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Antioxidant and preparation method thereof

An antioxidant and esterification technology, which is applied in the field of antioxidants and their preparation, can solve the problems of high extraction cost, low antioxidant activity, and impurities of natural antioxidants, and achieve the effects of no toxic side effects, low price, and stable properties

Inactive Publication Date: 2019-06-14
WUHAN POLYTECHNIC UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction cost of natural antioxidants is high and there will inevitably be impurities, resulting in low purity, and because they mostly function as active ingredients in the form of monomers, they are not only easy to be metabolized, but also have low antioxidant activity.

Method used

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  • Antioxidant and preparation method thereof

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preparation example Construction

[0036] In addition, in order to solve the above problems, the present invention also proposes a preparation method of an antioxidant, combining figure 1 A schematic flow diagram of an embodiment of the preparation method of the antioxidant shown, the preparation method of the antioxidant comprises the following steps:

[0037] Step S10, adding chlorosulfonic acid dropwise into anhydrous pyridine to react to form an esterification reagent.

[0038] When step S10 is implemented, in an embodiment of the present invention, step S10 may include:

[0039] Cool the reaction vessel containing anhydrous pyridine in an ice-salt bath;

[0040] Under an ice-salt bath, slowly add chlorosulfonic acid dropwise into the reaction vessel while stirring, and react to form an esterification reagent.

[0041] Wherein, the volume ratio of the chlorosulfonic acid to anhydrous pyridine is 1:(3-5); the temperature during the reaction is 0-4°C, and the reaction time is 0.5-2h.

[0042] When pyridine...

Embodiment 1

[0060] Place the anhydrous pyridine cooled in the refrigerator in advance in a three-necked flask with a condenser and a stirring device, and cool it in an ice-salt bath; under vigorous stirring, the volume ratio of chlorosulfonic acid to anhydrous pyridine is 1:4 (20ml:80ml) Slowly add chlorosulfonic acid dropwise, continue cooling in an ice-salt bath, control the reaction temperature at 4°C, and obtain a pale yellow esterification reagent after 1 hour of reaction.

[0061] Accurately weigh 500 mg of rice bran polysaccharide and suspend it in 35 ml of N,N-dimethylformamide (DMF), add 100 ml of the prepared above-mentioned esterification reagent, and stir and react at 70° C. for 2 h.

[0062] After the reaction is finished, neutralize with 4mol / L NaOH solution to titrate to a pH value of 6.8. Add 95% ethanol to the neutralized neutral solution to form a mixed solution until the mass fraction of ethanol in the mixed solution is 70%. The mixed solution was centrifuged to collec...

Embodiment 2

[0065] Place the anhydrous pyridine cooled in the refrigerator in advance in a three-necked flask with a condenser and a stirring device, and cool it in an ice-salt bath; under vigorous stirring, the volume ratio of chlorosulfonic acid to anhydrous pyridine is 1:3 (20ml:60ml) Slowly add chlorosulfonic acid dropwise, continue cooling in an ice-salt bath, control the reaction temperature at 2°C, and obtain a light yellow esterification reagent after 0.5h of reaction.

[0066] Accurately weigh 350 mg of rice bran polysaccharide and suspend it in 35 ml of N,N-dimethylformamide (DMF), add 50 ml of the above prepared esterification reagent, and stir and react at 60° C. for 1.5 h.

[0067] After the reaction is finished, titrate and neutralize with 1mol / L NaOH solution to a pH value of 7.2. Add 95% ethanol to the neutralized neutral solution to form a mixed solution until the mass fraction of ethanol in the mixed solution is 70%. The mixed solution was centrifuged to collect the pre...

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Abstract

The invention discloses an antioxidant and a preparation method thereof and relates to the technical field of antioxidants. The antioxidant comprises esterified rice bran polysaccharide. The preparation method of the antioxidant comprises the following steps: Dropwise adding chlorosulfonic acid into anhydrous pyridine and reacting to form an esterification reagent; adding rice bran polysaccharideinto N,N-dimethylformamide and stirring to form a suspension system; adding the esterification reagent into the suspension system and stirring to form a reaction solution; after adjusting the reactionsolution to be neutral, adding 95 percent ethanol into the reaction solution; carrying out solid-liquid separation to obtain sediment; after dissolving the sediment in water, dialyzing; collecting retention liquid and concentrating in vacuum; and after drying, obtaining the esterified rice bran polysaccharide. The property of the antioxidant prepared by the method is more stable than that of ricebran polysaccharide and the antioxidant has a strong anti-oxidization function, is easily absorbed by organisms and has no toxic or side effect on the organisms.

Description

technical field [0001] The invention relates to the technical field of antioxidants, in particular to an antioxidant and a preparation method thereof. Background technique [0002] There is a paradox in the metabolism of organisms. Although most organisms on earth need oxygen to survive, oxygen is a highly reactive molecule that can produce reactive oxygen species. When active oxygen in the body is produced Too much, the body's antioxidant capacity is reduced, or the mechanism of production and clearance is out of balance, it will accumulate in the body and cause oxidative damage to cells. Reactive oxygen species generated intracellularly include hydrogen peroxide, hypochlorous acid, free radicals such as hydroxyl radicals, and superoxide anion. Among them, hydroxyl radicals are particularly unstable and can react with most biomolecules non-specifically and quickly, or oxidize DNA and proteins to damage cells. [0003] Antioxidant is any substance that can effectively inhi...

Claims

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Application Information

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IPC IPC(8): C08B37/00
Inventor 刘梁燕宇剑吴淑恒潘显虎熊学敏
Owner WUHAN POLYTECHNIC UNIVERSITY
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