The New Application of Polyacetylenic Compounds in Lowering Uric Acid

A compound and uric acid-lowering technology, which can be applied to active ingredients of hydroxyl compounds, medical preparations containing active ingredients, drug combinations, etc., can solve undisclosed problems

Active Publication Date: 2021-08-24
CATCH BIO SCI & TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned literature does not disclose the specific active ingredients that play the role of reducing uric acid in the Kunlun snow chrysanthemum extract

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • The New Application of Polyacetylenic Compounds in Lowering Uric Acid
  • The New Application of Polyacetylenic Compounds in Lowering Uric Acid
  • The New Application of Polyacetylenic Compounds in Lowering Uric Acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Grind 30 kg of dried Codonopsis pilosula root, soak and extract at room temperature with 5 times the weight of 95% ethanol aqueous solution for 3 times, extract for one week each time, combine the extracts, distill and concentrate under reduced pressure until there is no alcohol smell, to obtain extract. The extract was dispersed in 1 volume of distilled water, and then extracted with ethyl acetate and n-butanol respectively to obtain 212 g of ethyl acetate extraction parts and 178 g of n-butanol extraction parts.

[0045] The ethyl acetate extraction part was separated by silica gel column chromatography (100-200 mesh), using dichloromethane-methanol as the eluent (volume ratio 50:1-50:30) for gradient elution, and the results were determined by TLC. Combined to obtain a total of five eluates from Fr.1.1 to Fr.1.5. The Fr.1.2 eluate was separated again by silica gel column chromatography, using dichloromethane-methanol as the eluent (volume ratio of 20:1-20:15) for gra...

Embodiment 2

[0055] 30 kg of dried Codonopsis cordifolioidea was soaked and extracted 3 times at room temperature with 95% ethanol solution with a volume concentration of 5 times the weight, and each time was extracted for 1 week. , get extract. The extract was dispersed in 1 volume of distilled water and extracted with n-butanol to obtain 151 g of n-butanol extraction fractions. The n-butanol extraction part is separated by AB-8 macroporous resin, and the gradient elution is carried out according to the following procedures: water, methanol aqueous solution with a volume concentration of 35%, methanol aqueous solution with a volume concentration of 75%, and methanol, and the mobile phases are collected separately The eluate was concentrated under reduced pressure to obtain 36 g of the elution fraction of methanol as the mobile phase. The elution site of methanol as mobile phase is separated by silica gel column chromatography (100-200 mesh), and the mixed solvent of dichloromethane-metha...

Embodiment 3

[0058] Get 100 kg of snow chrysanthemum medicinal material, soak and extract with 15 times the volume of ethanol aqueous solution with a volume concentration of 70% after pulverization, concentrate under reduced pressure to remove the organic solvent, extract the concentrated solution 3 times with 1 times the amount of ethyl acetate, combine the ethyl acetate layers, reduce Concentrate under reduced pressure to remove the organic solvent to obtain the ethyl acetate extraction fraction. The ethyl acetate extraction part was separated by ODS reversed-phase silica gel column chromatography, and the mixed solvent of methanol-water was used for gradient elution at 1mL / min according to the following procedure: the volume fraction of methanol was 10%, 30%, 45%, 60% %, 80%, 90%, and 100%, respectively, 6 eluates Fr.A-G were obtained.

[0059]Among them, Fr.B was separated by silica gel column chromatography, and the mixed solvent of ethyl acetate-ethanol was used as the mobile phase t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of medicines or health care products, and in particular relates to the new application of polyacetylenic compounds in reducing uric acid. The polyalkyne compound has a structure shown in formula (I): R 1 , R 2 , R 3 and R 4 As shown in the definition of the description of the present invention. The research of the present invention finds that the polyalkyne compound isolated from snow chrysanthemum and Codonopsis pilosula has uric acid-lowering activity and has no obvious toxic and side effects, and can be used to treat hyperuricemia and gout or gout complications caused by hyperuricemia.

Description

technical field [0001] The invention belongs to the field of medicines or health care products, and in particular relates to the new application of polyacetylenic compounds in reducing uric acid. Background technique [0002] Uric acid is the final metabolite of human purine compounds, and purine metabolism disorders lead to hyperuricemia. Under a normal purine diet, if the blood uric acid level on an empty stomach is higher than 416 μmol / L for men and 360 μmol / L for women on two different days, it is called hyperuricemia. Gout is a crystal-associated arthropathy caused by the deposition of monosodium urate (MSU), which is directly related to hyperuricemia caused by purine metabolic disorders and / or decreased uric acid excretion. The main clinical manifestation is hyperuricemia , recurrent gouty acute arthritis, gouty chronic arthritis and tophi, gouty nephropathy and renal uric acid stones, etc. In severe cases, joint disability and renal insufficiency may occur. In addit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7032A61K31/7048A61K31/351A61K31/047A61P19/06
Inventor 温尧林
Owner CATCH BIO SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap