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Dynamic real-time evaluation device and evaluation method for irreversible electroporation tissue ablation effect

A technology for tissue ablation and evaluation equipment, applied in the direction of heating surgical instruments, etc., can solve the problem that tumors are difficult to achieve real-time dynamic monitoring of curative effect during treatment, and achieve the effect of avoiding signal instability and reflecting the limited ablation area

Active Publication Date: 2019-06-14
CHONGQING UNIV
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Problems solved by technology

[0007] The purpose of the present invention is to provide a dynamic and real-time evaluation device and evaluation method for irreversible electroporation tissue ablation effect, so as to solve the problem that it is difficult to realize real-time dynamic monitoring of curative effect during treatment and immediate evaluation of curative effect after treatment in the current irreversible electroporation treatment of tumors

Method used

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  • Dynamic real-time evaluation device and evaluation method for irreversible electroporation tissue ablation effect
  • Dynamic real-time evaluation device and evaluation method for irreversible electroporation tissue ablation effect
  • Dynamic real-time evaluation device and evaluation method for irreversible electroporation tissue ablation effect

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Embodiment Construction

[0068] Such as figure 1 A dynamic and real-time evaluation device for the tissue ablation effect of irreversible electroporation is shown, including a test pulse action unit, an output switching unit, a signal acquisition unit, a data processing unit, a user interface and a power supply for powering the device.

[0069] Each unit is described in detail below:

[0070] The test pulse action unit includes a test pulse generation unit, a control unit, and an electrode array; the test pulse generation unit is used to generate a test pulse signal, and is used to obtain the biological tissue by applying the test pulse signal before and after high-voltage pulse processing. Electrical properties of tissue in its initial state, during high-pulse treatment, and after treatment. Wherein, the pulse width of the test pulse signal is at least reaching the pulse width capable of stabilizing the response current, and its specific range may vary depending on the pulse width depending on the t...

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Abstract

The invention discloses a dynamic real-time evaluation device and evaluation method for an irreversible electroporation tissue ablation effect. Electrodes participating and not participating pulse transfer in a primary pulse application process of irreversible electroporation tumor treatment are utilized to detect the tissue impedance spectrum change before and after pulse treatment and effectively avoid unstable measurement of an impedance spectrum signal of a pulse application electrode and limited reflection of the ablation area. According to the impedance spectrum change measured by different electrodes, the relationship between the impedance spectrum change and the actual ablation size is built after subsequent data processing. At the same time, a small signal testing pulse application mode is adopted to acquire the tissue electric performance change during treatment and build a mathematical model to achieve the judgment of the tissue ablation situation. Advantages of a sweep frequency mode and a testing pulse mode are combined to achieve the effect that the treatment effect is dynamically monitored in the treatment process and assessed immediately after treatment of the ablation effect after irreversible electroporation pulse treatment.

Description

technical field [0001] The invention relates to a dynamic and real-time evaluation device and evaluation method for irreversible electroporation tissue ablation effect. Background technique [0002] Cancer is a major disease that endangers human health. The traditional therapy of tumors and the newly developed thermal ablation physical therapy characterized by minimally invasive ablation have certain limitations in their clinical application due to the limitations of indications, contraindications, side effects of treatment, and heat depression. In recent years, with the continuous development of pulsed bioelectricity, electric field pulses have attracted the attention of researchers for their non-thermal and minimally invasive biomedical effects, and the irreversible electroporation treatment of tumors is fast, controllable, visible, and The advantages and characteristics of selectivity and non-thermal mechanism have attracted widespread attention of researchers in the fie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/12
CPCA61B18/12
Inventor 姚陈果董守龙赵亚军刘红梅马剑豪廖瑞金
Owner CHONGQING UNIV
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