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Rabdosia serra stem and leaf wall-breaking decoction pieces for treating acute icteric hepatitis, acute cholecystitis and dysentery and preparation method of rabdosia serra stem and leaf wall-breaking decoction pieces

A technology for acute cholecystitis and acute jaundice, which is used in medical preparations containing active ingredients, pharmaceutical formulations, and resistance to vector-borne diseases. , Conducive to the development of modern large-scale industrialization and the effect of stable quality

Inactive Publication Date: 2019-06-07
JIANGXI GROUNDIONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the broken-wall decoction piece technology is not widely used in domestic decoction piece production enterprises, and no real industry norms have been formed.
Therefore, research and development of a preparation method of broken Chinese medicine decoction pieces, give full play to the advantages of using the whole ingredients of Chinese medicine broken wall decoction pieces, retain all the medicinal ingredients of traditional Chinese medicine by breaking the wall, which is more conducive to the absorption of medicinal ingredients by users , in order to alleviate the problem that the existing traditional Chinese medicine granules can only extract part of the medicinal ingredients after adding water to concentrate, it becomes very necessary and urgent
Yet, also do not have the report about Xi Huangcao broken wall decoction pieces and preparation technology thereof at present

Method used

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Examples

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preparation example Construction

[0017] The preparation method of the broken wall decoction pieces of Xihuangcao of the present invention comprises the following steps:

[0018] (a) Pre-crushing the dried Xihuang herbal medicinal material to obtain granules with a particle size of 10-100 mesh;

[0019] (b) soaking the particles with the first ethanol aqueous solution, the concentration of the first ethanol aqueous solution is 30-60% by weight;

[0020] (c) filter, and freeze-dry the obtained filter cake,

[0021] (d) Place at a temperature of -10°C to 0°C for 1-3 hours;

[0022] (e) Microwave-treating the obtained Xihuangcao particles under vacuum conditions, followed by ultrafine pulverization, to obtain ultrafine powders below 40 microns;

[0023] (f) mixing the ultrafine powder with a second ethanol aqueous solution, and then performing granulation and drying, the concentration of the second ethanol aqueous solution being 60-80% by weight.

[0024] In the method of the present invention, after the pre-g...

Embodiment 1

[0038] (1) Take 2.0kg of Xihuangcao medicinal material, pre-crushed to a particle size of 50 mesh, then add 4 times the volume of Xihuangcao granules in 45% by weight ethanol solution, soak at 70°C for 2 hours, and use 200 mesh stainless steel wire Filter through a mesh, and freeze-dry the obtained filter cake at -20°C under a vacuum of 30 Pa. After the Xihuangcao granules were dried, they were placed at -5°C for 2 hours.

[0039] (2) Place the Sihuangcao granules obtained in step (1) under vacuum conditions and carry out microwave treatment. The conditions of microwave treatment are: temperature is 25°C, time is 30min, microwave power is 15kW, and vacuum degree is 15Pa.

[0040] (3) Carry out superfine pulverization to the sagegrass granules obtained in step (2) with a CW5-100QA wall-breaking superfine pulverizer to obtain ultrafine powder with a particle size of 5-30 microns.

[0041] (4) The ultrafine powder is mixed with ethanol aqueous solution with a concentration of 70...

Embodiment 2

[0043] (1) Take 2.0kg of Xihuangcao medicinal material, pre-crushed to a particle size of 80 mesh particles, then add 3 times the volume of Xihuangcao granules in 60% by weight ethanol solution, soak for 3 hours at 50 ° C, and use a 200-mesh stainless steel wire The obtained filter cake was lyophilized at -30° C. under a vacuum of 20 Pa. After the Xihuangcao granules were dried, they were placed at -8°C for 1 hour.

[0044](2) Place the Sihuangcao granules obtained in step (1) under vacuum conditions and carry out microwave treatment. The conditions of microwave treatment are: temperature is 20°C, time is 40min, microwave power is 10kW, and vacuum degree is 10Pa.

[0045] (3) Carry out superfine pulverization to the sagegrass granules obtained in step (2) with a CW5-100QA wall-breaking superfine pulverizer to obtain ultrafine powder with a particle size of 5-30 microns.

[0046] (4) Mix the ultrafine powder with 60% by weight ethanol aqueous solution at a weight ratio of 1:0....

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Abstract

The invention relates to the technical field of traditional Chinese medicine wall-breaking decoction pieces, and discloses rabdosia serra stem and leaf wall-breaking decoction pieces for treating acute icteric hepatitis, acute cholecystitis and dysentery and a preparation method of the rabdosia serra stem and leaf wall-breaking decoction pieces. The method comprises the following steps of (a) pre-crushing dry rabdosia serra stem and leaf medicinal materials; (b) soaking granular substances in first ethanol water; (c) performing filtration, and performing freeze drying on filter cakes; (d) performing placing at the temperature of minus 10-0 DEG C for 1-3 hours; (e) performing microwave treatment on obtained rabdosia serra stem and leaf granules under the vacuum condition, and then performing superfine crushing; and (f) mixing obtained superfine fine powder with second ethanol water, and then performing granulation and drying. Through the adoption of the method disclosed by the invention, the rabdosia serra stem and leaf wall-breaking decoction pieces higher in wall-breaking rate can be prepared.

Description

technical field [0001] The invention relates to the technical field of broken-wall decoction pieces of traditional Chinese medicine, in particular to Xihuangcao broken-wall decoction pieces for treating acute jaundice hepatitis, acute cholecystitis and dysentery and a preparation method thereof. Background technique [0002] Broken-wall decoction pieces of traditional Chinese medicine is a traditional Chinese medicine decoction piece processed in powder form by using modern ultrafine pulverization technology. Broken wall decoction pieces of traditional Chinese medicine are all ingredients used as medicine, and the medicinal material basis remains unchanged, which is in line with the connotation of Chinese medicine decoction pieces. It can be directly brewed and taken together with the dregs of the medicine. However, the broken-wall decoction pieces technology is not widely used in domestic decoction pieces production enterprises, and no real industry norms have been formed....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K36/53A61P1/16A61P1/12
CPCY02A50/30
Inventor 廖年生邹明明肖云
Owner JIANGXI GROUNDIONG PHARM CO LTD
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