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Surface-modified metal bone implant material and preparation method and application thereof

A technology for surface modification and implantation of materials, applied in the field of medical devices, can solve problems such as poor antibacterial performance, achieve the effect of improving antibacterial performance and reducing the chance of infection

Inactive Publication Date: 2019-05-24
BEIJING AKEC MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to provide a surface-modified metal bone implant material, its preparation method and application, so as to solve the problem of poor antibacterial properties of metal bone implant materials in the prior art and easily lead to infection complications

Method used

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  • Surface-modified metal bone implant material and preparation method and application thereof
  • Surface-modified metal bone implant material and preparation method and application thereof
  • Surface-modified metal bone implant material and preparation method and application thereof

Examples

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preparation example Construction

[0037] According to another aspect of the present invention, there is also provided a method for preparing a surface-modified metal bone implant material, which includes the following steps: S1, preparing a porous metal bone implant substrate; S2, using atomic layer deposition, The porous metal bone implant substrate is placed in the deposition chamber, the zinc-containing compound and the oxygen source are passed into the deposition chamber, and the zinc-containing organic matter and the oxygen source are reacted and deposited on the surface of the porous metal bone implant substrate to form an oxide A zinc deposition layer, thereby forming a surface-modified metal bone implant material; wherein the zinc-containing compound is a zinc-containing organic compound and / or a zinc-containing halide.

[0038] Using the method provided by the invention, a zinc oxide deposition layer is deposited on the surface of the porous metal bone implant substrate. The zinc oxide deposition laye...

Embodiment 1

[0052] In this example, a surface-modified metal bone implant material was prepared, and the specific preparation process was as follows:

[0053] 1) Preparation of porous metal bone implant base material: The porous metal bone implant base material was prepared by electron beam melting technology, the metal material was Ti-6Al-4V, the porous structure was an amorphous full microporous structure, and the porosity was 90% , the pore size is 300-500 μm.

[0054] 2) Dissolve calcium acetate and sodium dihydrogen phosphate in deionized water, mix the reagents evenly, and prepare an electrolyte solution, in which the concentration of calcium acetate is 0.01mol / L, the concentration of sodium dihydrogen phosphate is 0.035mol / L, and EDTA- The concentration of 2Na is 0.02mol / L, Na 2 SiO 3 The concentration of the solution is 0.04mol / L, add an appropriate amount of KOH, and adjust the pH value of the solution to 11; use an AC power supply to supply power for the micro-arc oxidation, c...

Embodiment 2

[0057] The difference with Example 1 is:

[0058] The porous structure of the porous metal bone implant substrate is an amorphous full microporous structure with a porosity of 40% and a pore diameter of 600-900 μm.

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Abstract

The invention provides a surface-modified metal bone implant material and a preparation method and application thereof. The surface-modified metal bone implant material comprises a porous metal bone implant base and a zinc oxide deposit layer; the zinc oxide deposit layer is positioned on the surface of the porous metal bone implant base; the zinc oxide deposit layer can significantly inhibit andeliminate Escherichia coli, staphylococcus and the like; antibacterial performance of the metal bone implant material is greatly improved; the zinc oxide deposit layer is significant to reducing the infection rate of metal bone implant materials.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a surface-modified metal bone implant material, its preparation method and application. Background technique [0002] Due to bone and joint injuries, bone tumors and bone defects caused by various reasons, it is very difficult to perform joint replacement or joint reconstruction. These bone and joint parts often form an irregular defect area, and the traditional metal implanted joints need to be filled with autologous bone from the patient, causing harm to the patient. At the same time, it is difficult to manufacture a prosthesis that conforms to the anatomical structure by using traditional manufacturing methods, and because the elastic modulus of traditional solid titanium alloy is quite different from that of human bone, stress is prone to occur even after implantation Shielding, resulting in secondary fractures. [0003] Porous titanium alloy materials prepared by fiber sinte...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/30A61L27/50A61L27/32A61L27/06A61L27/54C23C28/04C23C16/40C23C16/455C25D7/00C25D11/02C25D11/26
Inventor 魏崇斌李新宇陈博周梦王彩梅李志疆
Owner BEIJING AKEC MEDICAL
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