Elastic film variable-capacitance type platelet micro-force sensor based on micro-nano technology

Abstract

The invention relates to an elastic film variable-capacitance type platelet micro-force sensor based on micro-nano technology. The platelet micro-force sensor is a parallel-board variable capacitor and comprises an upper anode board and a lower cathode board, wherein the upper anode board and the lower cathode board are parallel with each other. The outer side surface of the anode board is provided with a barrel-shaped anode gold film and an anode leading-out measuring contact. An anode working surface is provided with an organic silicon intermediate material layer. The inner bottom surface of the barrel-shaped anode metal film is provided with a human fibronectin layer. The cathode working surface of the cathode board is provided with a cathode gold film and a cathode leading-out measuring contact. The sensor provided by the invention can perform quick, simple and direct measurement on a platelet contraction force. The elastic film variable-capacitance type platelet micro-force sensor is necessary technical equipment which performs functions of settling a worldwide problem of testing middle-and-later period function of the platelet, researching the physiological mechanism and pathological mechanism of the platelet, finding out abnormal platelet function in an early period, guiding development of a platelet anticoagulant medicaments and illuminating a forming mechanism of related diseases.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to a novel micro-nano real-time monitoring sensor for rapid qualitative detection of platelet comprehensive function. Background technique [0002] As the smallest cell in the human body, platelets not only play a vital role in normal physiological hemostasis, but also play a key role in pathological thrombosis and atherosclerosis. Such as Figure 6 As shown, the schematic diagram of platelet activation after skin damage, in which: (a) when the endothelial cell layer on the blood vessel wall is not damaged, the platelet is in an inactive state; (b) when the endothelial cell layer is damaged, the platelet is rapidly activated Activated to adhere to the extracellular matrix of the damaged site; (c) activated platelets will change their shape to increase the surface area and cover the damaged vessel wall; (d) activated platelets will secrete procoagulant factors , to activate mo...

AI Technical Summary

Problems solved by technology

However, the functional detection and research of platelets in the world still mainly rely on the measurement of some early indicators of platelets in the process of hemostatic response and the viscoelastic characteristics of hemostatic plugs (such as LTA, VerifyNow P2Y12 Assay, Plateletworks, Impact-R, PFA 100 platelet function analyzer, etc.), lack of assessment of platelet function in the later stage, which limits its application in scientific research and clinical diagnosis, and it is difficult to provide conclusive conclusions on the comprehensive function of platelets

Moreover, the measurement of platelet contractility at this stage relies on a closed large-scale detection system, which has low measurement accuracy and cannot observe the mechanical interaction phenomenon of platelets at the dynamic subcellular scale in real time.

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