Method for establishing compound model of severe cerebral hemorrhage complicated with sepsis of rat and application of method

Abstract

The invention relates to a method for establishing a compound model of severe cerebral hemorrhage complicated with sepsis of a rat. The method comprises the steps that after the rat is anesthetized byinjection, tail amputation is carried out, the blood is taken and injected into the caudate nucleus at the right side at a constant speed, and a cerebral hemorrhage rat model is obtained; after the cerebral hemorrhage rat model is successfully prepared, a cecal ligation and puncture method is adopted to obtain the compound model of the severe cerebral hemorrhage complicated with the sepsis of therat. The invention further relates to application of the compound model in the preparation of a drug for preventing/treating the severe cerebral hemorrhage complicated with the sepsis. According to the method for establishing the compound model of the severe cerebral hemorrhage complicated with the sepsis of the rat and the application of the compound model in the preparation of the drug for preventing/treating the severe cerebral hemorrhage complicated with the sepsis, the compound model of the severe cerebral hemorrhage complicated with the sepsis is successfully constructed to better simulate the clinical manifestations of the clinical severe cerebral hemorrhage complicated infection and sepsis and provide a theoretical basis for further exploring pathogenesis and intervening measuresof the severe cerebral hemorrhage complicated infection and sepsis; the compound model is applied to screening of the drug for treating the severe cerebral hemorrhage and sepsis and is of great significance for the prevention and treatment of the severe cerebral hemorrhage complicated infection and sepsis, later rehabilitation and prognosis.

Description

technical field [0001] The invention relates to the field of medical animal models, in particular to a method for establishing a compound model of severe cerebral hemorrhage in rats complicated with sepsis and its application. Background technique [0002] Cerebral hemorrhage accounts for about 15% of all strokes in European and American countries. The incidence rate of Asian population is higher than that of European and American countries. The incidence rate of ICH in my country is as high as 18.47%. Hemorrhagic morbidity was higher and mortality from sepsis due to concurrent infection was higher. Nosocomial infection is the most common complication in patients with severe cerebral hemorrhage, and its incidence rate is about 80%. Sepsis and multiple organ failure caused by infection are one of the main causes of death in severe cerebral hemorrhage. [0003] Patients with severe cerebral hemorrhage are particularly prone to nosocomial infection and progress to sepsis due to...

AI Technical Summary

Problems solved by technology

At present, the treatment measures for cerebral hemorrhage and sepsis are separate and independent, and they are aimed at certain pathophysiological changes during the development of the disease. Part of the neuroendocrine immune response network, making treatment l

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