present invention The capsule formula is scientific, convenient to take, and has stable and remarkable efficacy.

Description

technical field [0001] The invention relates to a capsule for improving liver damage and body fatigue and a preparation method thereof, belonging to the technical fields of medical technology and health food. Background technique [0002] Glutathione (GSH) is a tripeptide widely present in biological cells, composed of glutamic acid, cysteine ​​and glycine, and is considered to be the "mother of antioxidants". As an endogenous substance in the cells of the body, the content of glutathione is an important indicator to measure the oxidation-reduction state of cells, and plays an important role in maintaining cell redox homeostasis. It is generally believed that the level of glutathione in the body determines the level of cellular antioxidant and detoxification metabolism. The sulfhydryl group (-SH) in the glutathione molecule can combine with cellular free radicals and oxides to protect cells from oxidative damage and promote Produce high energy and regulate the metabolic pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/06A61K9/48A61K47/42A61K47/46A61P1/16A61P39/00A23L33/18A23L33/105A23L33/175A61K36/9066A61K31/185
CPCA61K36/9066A61K38/06A61K47/42A61K47/46A61P1/16A61P39/00A23L33/105A23L33/175A23L33/18A61K9/4816A61K9/4866A61K31/185A23V2002/00A61K2300/00A23V2250/21A23V2200/30A23V2250/0644A23V2250/31
Inventor 陈红英颜慷祺潘碧妍何国熙黄孟秋卢瑞芯
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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