A pretreatment method for direct mass spectrometry detection of n-pentane in exhaled air
A technology of n-pentane and exhaled gas, which is applied in the field of online mass spectrometry analysis of exhaled gas, can solve problems such as interference, and achieve the effects of strong applicability, realization of removal, and simple device
Active Publication Date: 2021-06-01
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology
However, there are still interferences from other oxygenates at mass number 71, such as C 4 h 7 O, the exact mass is 71.050, may be the characteristic peak of crotonaldehyde
Method used
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Effect test
specific Embodiment example 1
[0025] The sampling bag is directly connected to the sample inlet of the mass spectrometer, that is, no pretreatment is performed on the exhaled gas sample, and no signal peak of n-pentane is detected in the spectrum of the collected exhaled gas sample.
specific Embodiment example 2
[0027] The sampling bag was connected to the sample inlet of the mass spectrometer after passing through the Nafion online dehumidification system, that is, only the exhaled gas sample was dehumidified, and no signal peak of n-pentane was detected in the spectrum of the collected exhaled gas sample.
specific Embodiment example 3
[0029] The sampling bag is connected to the sample inlet of the mass spectrometer after the Nafion online dehumidification system and DNPH silica gel column, that is, the exhaled gas sample is dehumidified and carbonyl compound removed, and n-pentane can be detected in the collected exhaled gas sample spectrum signal peak.
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The invention discloses a pretreatment method for direct mass spectrometry detection of n-pentane in exhaled air. In this method, the online Nafion dehumidification system and 2,4-dinitrophenylhydrazine silica gel column (DNPH) are used together to pretreat the exhaled breath samples in the sampling bag for the direct mass spectrometry detection of n-pentane in the exhaled breath. The online Nafion dehumidification system includes a Nafion tube, a casing for the circulation of the purge gas and the purge gas; one end of the Nafion tube is connected to the outlet of the sampling bag, the other end is connected to the DNPH silica gel column, and the other end of the DNPH silica gel column is connected to the mass spectrometer connected to the injection port of the instrument. The exhaled gas sample in the sampling bag passes through the Nafion tube and the DNPH silica gel column in turn, that is, after being dehydrated and decarbonylated respectively, it enters the mass spectrometer for analysis and detection.
Description
technical field [0001] The invention belongs to the field of online mass spectrometry analysis of exhaled gas, and relates to a pretreatment method for direct mass spectrometry detection of n-pentane in exhaled gas. The method avoids the interference of humidity and carbonyl-containing compounds on the detection of n-pentane by removing the humidity and carbonyl-containing compounds of the exhaled breath sample, and realizes the accurate detection of n-pentane by direct mass spectrometry. Background technique [0002] Some products of human metabolism can be transported by the blood to the lungs, enter the alveoli through gas exchange, and appear in the exhaled air. The research results show that small molecular metabolites in exhaled breath are related to the metabolism and pathology of the body, and some substances may even become biomarkers of certain diseases, such as ketones are related to diabetes, and S-containing compounds such as dimethyl sulfide reflect liver func...
Claims
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IPC IPC(8): G01N27/62G01N1/28G01N1/34
Inventor 李海洋王艳花磊侯可勇李庆运
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI