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A medicine-carrying chitosan/sodium alginate slow-release microparticle algistat and a preparing method thereof

A technology of sodium alginate and slow-release particles, which is applied in botany equipment and methods, herbicides and algicides, bactericidal/microdynamic water/sewage treatment, etc. The effect of inhibiting the outbreak of algae, avoiding secondary pollution, and prolonging the inhibition time is achieved

Inactive Publication Date: 2019-05-21
HOHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, the allelopathy of aquatic plants has been widely concerned; however, the release of allelochemicals from aquatic plants has regional limitations, long allelopathy cycle, and slow effect.
If pure allelochemicals are directly injected, it is easy to be diluted, degraded and lost, and the inhibitory concentration cannot be reached, and secondary pollution is likely to occur in practical applications
[0004] Microcapsule technology has attracted the attention of many scholars in the aspect of ecologically safe algastatic agents, and a variety of slow-release granules for embedding allelopathic active substances have been developed; Water is easy to expand, the particle size is large, and it is easy to sink, which affects the actual water body algae inhibition effect

Method used

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  • A medicine-carrying chitosan/sodium alginate slow-release microparticle algistat and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] S1. Dissolve 0.06g of sodium alginate in 60ml of deionized water to form a 1mg / ml sodium alginate solution, and adjust its pH to 4.7;

[0032] S2. Take 0.02g of carboxylic acid allelopathic active substances and add them to 18ml of 0.6mg / ml CaCl2 solution, stir and mix well, and add dropwise to the sodium alginate solution at a rate of 1ml / min, and place on a magnetic stirrer Stir at a speed of 1000r / min for 30min, and use an ultrasonic breaker to perform ultrasonic treatment for 10min to obtain a pregel solution;

[0033] S3, get 0.012g chitosan and be dissolved in the glacial acetic acid solution of 1% of 20ml, and adjust its pH to be 5.1, then drop in the pregel solution with the drip speed of 1ml / min, again on magnetic stirrer with Stir at a speed of 1000r / min for 60min, and use an ultrasonic breaker to perform ultrasonic treatment for 1min;

[0034] S4. Centrifuge the prepared suspension under the condition of 12000r / min for 30min, wash the slow-release particles ...

Embodiment 2

[0038] S1. Dissolve 0.08g of sodium alginate in 80ml of deionized water to form a 1mg / ml sodium alginate solution, and adjust its pH to 4.7;

[0039] S2. Take 0.03g of carboxylic acid allelopathic active substances and add them to 20ml of 0.6mg / ml CaCl2 solution, stir and mix well, and add dropwise to the sodium alginate solution at a rate of 1ml / min, and place on a magnetic stirrer Stir at a speed of 1100r / min for 30min, and use an ultrasonic breaker to perform ultrasonic treatment for 10min to obtain a pregel solution;

[0040] S3, get 0.015g chitosan and be dissolved in the glacial acetic acid solution of 1% of 25ml, and adjust its pH to be 5.1, then drop in the pregel solution with the drip speed of 1ml / min, again on magnetic stirrer with Stir at a speed of 1000r / min for 60min, and use an ultrasonic breaker to perform ultrasonic treatment for 1min;

[0041] S4. Centrifuge the prepared suspension under the condition of 12000r / min for 30min, wash the slow-release particles ...

Embodiment 3

[0045] S1. Dissolve 0.04g of sodium alginate in 40ml of deionized water to form a 1mg / ml sodium alginate solution, and adjust its pH to 4.7;

[0046] S2. Take 0.01g carboxylic acid allelopathic active substance and add it to 15ml of 0.6mg / ml CaCl2 solution, stir and mix, and dropwise add it into the sodium alginate solution at a rate of 1ml / min, and place it on a magnetic stirrer Stir at a speed of 900r / min for 30min, and use an ultrasonic breaker to perform ultrasonic treatment for 10min to obtain a pregel solution;

[0047] S3, get 0.01g chitosan and be dissolved in the glacial acetic acid solution of 1% of 18ml, and adjust its pH to be 5.1, then drop in the pregel solution with the drop speed of 1ml / min, again on magnetic stirrer with Stir at a speed of 900r / min for 60min, and use an ultrasonic breaker to perform ultrasonic treatment for 1min;

[0048]S4. Centrifuge the prepared suspension under the condition of 12000r / min for 30min, wash the slow-release particles after c...

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Abstract

A medicine-carrying chitosan / sodium alginate slow-release microparticle algistat is disclosed, including slow-release microparticles and a carboxylic acid type active allelochemical embedded in the microparticles. The slow-release microparticles are formed from sodium alginate polyanion and chitosan amino cations through ion crosslinking reaction. Through combination of micro-nano techniques, chitosan and sodium alginate are adopted as carrier materials to embed the carboxylic acid type algae suppression active substance to prepare the slow-release microparticle algistat having a small particle size. The algistat is not liable to expand or sink, can prolong Microcystis aeruginosa suppressing time of the carboxylic acid type active allelochemical in water bodies, can reduce the cost, and can effectively solves a problem that direct addition of the carboxylic acid type active allelochemical into a water body has defects of large active substance dosage, easy loss, incapability of reaching an algae suppression concentration, and the like. The adopted chitosan and the sodium alginate are natural nontoxic biodegradable polymer materials good in biocompatibility, and can effectively avoid secondary pollution in algae suppression processes. The algistat can be widely applied for natural water bodies such as ponds, reservoirs and lakes.

Description

technical field [0001] The invention relates to an algae inhibitor, in particular to a drug-loaded chitosan / sodium alginate slow-release particulate algae inhibitor and a preparation method thereof, belonging to the technical field of water body eutrophication inhibition of algae outbreak. Background technique [0002] There are various ways to control algae blooms at home and abroad. Among them, technologies such as source control and pollution interception, cyanobacteria salvage and interception, algae suppression and algae elimination, and ecological restoration are flexibly adopted, and single or multiple methods are adopted according to the lake area and algae outbreak situation. However, phenomena such as algal blooms and lake flooding still occur in some typical lakes or watersheds, and this has become a key problem to be solved in the field of water resource protection. [0003] In recent years, the allelopathy of aquatic plants has been widely concerned; however, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/28A01N37/40A01N37/04A01N37/36C02F1/50A01P13/02
Inventor 倪利晓顾国秀荣诗怡胡玲玲刘烜瑜王娜王逸飞
Owner HOHAI UNIV
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