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Application of cycloastragenol in preparation of medicine for treating psoriasis

A technology of cycloastragenol and psoriasis, which is applied in the field of application of cycloastragenol in the preparation of drugs for treating psoriasis, can solve the problems of little research and achieve the effect of improving related symptoms and reducing skin thickening

Active Publication Date: 2021-06-15
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Since the chemical structure of Cycloastragenol (CAG) was reported, there have been few studies on this compound, and there have been no reports about its pharmacological activity, especially the effect of treating diseases related to psoriasis.

Method used

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  • Application of cycloastragenol in preparation of medicine for treating psoriasis
  • Application of cycloastragenol in preparation of medicine for treating psoriasis
  • Application of cycloastragenol in preparation of medicine for treating psoriasis

Examples

Experimental program
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Effect test

Embodiment 1

[0027] 1. Pharmacological experiment of cycloastragenol

[0028] Imiquimod-induced mouse psoriasis model [1]

[0029] C57BL / 6 female mice, aged 6-8 weeks, weighing 18-22 grams, were raised in an SPF animal room at 21±2°C, free to drink and eat, and alternate day and night for 12 hours. After the mouse was anesthetized with 1% pentobarbital sodium, the hair on the back of the mouse was shaved in an area of ​​about 2 cm×2 cm to expose the back skin. Two days later, mice were randomly divided into 6 groups, normal group (Sham group), model group (Imiquimod, IMQ group), cycloastragenol (Cycloastragenol, CAG) low, medium and high dose groups (12.5mg / kg, 25mg / kg, 50mg / kg), andrographolide group (Andrographolide, Andro group, 10mg / kg). The normal group and the model group were given the same amount of PBS, and the other groups were intragastrically administered according to the dosage, once a day, 0.1ml each time. Except for the normal group, the other groups evenly applied imiq...

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Abstract

The invention relates to a new application of cycloastragenol, in particular to the application of cycloastragenol in the preparation of medicines for treating psoriasis. Cycloastragenol can effectively improve skin thickening and infiltration of inflammatory factors in lesioned skin. For imiquimod-induced psoriasis model mice, cycloastragenol can significantly improve the skin thickening of the lesion, and at the same time reduce the level of inflammatory factors infiltrated in the skin of the lesion in a dose-dependent manner.

Description

technical field [0001] The present invention relates to the new use of cycloastragenol, in particular to the application of cycloastragenol in the preparation of medicines for treating psoriasis Background technique [0002] Since the chemical structure of Cycloastragenol (CAG) was reported, there has been little research on this compound, and there has been no report on its pharmacological activity, especially the effect on treating diseases related to psoriasis. The present invention mainly finds that cycloastragenol has a significant improvement effect on psoriasis models. [0003] Cycloastragenol (Cycloastragenol, CAG), its structural formula is as follows: [0004] Contents of the invention [0005] The role of cycloastragenol in the preparation of drugs for the treatment of psoriasis. [0006] Specifically: [0007] 1. Pharmacological experiment of cycloastragenol [0008] Imiquimod-induced mouse psoriasis model [1] [0009] C57BL / 6 female mice, aged 6-8 wee...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P17/06
Inventor 孙洋徐强顾正兵邓国亮朱雨雨
Owner NANJING UNIV