Drug-loading micro-needle promoted and controlled by nanogold photo-thermal effect

Abstract

The invention relates to a drug-loading micro-needle promoted and controlled by a nanogold photo-thermal effect. The drug-loading micro-needle is composed of three components including gold nanoparticles, a photosensitizer wrapped by a lipidosome and a soluble micro-needle substrate material, wherein the mass concentration ratio of the three components in the micro-needle is 1:(1-50):(1-100). By utilizing the nanogold photo-thermal effect, the photo-thermal effect is generated by stimulating nanogold mixed in the micro-needle, so that decomposition of the micro-needle is promoted; therefore, rapid and controllable release of drugs are realized; when nanogold and the drugs enter skin tissue, the skin tissue permeability can be continuously increased through the nanogold photo-thermal effect, so that the drugs can be well delivered into deep tissue. The drug-loading micro-needle disclosed by the invention is a medical application research by combining an optical technology with a micro and nano technology in the field of biomedical engineering; in particular for a micro-needle system loaded with photosensitizer drugs, in the event of monitoring the photosensitization in tissue in real time, individual photodynamic therapy based on individual differences of patients can be realized through control of drug release by nanogold.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a drug-loaded microneedle controlled by the photothermal effect of nano-gold, which can promote and control the decomposition and release of the drug-containing polymer microneedle by using the photothermal effect of nano-gold, while increasing epidermal circulation. Permeability increases drug transdermal absorption. Background technique [0002] Transdermal drug delivery through microneedles is a new drug injection technology developed in recent years that is painless, minimally invasive, less prone to infection and has a definite curative effect. Since Henry et al published in 1998 the use of micro-channels produced by micro-needles for transdermal drug delivery, micro-needle technology has been greatly developed. From the most primitive preparation of metal microneedles to the later development of silicon-based microneedles, polymer microneedles and degradable...

AI Technical Summary

Problems solved by technology

Although this patent can use the partition to press liquid medicine into the microneedle tube to achieve controllability, the equipment is complicated and the cost of microneedle preparation is high

Moreover, microneedle tubes are prone to deformation when piercing the skin, which will cause pore blockage and cannot exert a controllable effect.

Some published literature abroad in recent years, such as: Yan, L. et al. "Nan ocomposite-strengthened dissolving microneedles for improved transde rmal delivery to human skin." Advanced healthcare materials, 2014, 3(4):pp.555– 64 Although the mechanical strength of soluble microneedles has been enhanced by adding nanoparticles, it is still impossible to achieve controlled release of drugs

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