The invention discloses a zinc oxide piezoresistor with a safety protection device. The piezoresistor comprises a piezoresistor main body, an epoxy resin wrapping layer, a protective cover, a clampingblock, a pole piece, a heat dissipation cover, a convex block, a heat dissipation plate, a first connecting rod, an arc-shaped block, a fixed block, a connecting pipe, a connecting plate, a protective pipe, connecting pieces, a connecting groove, a screw pipe, a second connecting rod, a fixed ring, a connecting column, a heat conduction rod, a bonding pad, limiting grooves and limiting strips. According to the invention, the connecting groove is formed, so the connecting pieces are conveniently broken, so that the length of the connecting pieces is conveniently adjusted according to differentmounting positions, the mounting efficiency is improved, meanwhile, the heat conduction rod, the heat dissipation plate and the heat dissipation cover are used for conducting heat dissipation treatment on the device, the epoxy resin wrapping layer is wrapped by the mounted heat dissipation cover and protective cover, therefore, the piezoresistor main body, the pole piece, the bonding pad, the connecting column and the heat conducting rod are protected, and the device is protected.