Application for preparing medicine for treating dry eye and method for treating dry eye

A dry eye disease and drug technology, applied in the field of dry eye disease, can solve problems such as low bioavailability, and achieve the effect of inhibiting dry eye and inhibiting ROS imbalance

Active Publication Date: 2019-05-31
WENZHOU MEDICAL UNIV
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the structural properties of the eyeball, traditional o

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application for preparing medicine for treating dry eye and method for treating dry eye
  • Application for preparing medicine for treating dry eye and method for treating dry eye
  • Application for preparing medicine for treating dry eye and method for treating dry eye

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] Combine now figure 1 , figure 2 , image 3 , Figure 4 The present invention is further described,

[0015] 1) Dry eye model

[0016] 72 healthy C57BL / 6 mice aged 4-6 weeks, female, without ocular surface infection and inflammation, without old leukoplakia, and with a corneal fluorescein sodium staining score of less than 10 (provided by the Experimental Animal Center of Wenzhou Medical University, after Approved by the Experimental Animal Ethics Committee of Wenzhou Medical University.). 64 mice were raised in an intelligent environment control system (relative humidity 15±3%, wind speed 2.1±0.2 m / s, temperature 21-23 ℃) as experimental groups for different interventions (6 mice in each group treated for 3 days, 1-week treatment group (2 mice in each group); 8 mice were raised in a normal environment without any treatment as the normal control group (NC). In the breeding environment, the light is irradiated from the ceiling above to the ground below, and the ill...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Provided are application for preparing a medicine for treating dry eye and a method for treating dry eye. By targeting intraocular oxygen free radical (ROS) inhibitors to mitochondria, by improving the efficiency of translocation of exogenous antioxidants across cell membranes, and by enriching the oxygen free radical (ROS) inhibitors in the mitochondria, or around the mitochondria, a mitochondrial ROS eliminated in situ, thereby inhibiting ROS imbalance from the source and blocking a signaling pathway that generates ocular inflammation, which ultimately inhibits ROS imbalance and suppresses the occurrence of dry eye from the source.

Description

technical field [0001] The invention specifically relates to the technical field of dry eye syndrome, in particular to an application for preparing a medicine for dry eye syndrome and a method for treating dry eye syndrome. Background technique [0002] Dry eye is a clinically common eye disease, also known as keratoconjunctival sicca. Epidemiological studies have shown that with the aging of the society, the increase in the use of video terminals, the increasingly serious environmental pollution, and the increase in the incidence of diabetes, the number of dry eye cases worldwide is rising sharply. Among the middle-aged and elderly people aged 50 and above in the world, the incidence of dry eye is about 5.5%-33.7%. Dry eye clinically manifests as dry eyes, easy fatigue, itchy eyes, foreign body sensation, burning sensation, sticky secretions, Fear of wind, photophobia, sensitivity to external stimuli, etc.; severe cases can lead to redness and swelling of the eyes, hyperem...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K45/00A61K31/728A61K31/662A61P27/02
Inventor 陈蔚郑钦象李玲林森葛超翔
Owner WENZHOU MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap