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Entire-column preparation method of nano-particle stabled Pickering emulsion based packing

A nanoparticle and monolithic column technology, applied in the fields of analysis and detection and micro-nano, can solve the problems of different hydrophilicity and hydrophobicity, and cannot separate and enrich molecules with different hydrophilicity and hydrophobicity at the same time, so as to achieve rich preparation methods, good biocompatibility, The effect of widening the variety

Active Publication Date: 2017-06-13
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that the fillers of the existing monolithic columns have different hydrophilicity and hydrophobicity, and cannot simultaneously separate and enrich molecules with different hydrophilicity and hydrophobicity, and provide a method for preparing monolithic columns based on nanoparticle-stabilized Pickering emulsions as fillers

Method used

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  • Entire-column preparation method of nano-particle stabled Pickering emulsion based packing
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  • Entire-column preparation method of nano-particle stabled Pickering emulsion based packing

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specific Embodiment approach 1

[0035] Embodiment 1: This embodiment is a method for preparing a monolithic column based on nanoparticle-stabilized Pickering emulsion as a filler. The method is specifically completed according to the following steps:

[0036] 1. Preparation of nanoparticles stabilized Pickering emulsion:

[0037] Mix the nanomaterials with the oil phase, then ultrasonically disperse for 10 to 60 minutes, add the water phase, and then vortex and mix for 1 to 10 minutes to obtain a nanoparticle-stabilized Pickering emulsion;

[0038] The oil phase described in step 1 is a mixture of solvent and silane, and the volume ratio of silane to solvent in the mixture of solvent and silane is (5 μL-30 μL): 1 mL;

[0039] The water phase described in step 1 is a mixed solution of distilled water and polyelectrolyte; the volume ratio of polyelectrolyte to distilled water in the water phase is (2μL-8μL): 1mL;

[0040] The volume ratio of the mass of the nanomaterial described in step 1 to the oil phase is...

specific Embodiment approach 2

[0059] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the power of the ultrasonic dispersion described in Step 1 is 30W-80W. Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0060] Embodiment 3: The difference between this embodiment and Embodiment 1 or Embodiment 2 is that the rotation speed of the vortex mixing described in step 1 is 500r / min-3000r / min. Other steps are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses an entire-column preparation method of a nano-particle stabled Pickering emulsion based packing and relates to the technical field of analytical detection and micro-nano, in particular to a preparation method of an entire column with an aim to mainly solve problems that existing packings of the entire column are different in hydrophilic-hydrophobic properties and cannot be separated from molecules different in enrichment hydrophilicities. The method includes: 1), preparing a nano-particle stabled Pickering emulsion; 2), pretreating the entire column; 3), filling the Pickering in the entire column; 4), eluting the entire column to obtain the entire column of the nano-particle stabled Pickering emulsion based packing. The method has the advantages of rapidness, high efficiency, convenience, low cost and environment friendliness, and meanwhile, the packing can be prepared in large quantities and reused; the entire-column preparation method of the nano-particle stabled Pickering emulsion based packing can be acquired.

Description

technical field [0001] The invention relates to the fields of analysis and detection and micro-nano technology, in particular to a method for preparing a monolithic column. Background technique [0002] As a separation and enrichment packed column, the monolithic column is a new type of chromatographic column that has developed very rapidly in recent years. It has the advantages of high separation efficiency, good biocompatibility, good permeability, simple preparation technology, etc., and is widely used. On analytical instruments such as high performance liquid chromatography, micronanoliter high performance liquid chromatography, and capillary electrochromatography. At present, the prepared monolithic columns can be divided into two categories according to the properties of their synthetic materials: organic polymer filling and inorganic material filling. The preparation method is relatively simple, and the two types of monolithic columns have their own advantages and di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/283B01J20/30B01D15/22
CPCB01D15/22B01J20/283
Inventor 佟珊珊王林李晓舟罗锐
Owner NORTHWEST A & F UNIV
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