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50 results about "Micro nanotechnology" patented technology

Drug-loading micro-needle promoted and controlled by nanogold photo-thermal effect

The invention relates to a drug-loading micro-needle promoted and controlled by a nanogold photo-thermal effect. The drug-loading micro-needle is composed of three components including gold nanoparticles, a photosensitizer wrapped by a lipidosome and a soluble micro-needle substrate material, wherein the mass concentration ratio of the three components in the micro-needle is 1:(1-50):(1-100). By utilizing the nanogold photo-thermal effect, the photo-thermal effect is generated by stimulating nanogold mixed in the micro-needle, so that decomposition of the micro-needle is promoted; therefore, rapid and controllable release of drugs are realized; when nanogold and the drugs enter skin tissue, the skin tissue permeability can be continuously increased through the nanogold photo-thermal effect, so that the drugs can be well delivered into deep tissue. The drug-loading micro-needle disclosed by the invention is a medical application research by combining an optical technology with a micro and nano technology in the field of biomedical engineering; in particular for a micro-needle system loaded with photosensitizer drugs, in the event of monitoring the photosensitization in tissue in real time, individual photodynamic therapy based on individual differences of patients can be realized through control of drug release by nanogold.
Owner:XI AN JIAOTONG UNIV

Atomic force microscope probe based on structures of carbon nano tube and planar wave guide

The invention provides an atomic force microscope probe based on structures of a carbon nano tube and a planar wave guide, belonging to the technical field of micronano. The atomic force microscope probe comprises a probe substrate platform compatible with the atomic force microscope, a planar wave guide attached to the surface of the probe substrate platform and a carbon nano tube as a probe point. when in use, the planar waveguide structure is connected to a high-frequency (microwave) measuring instrument, and the whole probe is arranged to the atomic force microscope (AFM) and is scanned or positioned by the standard operation of the AFM, so that the surface topography of a measuring sample can be measured and the high-frequency characteristics of the measuring sample can be synchronously measured in situ. Particularly, the high-frequency (microwave) transmission with small signal loss can be carried out by using the planar waveguide; the carbon nanotube as the probe point has excellent high-frequency transmission property and the mechanical property; the diameter of the carbon nanotube can be adjusted by controlling growth conditions; in addition, the invention is suitable for high-precision and high-frequency (high-frequency) measurement.
Owner:PEKING UNIV

Laser stimulated emission depletion (STED) and three-dimensional superresolving spectral pupil differential confocal imaging method and device

The invention belongs to the technical field of test of optical precise imaging, and relates to a laser stimulated emission depletion (STED) and three-dimensional superresolving spectral pupil differential confocal imaging method and device. The method and device are characterized in that the spectral pupil laser differential confocal detecting technology and the laser STED imaging technology are organically integrated, the characteristics of high resolution and high scatter suppression of the spectral pupil laser differential confocal detecting technology are integrated, the laser differential confocal technology is performed to improve the axial resolution capacity, the STED technology is performed to improve the transverse resolution capacity, and as a result, the spatial resolution capacity of the system and the resistance to sample scattering can be improved. The device comprises an excitation laser system, a first dichroic mirror, a quarter-wave plate, a measuring objective lens, a sample, a scanning workbench, a quenching laser system, a beam-shaping system, a second dichroic mirror, a spectral pupil differential confocal detecting system and a data processing module. The method and device have an extensive application prospect in the micro-nano technical field with the high spatial resolution and high scattering sample suppression three-dimensional superresolving imaging and detecting capacities.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY

Phospholipid bilayer membrane array fabricated by multilayer polyelectrolyte membrane substrate and fabrication method

InactiveCN103030305AEnrich and expand preparation methodsEasy to operateMultilayer membraneMicro nano
The invention relates to a phospholipid bilayer membrane array fabricated by a multilayer polyelectrolyte membrane substrate and a fabrication method. A static layer-by-layer self-assembly technology is adopted to fabricate polyelectrolyte poly-(4-sodium styrene sulfonate) (PSS) and poly-(diallyl dimethyl ammonia chloride) (PDDA) multilayer membranes on a silicon substrate modified by 3-ammonia propyltriethoxysilane, the modified substrate is subjected to patterning by a photetching technology, arrays of a polyelectrolyte in different types are fabricated, a phospholipid bilayer membrane is fabricated at the bottoms of the arrays, and the phospholipid bilayer membrane array is fabricated. According to the method, the layer-by-layer assembly technology is introduced into the fabrication of the patterned substrate, the fabrication method of the phospholipid bilayer membrane array is enriched and expanded, the method has the advantages of simplicity in operation, mild reaction conditions, good controllability, high stability, low cost and the like, and a reliable technology is provided for the research and application of biological membrane characteristics with respect to the fields of membrane biophysics, interface chemistry, biochemistry, bionics and micro-nano technologies.
Owner:HARBIN INST OF TECH

Method for rapidly corroding and patterning indium tin oxide surface by using electrochemical technology

The invention relates to a method for rapidly corroding and patterning an indium tin oxide (ITO) surface by using an electrochemical technology, belonging to the fields of electrochemistry and micro-nanotechnologies. Aiming at the problem of the traditional ITO-corroding method, the method for rapidly corroding and patterning the indium tin oxide surface by using the electrochemical technology, provided by the invention, comprises the steps as follows: (1) washing the ITO surface; (2) pressing a used photoresist into a protective film on an ITO substrate by using a plastic-envelop machine, directly placing a mask of a used pattern, performing ultraviolet exposure and developing, and forming and washing to form a needed pattern; (3) corroding exposed ITO part of the photoresist on the ITO surface with diluted hydrochloric acid as a corrosive liquid by using cyclic voltammetry or chronoamperometry and the electrochemical technology; and (4) washing an electrochemically corroded ITO glass sheet by using an alkali solution, removing a protective photoresist film; and drying by using N2 to obtain a patterned ITO surface. The method for rapidly corroding and patterning the indium tin oxide surface by using the electrochemical technology has the advantages of simplicity in operation, high speed, good corrosive effect, clearness of borders, low cost and the like.
Owner:HARBIN INST OF TECH

A medicine-carrying chitosan/sodium alginate slow-release microparticle algistat and a preparing method thereof

A medicine-carrying chitosan / sodium alginate slow-release microparticle algistat is disclosed, including slow-release microparticles and a carboxylic acid type active allelochemical embedded in the microparticles. The slow-release microparticles are formed from sodium alginate polyanion and chitosan amino cations through ion crosslinking reaction. Through combination of micro-nano techniques, chitosan and sodium alginate are adopted as carrier materials to embed the carboxylic acid type algae suppression active substance to prepare the slow-release microparticle algistat having a small particle size. The algistat is not liable to expand or sink, can prolong Microcystis aeruginosa suppressing time of the carboxylic acid type active allelochemical in water bodies, can reduce the cost, and can effectively solves a problem that direct addition of the carboxylic acid type active allelochemical into a water body has defects of large active substance dosage, easy loss, incapability of reaching an algae suppression concentration, and the like. The adopted chitosan and the sodium alginate are natural nontoxic biodegradable polymer materials good in biocompatibility, and can effectively avoid secondary pollution in algae suppression processes. The algistat can be widely applied for natural water bodies such as ponds, reservoirs and lakes.
Owner:HOHAI UNIV

A medicine-carrying chitosan slow-release microparticle algistat and a preparing method thereof

A medicine-carrying chitosan slow-release microparticle algistat and a preparing method thereof are disclosed. The algistat includes slow-release microparticles and a carboxylic acid type active allelochemical embedded in the microparticles. The slow-release microparticles are formed from chitosan amino cations and sodium tripolyphosphate polyanion through ion crosslinking reaction. Through combination of micro-nano techniques, chitosan and sodium tripolyphosphate are adopted as carrier materials to embed the carboxylic acid type algae suppression active substance to prepare the slow-release microparticle algistat which has a small particle size and which is not liable to expand or sink. The Microcystis aeruginosa suppressing time of the carboxylic acid type active allelochemical in waterbodies is prolonged, the cost is reduced, and a problem that direct addition of the carboxylic acid type active allelochemical into a water body has defects of large active substance dosage, easy loss, incapability of reaching an algae suppression concentration, and the like can be effectively solved. The adopted chitosan and the sodium tripolyphosphate are natural nontoxic biodegradable polymer materials good in biocompatibility, and can effectively avoid secondary pollution in algae suppression processes. The algistat can be widely applied for natural water bodies such as ponds, reservoirs and lakes.
Owner:HOHAI UNIV

A light-driven vibration motor device based on optical fiber

The invention belongs to the research field of the optical fiber micro-nanotechnology, in particular to an optical-driven vibration motor device capable of stably changing the position and the vibration frequency of absorbent particles. The device comprises an optical tweezers system consisting of a first optical fiber light source, a second optical fiber light source, an optical fiber wavelengthdivision multiplexer and a single-mode optical fiber, and the optical tweezers system, an absorbent black sphere and liquid form the optical-driven vibration motor device. Two kinds of photophoretic forces are used to play an optical driving role on the absorbent particles, the absorbent black sphere can be stably captured in a non-contact mode, and the position and the vibration frequency of theabsorbent black sphere driven by the optical-driven vibration motor can be controlled. The position and the vibration frequency of absorbent particles can be changed and driven at the same time through changing the power of two light sources; the position of the device is accurately controlled and the structure is simple; the absorbent particles in the liquid background can be easily optically driven; and the adopted device is low in price, the making method is simple, and the device is suitable for being promoted in the field of biomedicine.
Owner:HARBIN ENG UNIV

Optical fiber-based optical-driven vibration motor device

The invention belongs to the research field of the optical fiber micro-nanotechnology, in particular to an optical-driven vibration motor device capable of stably changing the position and the vibration frequency of absorbent particles. The device comprises an optical tweezers system consisting of a first optical fiber light source, a second optical fiber light source, an optical fiber wavelengthdivision multiplexer and a single-mode optical fiber, and the optical tweezers system, an absorbent black sphere and liquid form the optical-driven vibration motor device. Two kinds of photophoretic forces are used to play an optical driving role on the absorbent particles, the absorbent black sphere can be stably captured in a non-contact mode, and the position and the vibration frequency of theabsorbent black sphere driven by the optical-driven vibration motor can be controlled. The position and the vibration frequency of absorbent particles can be changed and driven at the same time through changing the power of two light sources; the position of the device is accurately controlled and the structure is simple; the absorbent particles in the liquid background can be easily optically driven; and the adopted device is low in price, the making method is simple, and the device is suitable for being promoted in the field of biomedicine.
Owner:HARBIN ENG UNIV

Application of ultra-micro nanotechnology in preparation technology of edible fungus crisps

The invention discloses an application of ultra-micro nanotechnology in a preparation technology of edible fungus crisps. The preparation technology of the edible fungus crisps comprises the following steps: S1, crushing accessory ingredients to be dipped together with the edible fungi under impact of air flows by using an ultrafine airflow grinder so as to prepare ultrafine powder of which the granule size is 10-12 microns, and cooling the ultrafine powder until temperature of the ultrafine powder is 6 DEG C below zero to 0 DEG C; S2, crushing the cooled ultrafine powder into powder of which the granule size is 100 nanometers or smaller by using a nanometer-grinder so as to prepare nanometer-grade accessory ingredients; and S3, adding the edible fungi and the nanometer-grade accessory ingredients into a vacuum dipping device according to a mass ratio of 1: (0.8-1.2), pumping air from the vacuum dipping device so as to maintain a pre-set vacuum degree, so that the edible fungi are immersed by the nanometer-grade accessory ingredients. The coating method disclosed by the preparation technology makes the edible fungi high in absorption rates to the accessory ingredients, so that the edible fungi are fully flavored; moreover, yields of the edible fungi after dipping are greatly improved.
Owner:东莞爱尚菇食品科技有限公司

Elastic film variable-capacitance type platelet micro-force sensor based on micro-nano technology

PendingCN107036738ARapid Quantitative Assessment of Comprehensive FunctionalityQuantitative rapid measurementForce measurementDiagnostic recording/measuringCapacitancePlatelet contraction
The invention relates to an elastic film variable-capacitance type platelet micro-force sensor based on micro-nano technology. The platelet micro-force sensor is a parallel-board variable capacitor and comprises an upper anode board and a lower cathode board, wherein the upper anode board and the lower cathode board are parallel with each other. The outer side surface of the anode board is provided with a barrel-shaped anode gold film and an anode leading-out measuring contact. An anode working surface is provided with an organic silicon intermediate material layer. The inner bottom surface of the barrel-shaped anode metal film is provided with a human fibronectin layer. The cathode working surface of the cathode board is provided with a cathode gold film and a cathode leading-out measuring contact. The sensor provided by the invention can perform quick, simple and direct measurement on a platelet contraction force. The elastic film variable-capacitance type platelet micro-force sensor is necessary technical equipment which performs functions of settling a worldwide problem of testing middle-and-later period function of the platelet, researching the physiological mechanism and pathological mechanism of the platelet, finding out abnormal platelet function in an early period, guiding development of a platelet anticoagulant medicaments and illuminating a forming mechanism of related diseases.
Owner:黄昱
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